Effects of acute tryptophan depletion on neuropsychological and motor function in Parkinson's disease

Journal of Psychopharmacology

Volumn 24, Issue 10, 2010, Pages 1465-1472

  MacE, J L ^a,b   Porter, R J ^a   Dalrymple Alford, J C ^b,c   Wesnes, K A ^d   Anderson, T J ^a,b,c  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b Van der Veer Institute   (New Zealand)

^c UNIVERSITY OF CANTERBURY   (New Zealand)

^d CDR House ^*  (United Kingdom)

Author keywords

acute tryptophan depletion; cognition; memory; motor symptoms; movement; Parkinson's disease; serotonin

Indexed keywords

DECARBOXYLASE INHIBITOR; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA; MONOAMINE OXIDASE B INHIBITOR; PLACEBO; SEROTONIN; TRYPTOPHAN;

ACUTE TRYPTOPHAN DEPLETION; ADULT; AGE; AGED; ARTICLE; CHOLINERGIC ACTIVITY; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; DIET RESTRICTION; DOPAMINERGIC ACTIVITY; FEMALE; GENDER; HUMAN; INTELLIGENCE QUOTIENT; LATENT PERIOD; MALE; MINI MENTAL STATE EXAMINATION; MOTOR PERFORMANCE; PARKINSON DISEASE; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; SEROTONIN RELEASE; VERBAL BEHAVIOR; VISION; WORD RECOGNITION;

AGED; AGED, 80 AND OVER; COGNITION; CROSS-OVER STUDIES; DEFICIENCY DISEASES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MEMORY, SHORT-TERM; MIDDLE AGED; MOVEMENT DISORDERS; NEUROPSYCHOLOGICAL TESTS; PARKINSON DISEASE; PSYCHOMOTOR PERFORMANCE; REACTION TIME; SEROTONIN; SEVERITY OF ILLNESS INDEX; TRYPTOPHAN;

EID: 77958011927     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881109105721     Document Type: Article

References (39)

1. Aarsland, D., Mosimann, UP, McKeith, IG (2004) Role of cholinesterase inhibitors in Parkinson's disease and dementia with Lewy bodies. J Geriatr Psychiatry Neurol 17: 164-171. (Pubitemid 39128226)
2. Benton, AL, Hamsher, K. (1976) Multilingual Aphasia Examination. Iowa City: University of Iowa.
3. Bohnen, NI, Kaufer, DI, Hendrickson, R., Constantine, GM, Mathis, CA, Moore, RY (2007) Cortical cholinergic denervation is associated with depressive symptoms in Parkinson's disease and parkinsonian dementia. J Neurol Neurosurg Psychiatry 78: 641-643.
4. Bohnen, NI, Kaufer, DI, Hendrickson, R., Ivanco, LS, Lopresti, BJ, Constantine, GM, et al. (2006) Cognitive correlates of cortical cholinergic denervation in Parkinson's disease and parkinsonian dementia. J Neurol 253: 242-247.
5. Bohnen, NI, Kaufer, DI, Ivanco, LS, Lopresti, B., Koeppe, RA, Davis, JG, et al. (2003) Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study. Arch Neurol 60: 1745-1748.
6. Dauer, W., Przedborski, S. (2003) Parkinson's disease: mechanisms and models. Neuron 39: 889-909.
7. Doder, M., Rabiner, EA, Turjanski, N., Lees, AJ, Brooks, DJ (2003) Tremor in Parkinson's disease and serotonergic dysfunction: an 11C-WAY 100635 PET study. Neurology 60: 601-605.
8. Ellenbogen, MA, Young, SN, Dean, P., Palmour, RM, Benkelfat, C. (1996) Mood response to acute tryptophan depletion in healthy volunteers: sex differences and temporal stability. Neuropsychopharmacology 15: 465-474.
9. Fahn, S., Elton, R., Members of the UPDRS Development Committee (1987) Unified Parkinson's Disease Rating Scale. In: Fahn, S, Marsden, CD, Calne, D, Goldstein, M (eds). Recent Developments in Parkinson's Disease 2. Florham Park, NJ: Macmillan Healthcare Information, pp. 153-163.
10. Folstein, M., Folstein, S., McHugh, P. (1975) " Mini mental state" a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189-198.
11. Golightly, KL, Lloyd, JA, Hobson, JE, Gallagher, P., Mercer, G., Young, AH (2001) Acute tryptophan depletion in schizophrenia. Psychol Med 31: 75-84.
12. Harder, JA, Kelly, ME, Cheng, CH, Costall, B. (1996 a) Combined pCPA and muscarinic antagonist treatment produces a deficit in rat water maze acquisition. Pharmacol Biochem Behav 55: 61-65.
13. Harder, JA, Maclean, CJ, Alder, JT, Francis, PT, Ridley, RM (1996 b) The 5-HT1A antagonist, WAY 100635, ameliorates the cognitive impairment induced by fornix transection in the marmoset. Psychopharmacology (Berl) 127: 245-254.
14. Harder, JA, Ridley, RM (2000) The 5-HT1A antagonist, WAY 100 635, alleviates cognitive impairments induced by dizocilpine (MK-801) in monkeys. Neuropharmacology 39: 547-552.
15. Hughes, AJ, Daniel, SE, Kilford, L., Lees, AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinicopathological study of 100 cases. J Neurol Neurosurg Psychiatry 55: 181-184.
16. Leentjens, AF, Scholtissen, B., Vreeling, FW, Verhey, FR (2006) The serotonergic hypothesis for depression in Parkinson's disease: an experimental approach. Neuropsychopharmacology 31: 1009-1015.
17. Mace, JL, Porter, RJ, Dalrymple-Alford, JC, Anderson, TJ The effects of acute tryptophan depletion on mood in patients with Parkinson's disease and the healthy elderly. J Psychopharmacol (Oxford) (in press).
18. Meeter, M., Talamini, L., Schmitt, JA, Riedel, WJ (2006) Effects of 5-HT on memory and the hippocampus: model and data. Neuropsychopharmacology 31: 712-720.
19. Nelson, HE (1982) National Adult Reading Test Manual. Windsor, Berks: NFER-Nelson.
20. Porter, RJ, Lunn, BS, OBrien, J. (2003) Effects of acute tryptophan depletion on cognitive function in Alzheimer's disease and in the healthy elderly. Psychol Med 33: 41-49.
21. Porter, RJ, Lunn, BS, Walker, LL, Gray, JM, Ballard, CG, OBrien, JT (2000) Cognitive deficit induced by acute tryptophan depletion in patients with Alzheimer's disease. Am J Psychiatry 157: 638-640.
22. Porter, RJ, Phipps, AJ, Gallagher, P., Scott, A., Stevenson, PS, OBrien, JT (2005) Effects of acute tryptophan depletion on mood and cognitive function in older recovered depressed subjects. Am J Geriatr Psychiatry 13: 607-615.
23. Reilly, JG, McTavish, SFB, Young, AH (1997) Rapid depletion of plasma tryptophan: a review of studies and experimental methodology. J Psychopharmacol (Oxford) 11: 381-392.
24. Riedel, WJ (2004) Cognitive changes after acute tryptophan depletion: what can they tell us. Psychol Med 34: 3-8.
25. Rinne, JO, Portin, R., Ruottinen, H., Nurmi, E., Bergman, J., Haaparanta, M., et al. (2000) Cognitive impairment and the brain dopaminergic system in Parkinson disease: [18F]fluorodopa positron emission tomographic study. Arch Neurol 57: 470-475.
26. Robbins, TW, James, M., Owen, AM, Sahakian, BJ, McInnes, L., Rabbitt, P. (1994) Cambridge Neuropsychological Test Automated Battery (CANTAB). a factor analytic study of a large sample of normal elderly volunteers. Dementia 5: 266-281.
27. Sambeth, A., Blokland, A., Harmer, CJ, Kilkens, TOC, Nathan, PJ, Porter, RJ, et al. (2007) Sex differences in the effect of acute tryptophan depletion on declarative episodic memory: a pooled analysis of nine studies. Neurosci Biobehav Rev 31: 516-529.
28. Schechter, LE, Dawson, LA, Harder, JA (2002) The potential utility of 5-HT1A receptor antagonists in the treatment of cognitive dysfunction associated with Alzheimer's disease. Curr Pharm Des 8: 139-145.
29. Schillevoort, I., van Puijenbroek, EP, de Boer, A., Roos, RA, Jansen, PA, Leufkens, HG (2002) Extrapyramidal syndromes associated with selective serotonin reuptake inhibitors: a case-control study using spontaneous reports. Int Clin Psychopharmacol 17: 75-79.
30. Scholtissen, B., Verhey, FR, Adam, JJ, Prickaerts, J., Leentjens, AF (2006) Effects of acute tryptophan depletion on cognition, memory and motor performance in Parkinson's disease. J Neurol Sci 248: 259-265.
31. Simpson, PM, Surmon, DJ, Wesnes, KA, Wilcock, GK (1991) The cognitive drug research computerized assessment system for demented patients: a validation study. Int J Geriatr Psychiatry 6: 95-102.
32. Stark, CE, Squire, LR (2001) Simple and associative recognition memory in the hippocampal region. Learn Mem 8: 190-197.
33. Teng, EL, Chui, HC (1987) The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry 48: 314-318.
34. Tiraboschi, P., Hansen, LA, Thal, LJ, Corey-Bloom, J. (2000) Cholinergic dysfunction in diseases with Lewy bodies. Arch Neurol 57: 347-351.
35. Warrington, EK, James, M. (1991) A new test of object decision: 2D silhouettes featuring a minimal view. Cortex 27: 370-383.
36. Werheid, K., Hoppe, C., Thone, A., Muller, U., Mungersdorf, M., von Cramon, DY (2002) The Adaptive Digit Ordering Test: clinical application, reliability, and validity of a verbal working memory test. Arch Clin Neuropsychol 17: 547-565.
37. Weschler, D. (1981) Wechsler Adult Intelligence Scale - Revised. New York: The Psychological Corporation.
38. Yasuno, F., Suhara, T., Nakayama, T., Ichimiya, T., Okubo, Y., Takano, A., et al. (2003) Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory. Am J Psychiatry 160: 334-340.
39. Young, SN, Smith, SE, Pihl, RO, Ervin, FR (1985) Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology (Berl) 87: 173-177.