The endothelin axis stimulates the expression of pro-inflammatory cytokines and pro-migratory molecules in breast cancer

Cancer Investigation

Volumn 28, Issue 9, 2010, Pages 932-943

  Jewell, Ashley N ^a   Swamydas, Muthulekha ^a   Castillo, Claudia I ^a   Wyan, Heather ^a   Allen, Lauren D ^a   McDermott, Kerri A ^a   Eddy, Jill M ^a   Dréau, Didier ^a  

^a UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

Author keywords

Bone; Chemokines; Cytokine; Endothelin 1; ETAR; ETBR; Immunocompetent; Inflammation; Metastasis; Migration

Indexed keywords

BOSENTAN; CCL1 CHEMOKINE; CHEMOTACTIC FACTOR; CUTANEOUS T CELL ATTRACTING CHEMOKINE; CXCL1 CHEMOKINE; CXCL16 CHEMOKINE; CXCL2 CHEMOKINE; CYTOKINE; ENDOTHELIN 1; EOTAXIN 2; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 5; PADGEM PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER INHIBITION; CANCER MODEL; CARCINOMA CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKINFOLD; TREATMENT OUTCOME;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BONE NEOPLASMS; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CYTOKINES; ENDOTHELIN-1; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; INFLAMMATION MEDIATORS; INTERLEUKIN-17; INTERLEUKIN-1ALPHA; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEUTROPHILS; RECEPTORS, ENDOTHELIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SULFONAMIDES; TUMOR BURDEN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77958011212     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.3109/07357907.2010.496757     Document Type: Article

References (61)

1. Traina, T. A.; Rugo, H. S.; Dickler, M. Bevacizumab for advanced breast cancer. Hematol Oncol Clin North Am 2007, 21(2), 303-319.
2. DeNardo, D. G.; Coussens, L. M. Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression. Breast Cancer Res 2007, 9(4), 212.
3. Mantovani, A.; Marchesi, F.; Porta, C.; Sica, A.; Allavena, P. Inflammation and cancer: breast cancer as a prototype. Breast 2007, 16 (Suppl 2), S27-S33.
4. Benoy, I. H.; Salgado, R.; Van Dam, P.; Geboers, K.; Van Marck, E.; Scharpe, S.; Vermeulen, P. B.; Dirix, L. Y. Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival. Clin Cancer Res 2004, 10(21), 7157-7162.
5. Il'yasova, D.; Colbert, L. H.; Harris, T. B.; Newman, A. B.; Bauer, D. C.; Satterfield, S.; Kritchevsky, S. B. Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort. Cancer Epidemiol Biomarkers Prev 2005, 14(10), 2413-2418.
6. Angelo, L. S.; Kurzrock, R. Vascular endothelial growth factor and its relationship to inflammatory mediators. Clin Cancer Res 2007, 13(10), 2825-2830.
7. Radisky, E. S.; Radisky, D. C. Stromal induction of breast cancer: inflammation and invasion. Rev Endocr Metab Disord 2007, 8(3), 279-287.
8. Guise, T. A.; Mohammad, K. S. Endothelins in bone cancer metastases. Cancer Treat Res 2004, 118, 197-212.
9. Knowles, J.; Loizidou, M.; Taylor, I. Endothelin-1 and angiogenesis in cancer. Curr Vasc Pharmacol 2005, 3(4), 309-314.
10. Grimshaw, M. J. Endothelins and hypoxia-inducible factor in cancer. Endocr Relat Cancer 2007, 14(2), 233-244.
11. Herrmann, E.; Bogemann, M.; Bierer, S.; Eltze, E.; Hertle, L.; Wulfing, C. The endothelin axis in urologic tumors: mechanisms of tumor biology and therapeutic implications. Expert Rev Anticancer Ther 2006, 6(1), 73-81.
12. Bagnato, A.; Spinella, F.; Rosano, L. The endothelin axis in cancer: the promise and the challenges of molecularly targeted therapy. Can J Physiol Pharmacol 2008, 86(8), 473-484.
13. Lalich, M.; McNeel, D. G.; Wilding, G.; Liu, G. Endothelin receptor antagonists in cancer therapy. Cancer Invest 2007, 25(8), 785-794.
14. Bagnato, A.; Catt, K. J. Endothelins as autocrine regulators of tumor cell growth. Trends Endocrinol Metab 1998, 9(9), 378-383.
15. Wulfing, P.; Diallo, R.; Kersting, C.; Wulfing, C.; Poremba, C.; Greb, R. R.; Bocker, W.; Kiesel, L. Endothelin-1, endothelin-A-and endothelin-B-receptor expression in preinvasive and invasive breast disease. Oncol Rep 2004, 11(4), 791-796.
16. Kojima, K.; Nihei, Z. Expression of endothelin-1 immunoreactivity in breast cancer. Surg Oncol 1995, 4(6), 309-315.
17. Kaur, B.; Khwaja, F. W.; Severson, E. A.; Matheny, S. L.; Brat, D. J.; Van Meir, E. G. Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis. Neuro-oncol 2005, 7(2), 134-153.
18. Sampaio, A. L.; Rae, G. A.; Henriques, M. G. Effects of endothelin ETA receptor antagonism on granulocyte and lymphocyte accumulation in LPS-induced inflammation. J Leukoc Biol 2004, 76(1), 210-216.
19. Grimshaw, M. J.; Hagemann, T.; Ayhan, A.; Gillett, C. E.; Binder, C.; Balkwill, F. R. A role for endothelin-2 and its receptors in breast tumor cell invasion. Cancer Res 2004, 64(7), 2461-2468.
20. Grimshaw, M. J.; Wilson, J. L.; Balkwill, F. R. Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. Eur J Immunol 2002, 32(9), 2393-2400.
21. Smollich, M.; Gotte, M.; Kersting, C.; Fischgrabe, J.; Kiesel, L.; Wulfing, P. Selective et (A) R antagonist atrasentan inhibits hypoxia-induced breast cancer cell invasion. Breast Cancer Res Treat 2008, 108(2), 175-182.
22. Wulfing, P.; Gotte, M.; Sonntag, B.; Kersting, C.; Schmidt, H.; Wulfing, C.; Buerger, H.; Greb, R.; Bocker, W.; Kiesel, L. Overexpression of endothelin-A-receptor in breast cancer: regulation by estradiol and cobalt-chloride induced hypoxia. Int J Oncol 2005, 26(4), 951-960.
23. Grimshaw, M. J. Endothelins in breast tumour cell invasion. Cancer Lett 2005, 222(2), 129-138.
24. Wilson, J. L.; Burchell, J.; Grimshaw, M. J. Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1. Cancer Res 2006, 66(24), 11802-11807.
25. Dréau, D.; Karaa, A.; Culberson, C.; Wyan, H.; McKillop, I. H.; Clemens, M. G. Bosentan inhibits tumor vascularization and bone metastasis in an immunocompetent skin-fold chamber model of breast carcinoma cell metastasis. Clin Exp Metastasis 2006, 23, 41-53.
26. Yin, J. J.; Mohammad, K. S.; Kakonen, S. M.; Harris, S.; Wu-Wong, J. R.; Wessale, J. L.; Padley, R. J.; Garrett, I. R.; Chirgwin, J. M.; Guise, T. A. A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases. Proc Natl Acad Sci USA 2003, 100(19), 10954-10959.
27. Wulfing, P.; Tio, J.; Kersting, C.; Sonntag, B.; Buerger, H.; Wulfing, C.; Euler, U.; Boecker, W.; Tulusan, A. H.; Kiesel, L. Expression of endothelin-A-receptor predicts unfavourable response to neoadjuvant chemotherapy in locally advanced breast cancer. Br J Cancer 2004, 91(3), 434-440.
28. Rai, A.; Rajeshkumar, N. V.; Gulati, A. Effect of the et (B) receptor agonist, IRL-1620, on paclitaxel plasma pharmacokinetics of breast tumor rats. Exp Biol Med (Maywood) 2006, 231(6), 1120-1122.
29. Yamashita, J.; Ogawa, M.; Nomura, K.; Matsuo, S.; Inada, K.; Yamashita, S.; Nakashima, Y.; Saishoji, T.; Takano, S.; Fujita, S. Interleukin 6 stimulates the production of immunoreactive endothelin 1 in human breast cancer cells. Cancer Res 1993, 53(3), 464-467.
30. Li, C. Y.; Shan, S.; Huang, Q.; Braun, R. D.; Lanzen, J.; Hu, K.; Lin, P.; Dewhirst, M. W. Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models. J Natl Cancer Inst 2000, 92(2), 143-147.
31. Aslakson, C. J.; Miller, F. R. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res 1992, 52(6), 1399-1405.
32. Inokuchi, M.; Ninomiya, I.; Tsugawa, K.; Terada, I.; Miwa, K. Quantitative evaluation of metastases in axillary lymph nodes of breast cancer. Br J Cancer 2003, 89(9), 1750-1756.
33. Pfaffl, M. W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29(9), e45.
34. Lebret, S. C.; Newgreen, D. F.; Thompson, E. W.; Ackland, M. L. Induction of epithelial to mesenchymal transition in PMC42-LA human breast carcinoma cells by carcinoma-associated fibroblast secreted factors. Breast Cancer Res 2007, 9(1), R19.
35. Salani, D.; Taraboletti, G.; Rosano, L. Di Castro, V.; Borsotti, P.; Giavazzi, R.; Bagnato, A. Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Am J Pathol 2000, 157(5), 1703-1711.
36. Liang, Y.; Eid, M. A.; El Etreby, F.; Lewis, R. W.; Kumar, M. V. Mifepristone-induced secretion of transforming growth factor beta1-induced apoptosis in prostate cancer cells. Int J Oncol 2002, 21(6), 1259-1267.
37. Liang, C. C.; Park, A. Y.; Guan, J. L. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2007, 2(2), 329-333.
38. Bonacci, G. R.; Caceres, L. C.; Sanchez, M. C.; Chiabrando, G. A. Activated alpha (2)-macroglobulin induces cell proliferation and mitogen-activated protein kinase activation by LRP-1 in the J774 macrophage-derived cell line. Arch Biochem Biophys 2007, 460(1), 100-106.
39. Huang, G.; Hu, Z.; Li, M.; Cui, Y.; Li, Y.; Guo, L.; Jiang, W.; Lu, S. H. ECRG2 inhibits cancer cell migration, invasion and metastasis through the down-regulation of uPA/plasmin activity. Carcinogenesis 2007, 28(11), 2274-2281.
40. Akhtari, M.; Mansuri, J.; Newman, K. A.; Guise, T. M.; Seth, P. Biology of breast cancer bone metastasis. Cancer Biol Ther 2008, 7(1), 3-9.
41. Spyridopoulos, I.; Brogi, E.; Kearney, M.; Sullivan, A. B.; Cetrulo, C.; Isner, J. M.; Losordo, D. W. Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: balance between growth and death signals. J Mol Cell Cardiol 1997, 29(5), 1321-1330.
42. Bagnato, A.; Rosano, L. The endothelin axis in cancer. Int J Biochem Cell Biol 2008, 40(8), 1443-1451.
43. Binder, C.; Hagemann, T.; Sperling, S.; Schulz, M.; Pukrop, T.; Grimshaw, M. J.; Ehrenreich, H. Stromal endothelin B receptordeficiency inhibits breast cancer growth and metastasis. Mol Cancer Ther 2009, 8(8), 2452-2460.
44. Berger, Y.; Bernasconi, C. C.; Juillerat-Jeanneret, L. Targeting the endothelin axis in human melanoma: combination of endothelin receptor antagonism and alkylating agents. Exp Biol Med (Maywood) 2006, 231(6), 1111-1119.
45. Smollich, M.; Wulfing, P. The endothelin axis: a novel target for pharmacotherapy of female malignancies. Curr Vasc Pharmacol 2007, 5(3), 239-248.
46. Lissoni, P.; Malugani, F.; Bonfanti, A.; Bucovec, R.; Secondino, S.; Brivio, F.; Ferrari-Bravo, A.; Ferrante, R.; Vigore, L.; Rovelli F.; Mandalá, M.; Viviani, S.; Fumagalli, L.; Gardani, G. S. Abnormally enhanced blood concentrations of vascular endothelial growth factor (VEGF) in metastatic cancer patients and their relation to circulating dendritic cells, IL-12 and endothelin-1. J Biol Regul Homeost Agents 2001, 15(2), 140-144.
47. Ruetten, H.; Thiemermann, C. Endothelin-1 stimulates the biosynthesis of tumour necrosis factor in macrophages: ET-receptors, signal transduction and inhibition by dexamethasone. J Physiol Pharmacol 1997, 48(4), 675-688.
48. Le Brun, G.; Aubin, P.; Soliman, H.; Ropiquet, F.; Villette, J. M.; Berthon, P.; Creminon, C.; Cussenot, O.; Fiet, J. Upregulation of endothelin 1 and its precursor by IL-1beta, TNF-alpha, and TGF-beta in the PC3 human prostate cancer cell line. Cytokine 1999, 11(2), 157-162.
49. Coulombe, M.; Battistini, B.; Stankova, J.; Pouliot, P.; Bissonnette, E. Y. Endothelins regulate mediator production of rat tissue-cultured mucosal mast cells. Up-regulation of Th1 and inhibition of Th2 cytokines. J Leukoc Biol 2002, 71(5), 829-836.
50. Mencarelli, M.; Pecorelli, A.; Carbotti, P.; Valacchi, G.; Grasso, G.; Muscettola, M. Endothelin receptor A expression in human inflammatory cells. Regul Pept 2009, 158, 1-5.
51. Lambert, L. A.; Whyteside, A. R.; Turner, A. J.; Usmani, B. A. Isoforms of endothelin-converting enzyme-1 (ECE-1) have opposing effects on prostate cancer cell invasion. Br J Cancer 2008, 99(7), 1114-1120.
52. Stankova, J.; D'Orleans-Juste, P.; Rola-Pleszczynski, M. ET-1 induces IL-6 gene expression in human umbilical vein endothelial cells: synergistic effect of IL-1. Am J Physiol 1996, 271 (4 Pt 1), C1073-C1078.
53. Murri, A. A.; Hilmy, M.; Bell, J.; Wilson, C.; McNicol, A. M.; Lannigan, A.; Doughty, J. C.; McMillan, D. C. The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic and macrophage infiltration, microvessel density and survival in patients with primary operable breast cancer. Br J Cancer 2008, 99(7), 1013-1019.
54. Lin, E. Y.; Li, J. F.; Gnatovskiy, L.; Deng, Y.; Zhu, L.; Grzesik, D. A.; Qian, H.; Xue, X. N.; Pollard, J. W. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res 2006, 66(23), 11238-11246.
55. Okazaki, M.; Yoshimura, K.; Uchida, G.; Harii, K. Correlation between age and the secretions of melanocyte-stimulating cytokines in cultured keratinocytes and fibroblasts. Br J Dermatol 2005, 153 (Suppl 2), 23-29.
56. Maestroni, G. J. Therapeutic potential of melatonin in immunodeficiency states, viral diseases, and cancer. Adv Exp Med Biol 1999, 467, 217-226.
57. Lyon, D. E.; McCain, N. L.; Walter, J.; Schubert, C. Cytokine comparisons between women with breast cancer and women with a negative breast biopsy. Nurs Res 2008, 57(1), 51-58.
58. Ma, X. J.; Wang, Z.; Ryan, P. D.; Isakoff, S. J.; Barmettler, A.; Fuller, A.; Muir, B.; Mohapatra, G.; Salunga, R.; Tuggle, J. T. and others. A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell 2004, 5(6), 607-616.
59. Nam, J. S.; Terabe, M.; Kang, M. J.; Chae, H.; Voong, N.; Yang, Y. A.; Laurence, A.; Michalowska, A.; Mamura, M.; Lonning S. and others. Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17. Cancer Res 2008, 68(10), 3915-3923.
60. Shimozato, O.; Ugai, S.; Chiyo, M.; Takenobu, H.; Nagakawa, H.; Wada, A.; Kawamura, K.; Yamamoto, H.; Tagawa, M. The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effects. Immunology 2006, 117(1), 22-28.
61. Hoeve, M. A.; Savage, N. D.; de Boer, T.; Langenberg, D. M.; de Waal Malefyt, R.; Ottenhoff, T. H.; Verreck, F. A. Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur J Immunol 2006, 36(3), 661-670.