Circulating cell-free serum DNA: Significance as a new biomarker for urological malignancies;Zellfreie DNA im Blut: Bedeutung als neuer Biomarker für urologische Malignome

Urologe - Ausgabe A

Volumn 49, Issue 9, 2010, Pages 1131-1134

  Ellinger, J ^a   Von Rucker A ^a   Bastian, P J ^b   Muller S C ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Biomarker; Epigenetics; Prostate cancer

Indexed keywords

BIOLOGICAL MARKER; DNA;

CANCER PATIENT; CELL FREE SYSTEM; DISEASE MARKER; EPIGENETICS; HUMAN; SENSITIVITY AND SPECIFICITY; SHORT SURVEY; URINARY TRACT CANCER;

CELL-FREE SYSTEM; DIAGNOSTIC TECHNIQUES, UROLOGICAL; DNA, NEOPLASM; HUMANS; TUMOR MARKERS, BIOLOGICAL; UROLOGIC NEOPLASMS;

EID: 77958010785     PISSN: 03402592     EISSN: 14330563     Source Type: Journal    
DOI: 10.1007/s00120-010-2342-4     Document Type: Short Survey

References (23)

1. Goebell PJ, Keck B, Wach S, Wullich B (2010) Value of biomarkers In urology. Urologe A 49: 547-559
2. Mandel P, Metais P (1948) Les acides nucleiques du plasma sanguine chez l'homme. C R Acad Sci Paris 142: 241-243
3. Leon SA, Shapiro B, Sklaroff DM, Yarns MJ (1977) Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 37: 646-650 (Pubitemid 8051621)
4. Ellinger J, Muller SC, Stadler TC et al (2009) The role of cell-free circulating DNA in the diagnosis and prognosis of prostate cancer. Urol Oncol 182: 324-329
5. Garcia-Olmo DC, Dominguez C, Garcia-Arranz M et al (2010) Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells. Cancer Res 70: 560-567
6. Jung K, Stephan C, Lewandowski M et al (2004) Increased cell-free DNA in plasma of patients with metastatic spread in prostate cancer. Cancer Lett 205: 173-180 (Pubitemid 38230124) (Pubitemid 38230124)
7. Papadopoulou E, Davilas E, Sotiriou V et al (2004) Cell-free DNA and RNA in plasma as a new molecular marker for prostate cancer. Oncol Res 14: 439-445 (Pubitemid 39304311)
8. Allen D, Butt A, Cahill D et al (2004) Role of cell-free plasma DNA as a diagnostic marker for prostate cancer. Ann N Y Acad Sci 1022: 76-80 (Pubitemid 38951585) (Pubitemid 38951585)
9. Boddy JL, Gal S, Malone PR et al (2005) Prospective study of quantitation of plasma DNA levels In the diagnosis of malignant versus benign prostate disease. Clin Cancer Res 11: 1394-1399 (Pubitemid 40315218) (Pubitemid 40315218)
10. Chun FK, Muller I, Lange I et al (2006) Circulating tumour-associated plasma DNA represents an independent and informative predictor of prostate cancer. BJU Int 98: 544-548 (Pubitemid 44185873) (Pubitemid 44185873)
11. Mehra N, Penning M, Maas J et al (2007) Circulating mitochondrial nucleic acids have prognostic value for survival in patients with advanced prostate cancer. Clin Cancer Res 13: 421-426 (Pubitemid 46225345) (Pubitemid 46225345)
12. Ellinger J, Bastian PJ, Haan Kl et al (2008) Noncancerous PTGS2 DNA fragments of apoptotic origin in sera of prostate cancer patients qualify as diagnostic and prognostic indicators, Int J Cancer 122: 138-143 (Pubitemid 350209988) (Pubitemid 350209988)
13. Ellinger J, Mueller SC, Wernert N et al (2008) Mitochondrial DNA in serum of patients with prostate cancer: a predictor of biochemical recurrence following prostatectomy, BJU Int 102: 628-632
14. Altimari A, Grigioni AD, Benedettini E et al (2008) Diagnostic rale of circulating free plasma DNA detection in patients with localized prostate cancer. Am J Clin Pathol 129: 756-762
15. Cherepanova AV, Tamkovich SN, Bryzgunova OE et al (2008) Deoxyribonuclease activity and circulating DNA concentration in blood plasma of patients with prostate tumors. Ann N Y Acad Sci 1137: 218-221
16. Schwarzenbach H, Alix-Panabieres C, Muller I et al (2009) Cell-free Tumor DNA in blood plasma as a marker for circulating tumor cells In prostate cancer. Clin Cancer Res 15: 1032-1038
17. Bastian PJ, Palapattu GS, Yegnasubramanian S et al (2007) Prognostic value of preoperative serum cell-free circulating DNA in men with prostate cancer undergoing radical prostatectomy. Clin Cancer Res 13: 5361-5367 (Pubitemid 47510361) (Pubitemid 47510361)
18. Ellinger J, Bastian PJ, Ellinger N et al (2008) Apoptotic DNA fragments in serum of patients with muscle invasive bladder cancer: A prognostic entity. Cancer Lett 264: 274-280
19. Ellinger J, Müller DC, Mueller SC et al (2010) Circulating mitochondrial DNA in serum: A universal diagnostic biomarker for patients with urological malignancies. 10.1016/j.urolonc.2010.03.004 [Epub ahead]
20. Gang F, Guorong L, An Z et al (2010) Prediction of clear cell renal cell carcinoma by integrity of Cellfree DNA In Serum. Urology 75: 262-265
21. Ellinger J, Wittkamp V, Albers P et al (2009) Cellfree circulating DNA: diagnostic value in patients with testicular germ cell cancer. J Urol 181: 363-371
22. Ellinger J, Albers P, Muller SC et al (2009) Circulating mitochondrial DNA in the serum of patients with testicular germ cell cancer as a novel noninvasive diagnostic biomarker. BJU Int 104: 48-52
23. Hauser S, Zahalka T, Ellinger J et al. (2010) Cell free circulating DNA: Diagnostic value in patients with renal cell cancer. Anticancer Res (in press)