Delayed stress-induced differences in locomotor and depression-related behaviour in female neuropeptide-Y Y1 receptor knockout mice

Journal of Psychopharmacology

Volumn 24, Issue 10, 2010, Pages 1541-1549

  Painsipp, E ^a   Sperk, G ^b   Herzog, H ^c   Holzer, P ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

anxiety like behaviour; depression like behaviour; locomotor activity; neuropeptide Y; neuropeptide Y Y1 receptors; stress sensitivity; thermal nociception

Indexed keywords

CORTICOSTERONE; NEUROPEPTIDE Y; NEUROPEPTIDE Y1 RECEPTOR;

ADAPTATION; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BEHAVIOR CHANGE; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; EMOTION; FEMALE; FOOTSHOCK; FORCED SWIMMING TEST; IMMOBILIZATION; LOCOMOTION; MAZE TEST; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; STRESS; STRESS MANAGEMENT; TAIL SUSPENSION TEST; WITHDRAWAL REFLEX;

ANALGESIA; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; CORTICOSTERONE; DEPRESSION; FEMALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; NEUROPEPTIDE Y; PAIN MEASUREMENT; REACTION TIME; RECEPTORS, NEUROPEPTIDE Y; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; STRESS, PSYCHOLOGICAL; TIME FACTORS;

EID: 77958002072     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881109104851     Document Type: Article

References (55)

1. Adriaan Bouwknecht, J., Olivier, B., Paylor, RE (2007) The stress-induced hyperthermia paradigm as a physiological animal model for anxiety: a review of pharmacological and genetic studies in the mouse. Neurosci Biobehav Rev 31: 41-59.
2. Belzung, C., Griebel, G. (2001) Measuring normal and pathological anxiety-like behaviour in mice: a review. Behav Brain Res 125: 141-149.
3. Chotiwat, C., Harris, RB (2006) Increased anxiety-like behavior during the post-stress period in mice exposed to repeated restraint stress. Horm Behav 50: 489-495.
4. Cryan, JF, Markou, A., Lucki, I. (2002) Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci 23: 238-245.
5. Cryan, JF, Mombereau, C., Vassout, A. (2005) The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci Biobehav Rev 29: 571-625.
6. Dimitrov, EL, DeJoseph, MR, Brownfield, MS, Urban, JH (2007) Involvement of neuropeptide Y Y1 receptors in the regulation of neuroendocrine corticotropin-releasing hormone neuronal activity. Endocrinology 148: 3666-3673.
7. Dumont, Y., Jacques, D., Bouchard, P., Quirion, R. (1998) Species differences in the expression and distribution of the neuropeptide Y Y1, Y2, Y4, and Y5 receptors in rodents, guinea pig, and primates brains. J Comp Neurol 402: 372-384.
8. Eva, C., Serra, M., Mele, P., Panzica, G., Oberto, A. (2006) Physiology and gene regulation of the brain NPY Y1 receptor. Front Neuroendocrinol 27: 308-339.
9. Fetissov, SO, Kopp, J., Hökfelt, T. (2004) Distribution of NPY receptors in the hypothalamus. Neuropeptides 38: 175-188.
10. Gorman, JM (2006) Gender differences in depression and response to psychotropic medication. Gend Med 3: 93-109.
11. Heilig, M. (2004) The NPY system in stress, anxiety and depression. Neuropeptides 38: 213-224.
12. Howell, OW, Scharfman, HE, Herzog, H., Sundstrom, LE, Beck-Sickinger, A., Gray, WP (2003) Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells. J Neurochem 86: 646-659.
13. Imbe, H., Iwai-Liao, Y., Senba, E. (2006) Stress-induced hyperalgesia: animal models and putative mechanisms. Front Biosci 11: 2179-2192.
14. Ishihara, A., Kanatani, A., Okada, M., Hidaka, M., Tanaka, T., Mashiko, S., et al. (2002) Blockade of body weight gain and plasma corticosterone levels in Zucker fatty rats using an orally active neuropeptide Y Y1 antagonist. Br J Pharmacol 136: 341-346.
15. Karl, T., Burne, TH, Herzog, H. (2006) Effect of Y1 receptor deficiency on motor activity, exploration, and anxiety. Behav Brain Res 167: 87-93.
16. Karl, T., Herzog, H. (2007) Behavioral profiling of NPY in aggression and neuropsychiatric diseases. Peptides 28: 326-333.
17. Karl, T., Lin, S., Schwarzer, C., Sainsbury, A., Couzens, M., Wittmann, W., et al. (2004) Y1 receptors regulate aggressive behavior by modulating serotonin pathways. Proc Natl Acad Sci U S A 101: 12742-12747.
18. Karlsson, RM, Choe, JS, Cameron, HA, Thorsell, A., Crawley, JN, Holmes, A., et al. (2008) The neuropeptide Y Y1 receptor subtype is necessary for the anxiolytic-like effects of neuropeptide Y, but not the antidepressant-like effects of fluoxetine, in mice. Psychopharmacology (Berl) 195: 547-557.
19. Kask, A., Eller, M., Oreland, L., Harro, J. (2000) Neuropeptide Y attenuates the effect of locus coeruleus denervation by DSP-4 treatment on social behaviour in the rat. Neuropeptides 34: 58-61.
20. Kask, A., Harro, J., von Hörsten, S., Redrobe, JP, Dumont, Y., Quirion, R. (2002) The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. Neurosci Biobehav Rev 26: 259-283.
21. Kask, A., Nguyen, HP, Pabst, R., von Hörsten, S. (2001) Neuropeptide Y Y1 receptor-mediated anxiolysis in the dorsocaudal lateral septum: functional antagonism of corticotropin-releasing hormone-induced anxiety. Neuroscience 104: 799-806.
22. Kask, A., Rägo, L., Harro, J. (1996) Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. Eur J Pharmacol 317: R3 - R4.
23. Kask, A., Rägo, L., Harro, J. (1998) Anxiogenic-like effect of the NPY Y1 receptor antagonist BIBP3226 administered into the dorsal periaqueductal gray matter in rats. Regul Pept 75-76: 255-262.
24. Kirk, RE (1995) Experimental Design. Procedures for the Behavioral Sciences, third ed. Pacific Grove, California: Brooks / Cole.
25. Kopp, J., Xu, ZQ, Zhang, X., Pedrazzini, T., Herzog, H., Kresse, A., et al. (2002) Expression of the neuropeptide Y Y1 receptor in the CNS of rat and of wild-type and Y1 receptor knock-out mice. Focus on immunohistochemical localization. Neuroscience 111: 443-532.
26. Lin, S., Boey, D., Herzog, H. (2004) NPY and Y receptors: lessons from transgenic and knockout models. Neuropeptides 38: 189-200.
27. Liu, X., Gershenfeld, HK (2001) Genetic differences in the tail-suspension test and its relationship to imipramine response among 11 inbred strains of mice. Biol Psychiatry 49: 575-581.
28. Mele, P., Oberto, A., Serra, M., Pisu, MG, Floris, I., Biggio, G., et al. (2004) Increased expression of the gene for the Y1 receptor of neuropeptide Y in the amygdala and paraventricular nucleus of Y1R/ LacZ transgenic mice in response to restraint stress. J Neurochem 89: 1471-1478.
29. Michel, MC, Beck-Sickinger, A., Cox, H., Doods, HN, Herzog, H., Larhammar, D., et al. (1998) XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol Rev 50: 143-150.
30. Mogil, JS, Richards, SP, O'Toole, LA, Helms, ML, Mitchell, SR, Kest, B., et al. (1997) Identification of a sex-specific quantitative trait locus mediating nonopioid stress-induced analgesia in female mice. J Neurosci 17: 7995-8002.
31. Montagne-Clavel, J., Oliveras, JL (1996) The "plantar test" apparatus (Ugo Basile Biological Apparatus). a controlled infrared noxious radiant heat stimulus for precise withdrawal latency measurement in the rat, as a tool for humans? Somatosens Mot Res 13: 215-223.
32. Naveilhan, P., Hassani, H., Lucas, G., Blakeman, KH, Hao, JX, Xu, XJ, et al. (2001) Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor. Nature 409: 513-517.
33. Painsipp, E., Wultsch, T., Shahbazian, A., Edelsbrunner, M., Kreissl, MC, Schirbel, A., et al. (2007) Experimental gastritis in mice enhances anxiety in a gender-related manner. Neuroscience 150: 522-536.
34. Palanza, P. (2001) Animal models of anxiety and depression: how are females different ? Neurosci Biobehav Rev 25: 219-233.
35. Parker, RM, Herzog, H. (1999) Regional distribution of Y-receptor subtype mRNAs in rat brain. Eur J Neurosci 11: 1431-1448.
36. Paylor, R., Spencer, CM, Yuva-Paylor, LA, Pieke-Dahl, S. (2006) The use of behavioral test batteries, II: effect of test interval. Physiol Behav 87: 95-102.
37. Pellow, S., File, SE (1986) Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 24: 525-529. (Pubitemid 16145187)
38. Primeaux, SD, Wilson, SP, Cusick, MC, York, DA, Wilson, MA (2005) Effects of altered amygdalar neuropeptide Y expression on anxiety-related behaviors. Neuropsychopharmacology 30: 1589-1597.
39. Raposinho, PD, Pedrazzini, T., White, RB, Palmiter, RD, Aubert, ML (2004) Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression. Endocrinology 145: 304-310.
40. Redrobe, JP, Carvajal, C., Kask, A., Dumont, Y., Quirion, R. (2004) Neuropeptide Y and its receptor subtypes in the central nervous system: emphasis on their role in animal models of psychiatric disorders. In: Michel, MC (ed). Neuropeptide Y and Related Peptides. Handbook of Experimental Pharmacology, vol. 162. Berlin: Springer, pp. 101-136.
41. Redrobe, JP, Dumont, Y., Fournier, A., Quirion, R. (2002) The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neuropsychopharmacology 26: 615-624.
42. Sainsbury, A., Schwarzer, C., Couzens, M., Fetissov, S., Fürtinger, S., Jenkins, A., et al. (2002 a) Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc Natl Acad Sci U S A 99: 8938-8943.
43. Sainsbury, A., Schwarzer, C., Couzens, M., Jenkins, A., Oakes, SR, Ormandy, CJ, et al. (2002 b) Y4 receptor knockout rescues fertility in ob/ob mice. Genes Dev 16: 1077-1088.
44. Sajdyk, TJ, Vandergriff, MG, Gehlert, DR (1999) Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test. Eur J Pharmacol 368: 143-147.
45. Shi, TJ, Li, J., Dahlström, A., Theodorsson, E., Ceccatelli, S., Decosterd, I., et al. (2006) Deletion of the neuropeptide Y Y1 receptor affects pain sensitivity, neuropeptide transport and expression, and dorsal root ganglion neuron numbers. Neuroscience 140: 293-304.
46. Simonds, VM, Whiffen, VE (2003) Are gender differences in depression explained by gender differences in co-morbid anxiety ? J Affect Disord 77: 197-202.
47. Stam, R. (2007) PTSD and stress sensitisation: a tale of brain and body. Part 2: animal models. Neurosci Biobehav Rev 31: 558-584. (Pubitemid 46527884)
48. Stam, R., Croiset, G., Bruijnzeel, AW, Visser, TJ, Akkermans, LM, Wiegant, VM (1999) Sex differences in long-term stress-induced colonic, behavioural and hormonal disturbances. Life Sci 65: 2837-2849.
49. Steru, L., Chermat, R., Thierry, B., Simon, P. (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl) 85: 367-370.
50. Thorsell, A., Carlsson, K., Ekman, R., Heilig, M. (1999) Behavioral and endocrine adaptation, and up-regulation of NPY expression in rat amygdala following repeated restraint stress. Neuroreport 10: 3003-3007.
51. Thorsell, A., Svensson, P., Wiklund, L., Sommer, W., Ekman, R., Heilig, M. (1998) Suppressed neuropeptide Y (NPY) mRNA in rat amygdala following restraint stress. Regul Pept 75-76: 247-254.
52. Vezzani, A., Sperk, G., Colmers, WF (1999) Neuropeptide Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci 22: 25-30.
53. Wittmann, W., Loacker, S., Kapeller, I., Herzog, H., Schwarzer, C. (2005) Y1-receptors regulate the expression of Y2-receptors in distinct mouse forebrain areas. Neuroscience 136: 241-250.
54. Yamada, K., Nabeshima, T. (1995) Stress-induced behavioral responses and multiple opioid systems in the brain. Behav Brain Res 67: 133-145.
55. Zhou, Z., Zhu, G., Hariri, AR, Enoch, MA, Scott, D., Sinha, R., et al. (2008) Genetic variation in human NPY expression affects stress response and emotion. Nature 452: 997-1001.