Whole brain and regional hyperintense white matter volume and blood pressure: Overlap of genetic loci produced by bivariate, whole-genome linkage analyses

Stroke

Volumn 41, Issue 10, 2010, Pages 2137-2142

  Kochunov, Peter ^a,c   Glahn, David ^a,b   Lancaster, Jack ^a,b   Winkler, Anderson ^a,b   Kent, Jack W ^c   Olvera, Rene L ^a   Cole, Shelley A ^c   Dyer, Thomas D ^c   Almasy, Laura ^c   Duggirala, Ravi ^c   Fox, Peter T ^a   Blangero, John ^c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

brain; brain imaging; genetics; hypertension; leukoaraiosis; leukoencephalopathy; magnetic resonance; MRI

Indexed keywords

BIOLOGICAL MARKER; DNA;

ADULT; ARTICLE; BIVARIATE ANALYSIS; BRAIN SIZE; CHROMOSOME 10Q; CHROMOSOME 15Q; CHROMOSOME 1Q; EPENDYMA; ETHNIC GROUP; FEMALE; GENE LOCUS; GENETIC LINKAGE; GENOME; GENOTYPE; HERITABILITY; HUMAN; HUMAN EXPERIMENT; HYPERINTENSE WHITE MATTER; LINKAGE ANALYSIS; MALE; MEXICAN AMERICAN; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; POST HOC ANALYSIS; PRIORITY JOURNAL; PULSE PRESSURE; QUANTITATIVE TRAIT LOCUS; SYSTOLIC BLOOD PRESSURE; UNITED STATES; WHITE MATTER; AGED; BLOOD PRESSURE; BRAIN; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; MYELINATED NERVE; ORGAN SIZE; PATHOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BLOOD PRESSURE; BRAIN; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LINKAGE (GENETICS); LOD SCORE; MAGNETIC RESONANCE IMAGING; MALE; MEXICAN AMERICANS; MIDDLE AGED; NERVE FIBERS, MYELINATED; ORGAN SIZE; GENETIC LINKAGE;

EID: 77957994041     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.110.590943     Document Type: Article

References (31)

1. Kochunov P, Thompson PM, Coyle TR, Lancaster JL, Kochunov V, Royall D, Mangin JF, Riviere D, Fox PT. Relationship among neuro-imaging indices of cerebral health during normal aging. Hum Brain Mapp. 2008;29:36-45.
2. Carmelli D, DeCarli C, Swan GE, Jack LM, Reed T, Wolf PA, Miller BL. Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins. Stroke. 1998;29:1177-1181.
3. Reed T, Kirkwood SC, DeCarli C, Swan GE, Miller BL, Wolf PA, Jack LM, Carmelli D. Relationship of family history scores for stroke and hypertension to quantitative measures of white-matter hyperintensities and stroke volume in elderly males. Neuroepidemiology. 2000;19:76-86.
4. Turner ST, Fornage M, Jack CR Jr, Mosley TH, Kardia SL, Boerwinkle E, de Andrade M. Genomic susceptibility loci for brain atrophy in hypertensive sibships from the Genoa study. Hypertension. 2005;45: 793-798.
5. Kochunov P, Glahn D, Winkler A, Duggirala R, Olvera R, Cole SA, Dyer TD, Almasy L, Fox P, Blangero J. Analysis of genetic variability and whole genome linkage of whole-brain, subcortical and ependymal hyper-intense white matter volume. Stroke. 2009;40:3685-3690.
6. Kraut MA, Beason-Held LL, Elkins WD, Resnick SM. The impact of magnetic resonance imaging-detected white matter hyperintensities on longitudinal changes in regional cerebral blood flow. J Cereb Blood Flow Metab. 2008;28:190-197.
7. Kochunov P, Ramage AE, Lancaster JL, Robin DA, Narayana S, Coyle T, Royall DR, Fox P. Loss of cerebral white matter structural integrity tracks the gray matter metabolic decline in normal aging. Neuroimage. 2009;45:17-28.
8. Kochunov P, Robin D, Royall D, Lancaster J, Kochunov V, Coyle T, Schlosser A, Fox P. Can structural MRI cerebral health markers track cognitive trends in executive control function during normal maturation and adulthood? Hum Brain Mapp. 2009;30:2581-2594.
9. Galluzzi S, Lanni C, Pantoni L, Filippi M, Frisoni GB. White matter lesions in the elderly: pathophysiological hypothesis on the effect on brain plasticity and reserve. J Neurol Sci. 2008;273:3-9.
10. Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, Radner H, Lechner H. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology. 1993;43:1683-1689.
11. Bateman GA. Pulse-wave encephalopathy: a comparative study of the hydrodynamics of leukoaraiosis and normal-pressure hydrocephalus. Neuroradiology. 2002;44:740-748.
12. Nair GV, Chaput LA, Vittinghoff E, Herrington DM. Pulse pressure and cardiovascular events in postmenopausal women with coronary heart disease. Chest. 2005;127:1498-1506. (Pubitemid 46218772)
13. Miura K, Soyama Y, Morikawa Y, Nishijo M, Nakanishi Y, Naruse Y, Yoshita K, Kagamimori S, Nakagawa H. Comparison of four blood pressure indexes for the prediction of 10-year stroke risk in middle-aged and older Asians. Hypertension. 2004;44:715-720.
14. Rutherford S, Cai G, Lopez-Alvarenga JC, Kent JW, Voruganti VS, Proffitt JM, Curran JE, Johnson MP, Dyer TD, Jowett JB, Bastarrachea RA, Atwood LD, Goring HH, Maccluer JW, Moses EK, Blangero J, Comuzzie AG, Cole SA. A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study. Am J Hum Genet. 2007;81:744-755.
15. Mitchell BD, Kammerer CM, Blangero J, Mahaney MC, Rainwater DL, Dyke B, Hixson JE, Henkel RD, Sharp RM, Comuzzie AG, VandeBerg JL, Stern MP, MacCluer JW. Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans. The San Antonio Family Heart Study. Circulation. 1996;94:2159-2170.
16. Henry Feugeas MC, De Marco G, Peretti II, Godon-Hardy S, Fredy D, Claeys ES. Age-related cerebral white matter changes and pulse-wave encephalopathy: observations with three-dimensional MRI. Magn Reson Imaging. 2005;23:929-937.
17. Kammerer CM, Schneider JL, Cole SA, Hixson JE, Samollow PB, O'Connell JR, Perez R, Dyer TD, Almasy L, Blangero J, Bauer RL, Mitchell BD. Quantitative trait loci on chromosomes 2p, 4p, and 13q influence bone mineral density of the forearm and hip in Mexican Americans. J Bone Miner Res. 2003;18:2245-2252.
18. Goring HH, Curran JE, Johnson MP, Dyer TD, Charlesworth J, Cole SA, Jowett JB, Abraham LJ, Rainwater DL, Comuzzie AG, Mahaney MC, Almasy L, MacCluer JW, Kissebah AH, Collier GR, Moses EK, Blangero J. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat Genet. 2007;39:1208-1216.
19. Almasy L, Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet. 1998;62:1198-1211.
20. Zee RY, Cook NR, Cheng S, Reynolds R, Erlich HA, Lindpaintner K, Ridker PM. Polymorphism in the p-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis. Hum Mol Genet. 2004;13:389-396.
21. Blann AD, Nadar SK, Lip GY. The adhesion molecule p-selectin and cardiovascular disease. Eur Heart J. 2003;24:2166-2179.
22. Preston RA, Coffey JO, Materson BJ, Ledford M, Alonso AB. Elevated platelet p-selectin expression and platelet activation in high risk patients with uncontrolled severe hypertension. Atherosclerosis. 2007;192: 148-154.
23. Duggirala R, Blangero J, Almasy L, Dyer TD, Williams KL, Leach RJ, O'Connell P, Stern MP. A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans. Am J Hum Genet. 2000;66:1237-1245.
24. Browning BL, Browning SR. Haplotypic analysis of Wellcome Trust case control consortium data. Hum Genet. 2008;123:273-280.
25. Wang WY, Glenn CL, Zhang W, Benjafield AV, Nyholt DR, Morris BJ. Exclusion of angiotensinogen gene in molecular basis of human hypertension: sibpair linkage and association analyses in Australian Anglo-Caucasians. Am J Med Genet. 1999;87:53-60.
26. Blangero J, Williams JT, Almasy L. Novel family-based approaches to genetic risk in thrombosis. J Thromb Haemost. 2003;1:1391-1397.
27. Bateman GA. Pulse wave encephalopathy: a spectrum hypothesis incorporating Alzheimer's disease, vascular dementia and normal pressure hydrocephalus. Med Hypotheses. 2004;62:182-187.
28. Zhang Q, Lewis CE, Wagenknecht LE, Myers RH, Pankow JS, Hunt SC, North KE, Hixson JE, Jeffrey Carr J, Shimmin LC, Borecki I, Province MA. Genome-wide admixture mapping for coronary artery calcification in African Americans: the NHLBI Family Heart Study. Genet Epidemiol. 2008;32:264-272.
29. Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998;78:547-581.
30. Bartzokis G, Sultzer D, Lu PH, Nuechterlein KH, Mintz J, Cummings JL. Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical 'disconnection' in aging and Alzheimer's disease. Neurobiol Aging. 2004;25:843-851.
31. Walhovd KB, Fjell AM, Brewer J, McEvoy LK, Fennema-Notestine C, Hagler DJ Jr, Jennings RG, Karow D, Dale AM. Combining MR imaging, positron-emission tomography, and CSF biomarkers in the diagnosis and prognosis of Alzheimer disease. AJNR Am J Neuroradiol. 31:347-354.