Review: 17α-Hydroxylase (CYP17) Expression and Subsequent Androstenedione Production in the Human Ovary

Reproductive Sciences

Volumn 17, Issue 11, 2010, Pages 978-986

  Patel, Satin S ^a   Beshay, Victor E ^a   Escobar, Julian C ^a   Carr, Bruce R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

androgen; c Fos; CYP17; granulosa; theca

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANDROSTENEDIONE; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN C FOS; PROTEIN KINASE C; STEROID 17ALPHA MONOOXYGENASE; TRANSCRIPTION FACTOR AP 1; CYP17A1 PROTEIN, HUMAN;

ADRENAL GLAND; ANDROGEN SYNTHESIS; ANDROGENESIS; CELL COMPARTMENTALIZATION; CELL ISOLATION; CELL STIMULATION; ENZYME INHIBITION; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; GRANULOSA CELL; HUMAN; IMMUNOHISTOCHEMISTRY; NONHUMAN; ONCOGENE C FOS; OVARY; OVARY FOLLICLE CELL; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RNA EXTRACTION; SIGNAL TRANSDUCTION; STEROIDOGENESIS; THECA CELL; ZONA GLOMERULOSA; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

ANDROSTENEDIONE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; OVARY; STEROID 17-ALPHA-HYDROXYLASE;

EID: 77957991914     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719110379055     Document Type: Review

References (22)

1. Suzuki T., Sasano H., Tamura M., et al. Temporal and spatial localization of steroidogenic enzymes in premenopausal human ovaries: in situ hybridization and immunohistochemical study. Mol Cell Endocrinol. 1993 ; 97 (1-2). 135-143.
2. Short RV Steroids in the follicular fluid and the corpus luteum of the mare. A 'two-cell type' theory of ovarian steroid synthesis. J Endocrinol. 1962 ; 24: 59-63.
3. McNatty KP, Makris A., DeGrazia C., Osathanondh R., Ryan KJ The production of progesterone, androgens, and estrogens by granulosa cells, thecal tissue, and stromal tissue from human ovaries in vitro. J Clin Endocrinol Metab. 1979 ; 49 (5). 687-699.
4. Carr BR, Blackwell RE, Azziz R. Essential Reproductive Medicine. New York, NY: McGraw-Hill, Medical Pub. Div ; 2005.
5. Carr BR, McGee EA, Sawetawan C., Clyne CD, Rainey WE The effect of transforming growth factor-beta on steroidogenesis and expression of key steroidogenic enzymes with a human ovarian thecal-like tumor cell model. Am J Obstet Gynecol. 1996 ; 174 (4). 1109-1116 ; discussion 1116-1107.
6. Daneshmand S., Weitsman SR, Navab A., Jakimiuk AJ, Magoffin DA Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side-chain cleavage and 17alphahydroxylase/C(17-20) lyase promoters. Fertil Steril. 2002 ; 77 (2). 274-280.
7. Nelson VL, Legro RS, Strauss JF 3rd, McAllister JM Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries. Mol Endocrinol. 1999 ; 13 (6). 946-957.
8. Wood JR, Dumesic DA, Abbott DH, Strauss JF 3rd. Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis. J Clin Endocrinol Metab. 2007 ; 92 (2). 705-713.
9. Beshay VE, Havelock JC, Sirianni R., et al. The mechanism for protein kinase C inhibition of androgen production and 17alpha-hydroxylase expression in a theca cell tumor model. J Clin Endocrinol Metab. 2007 ; 92 (12). 4802-4809.
10. Corbalan-Garcia S., Gomez-Fernandez JC Protein kinase C regulatory domains: the art of decoding many different signals in membranes. Biochim Biophys Acta. 2006 ; 1761 (7). 633-654.
11. Angel P., Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta. 1991 ; 1072 (2-3). 129-157.
12. Jansen E., Laven JS, Dommerholt HB, et al. Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients. Mol Endocrinol. 2004 ; 18 (12). 3050-3063.
13. Shea-Eaton W., Sandhoff TW, Lopez D., Hales DB, McLean MP Transcriptional repression of the rat steroidogenic acute regulatory (StAR) protein gene by the AP-1 family member c-Fos. Mol Cell Endocrinol. 2002 ; 188 (1-2). 161-170.
14. Jo Y., King SR, Khan SA, Stocco DM Involvement of protein kinase C and cyclic adenosine 3,'5'-monophosphate-dependent kinase in steroidogenic acute regulatory protein expression and steroid biosynthesis in Leydig cells. Biol Reprod. 2005 ; 73 (2). 244-255.
15. Guo IC, Huang CY, Wang CK, Chung BC Activating protein-1 cooperates with steroidogenic factor-1 to regulate 3,'5'-cyclic adenosine 5'-monophosphate- dependent human CYP11A1 transcription in vitro and in vivo. Endocrinology. 2007 ; 148 (4). 1804-1812.
16. Patel SS, Beshay VE, Escobar JC, Suzuki T., Carr BR Molecular mechanism for repression of 17alpha-hydroxylase expression and androstenedione production in granulosa cells. J Clin Endocrinol Metab. 2009 ; 94 (12). 5163-5168.
17. Oktay M., Wary KK, Dans M., Birge RB, Giancotti FG Integrinmediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. J Cell Biol. 1999 ; 145 (7). 1461-1469.
18. Oktay KH, Oktay MH. Immunohistochemical analysis of tyrosine phosphorylation and AP-1 transcription factors c-Jun, Jun D, and Fos family during early ovarian follicle development in the mouse. Appl Immunohistochem Mol Morphol. 2004 ; 12 (4). 364-369.
19. Wickenheisser JK, Quinn PG, Nelson VL, Legro RS, Strauss JF 3rd, McAllister JM Differential activity of the cytochrome P450 17alpha-hydroxylase and steroidogenic acute regulatory protein gene promoters in normal and polycystic ovary syndrome theca cells. J Clin Endocrinol Metab. 2000 ; 85 (6). 2304-2311.
20. Woods DC, Haugen MJ, Johnson AL Actions of epidermal growth factor receptor/mitogen-activated protein kinase and protein kinase C signaling in granulosa cells from Gallus gallus are dependent upon stage of differentiation. Biol Reprod. 2007 ; 77 (1). 61-70.
21. Cheng RX, Feng DY, Zheng H., Tan Y. [Effect of activation of p-MAPK on activating c-fos and c-jun proteins in breast cancer]. Hunan Yi Ke Da Xue Xue Bao. 2001 ; 26 (1). 10-12.
22. Dharia S., Slane A., Jian M., Conner M., Conley AJ, Parker CR Jr. Colocalization of P450c17 and cytochrome b5 in androgen-synthesizing tissues of the human. Biol Reprod. 2004 ; 71 (1). 83-88.