Towards a multiscale integrative model of WSS-induced signaling pathways in cerebral aneurysms

IFMBE Proceedings

Volumn 31 IFMBE, Issue , 2010, Pages 1159-1162

  Ho, H ^a   Cooling, M T ^a   Hunter, P ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Cerebral aneurysms; multiscale; signaling pathway; wall shear stress

Indexed keywords

BLOOD FLOW; CEREBRAL ANEURYSMS; COMPUTATIONAL APPROACH; COMPUTATIONAL MODEL; CT IMAGE; DIFFERENT SCALE; EXPERIMENTAL DATA; MULTIPLE PATHWAYS; MULTISCALES; SIGNALING PATHWAY; SIGNALING PATHWAYS; SUB-CELLULAR; WALL SHEAR STRESS;

BIOMECHANICS; BIOMEDICAL ENGINEERING; BIOPHYSICS; COMPUTERIZED TOMOGRAPHY; PIGMENTS; SHEAR STRESS; STRENGTH OF MATERIALS; TECHNICAL PRESENTATIONS; THREE DIMENSIONAL;

SIGNALING;

EID: 77957986698     PISSN: 16800737     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1007/978-3-642-14515-5_294     Document Type: Conference Paper

References (9)

1. Chien S. (2007) Mechanotransduction and endothelial cell homeostasis: The wisdom of the cell. Am J Physiol Heart Circ Physiol. 292(3):H1209-1224.
2. Cheng C, van Haperen R, de Waard M, et al. (2005) Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique. Blood. 106(12):3691-3698.
3. Balligand J, Feron O, Dessy C. (2009) eNOS Activation by Physical Forces: From Short-Term Regulation of Contraction to Chronic Remodeling of Cardiovascular Tissues. Physiol. Rev. 89(2):481-534.
4. Johanning JM, Armstrong PJ, Franklin DP, et al. (2002) Nitric Oxide in Experimental Aneurysm Formation: Early Events and Consequences of Nitric Oxide Inhibition. Annals of Vascular Surgery. 16(1):65-72.
5. Davies PF. (1995) Flow-mediated endothelial mechanotransduction. Physiol. Rev. 75(3):519-560.
6. Ho H. (2010) Computational Modelling of Cerebral Aneurysms. PhD Thesis. University of Auckland.
7. Cooling MT, Rouilly V, Misirli G, et al. (2010) Standard Virtual Biological Parts: A Repository of Modular Modeling Components for Synthetic Biology. Bioinformatics. btq063.
8. Comerford A, Plank MJ, David T. (2008) Endothelial Nitric Oxide Synthase and Calcium Production in Arterial Geometries: An Integrated Fluid Mechanics/Cell Model. J. Biomech. Eng. 130(1):011010-13.
9. Chen K, Popel AS. (2006) Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells. Free Radical Biology and Medicine. 41(4):668-680.