The Serotonin 5-HT2C receptor in medial prefrontal cortex exerts rheostatic control over the motivational salience of cocaine-associated cues: New observations from preclinical animal research

Neuropsychopharmacology

Volumn 35, Issue 12, 2010, Pages 2319-2321

  Cunningham, Kathryn A ^a   Bubar, Marcy J ^a   Anastasio, Noelle C ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; SEROTONIN 2C RECEPTOR; SEROTONIN 2 AGONIST;

ASSOCIATION; DRUG DEPENDENCE; HUMAN; MOTIVATION; NEUROTRANSMISSION; NONHUMAN; NOTE; PREFRONTAL CORTEX; PRIORITY JOURNAL; WITHDRAWAL SYNDROME; ANIMAL; ANIMAL MODEL; DRUG EFFECT; DRUG SEEKING BEHAVIOR; PHYSIOLOGY;

ANIMALS; COCAINE; DRUG-SEEKING BEHAVIOR; MODELS, ANIMAL; MOTIVATION; PREFRONTAL CORTEX; SEROTONIN 5-HT2 RECEPTOR AGONISTS;

EID: 77957986237     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2010.119     Document Type: Note

References (7)

1. 2C receptor protein expression is enriched in synaptosomal and post-synaptic compartments of rat cortex. J Neurochem 113: 1504-1515.
2. 2R pharmacotherapy in psychostimulant abuse. Prog Brain Res 172: 319-346.
3. Kalivas PW, Volkow ND (2005). The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 162: 1403-1413.
4. Nic Dhonnchadha BA, Cunningham KA (2008). Serotonergic mechanisms in addiction-related memories. Behav Brain Res 195: 39-53.
5. 2C) receptors attenuates cocaine-seeking behavior. Neuropsychopharmacol 35: 2037-2048.
6. 2C) receptor, in healthy male and female recreational polydrug users. Amer Coll Neuropsycho-pharmacol. 48th Annual Meeting, Hollywood, CA.
7. Smith SR, Prosser WA, Donahue DJ, Morgan ME, Anderson CM, Shanahan WR et al (2009). Lorcaserin (APD356), a selective 5-HT(2C) agonist, reduces body weight in obese men and women. Obesity (Silver Spring) 17: 494-503.