Differential associations of cortical and subcortical cerebral atrophy with retinal vascular signs in patients with acute stroke

Stroke

Volumn 41, Issue 10, 2010, Pages 2143-2150

  Baker, Michelle L ^a   Wang, Jie Jin ^a,b   Liew, Gerald ^b   Hand, Peter J ^a   De Silva, Deidre A ^c   Lindley, Richard I ^d   Mitchell, Paul ^b   Wong, Meng Cheong ^e   Rochtchina, Elena ^b   Wong, Tien Y ^a,f   Wardlaw, Joanna M ^g   Hankey, Graeme J ^h  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

^d WESTMEAD HOSPITAL   (Australia)

^e National Medical Research Council   (Singapore)

^f NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^g UNIVERSITY OF EDINBURGH   (United Kingdom)

^h UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

blood brain barrier; cerebral atrophy; cortical atrophy; retinal vascular signs; subcortical atrophy

Indexed keywords

ACUTE DISEASE; ADULT; AGED; ARTERIOLAR LIGHT REFLEX; ARTERIOLE; ARTERY DIAMETER; ARTICLE; AUSTRALIA; BRAIN ATROPHY; BRAIN CORTEX ATROPHY; BRAIN SUBCORTICAL ATROPHY; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; EYE PHOTOGRAPHY; FEMALE; HOSPITAL PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROSPECTIVE STUDY; REFLEX; RETINA ARTERY OCCLUSION; RETINA EXAMINATION; RETINA VEIN; RETINOPATHY; RISK FACTOR; SINGAPORE; STROKE; VEIN DIAMETER; ATROPHY; BRAIN CORTEX; CEREBROVASCULAR ACCIDENT; PATHOLOGY; RADIOGRAPHY; RETINA; RETINA BLOOD VESSEL; STATISTICAL MODEL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ATROPHY; AUSTRALIA; CEREBRAL CORTEX; FEMALE; HUMANS; LOGISTIC MODELS; MAGNETIC RESONANCE IMAGING; MALE; RETINA; RETINAL VESSELS; RISK FACTORS; SINGAPORE; STROKE;

EID: 77957974910     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.110.594317     Document Type: Article

References (45)

1. Whitwell JL, Jack CR Jr, Parisi JE, Knopman DS, Boeve BF, Petersen RC, Ferman TJ, Dickson DW, Josephs KA. Rates of cerebral atrophy differ in different degenerative pathologies. Brain. 2007;130:1148-1158.
2. Fox NC, Schott JM. Imaging cerebral atrophy: normal ageing to Alzheimer's disease. Lancet. 2004;363:392-394.
3. Garcia-Valdecasas-Campelo E, Gonzalez-Reimers E, Santolaria-Fernandez F, De La Vega-Prieto MJ, Milena-Abril A, Sanchez-Perez MJ, Martinez-Riera A, Rodriguez-Rodriguez E. Brain atrophy in alcoholics: relationship with alcohol intake; liver disease; nutritional status, and inflammation. Alcohol Alcohol. 2007;42:533-538.
4. Prins ND, van Dijk EJ, den Heijer T, Vermeer SE, Jolles J, Koudstaal PJ, Hofman A, Breteler MM. Cerebral small-vessel disease and decline in information processing speed, executive function and memory. Brain. 2005;128:2034-2041.
5. O'Sullivan M, Jouvent E, Saemann PG, Mangin JF, Viswanathan A, Gschwendtner A, Bracoud L, Pachai C, Chabriat H, Dichgans M. Measurement of brain atrophy in subcortical vascular disease: a comparison of different approaches and the impact of ischaemic lesions. Neuroimage. 2008;43:312-320.
6. Mungas D, Jagust WJ, Reed BR, Kramer JH, Weiner MW, Schuff N, Norman D, Mack WJ, Willis L, Chui HC. MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease. Neurology. 2001;57:2229-2235.
7. Moody DM, Brown WR, Challa VR, Ghazi-Birry HS, Reboussin DM. Cerebral microvascular alterations in aging, leukoaraiosis, and Alzheimer's disease. Ann N Y Acad Sci. 1997;826:103-116.
8. Longstreth WT Jr, Arnold AM, Manolio TA, Burke GL, Bryan N, Jungreis CA, O'Leary D, Enright PL, Fried L. Clinical correlates of ventricular and sulcal size on cranial magnetic resonance imaging of 3301 elderly People. The Cardiovascular Health Study Collaborative Research Group. Neuroepidemiology. 2000;19:30-42.
9. Strassburger TL, Lee HC, Daly EM, Szczepanik J, Krasuski JS, Mentis MJ, Salerno JA, DeCarli C, Schapiro MB, Alexander GE. Interactive effects of age and hypertension on volumes of brain structures. Stroke. 1997;28:1410-1417.
10. Swan GE, DeCarli C, Miller BL, Reed T, Wolf PA, Jack LM, Carmelli D. Association of midlife blood pressure to late-life cognitive decline and brain morphology. Neurology. 1998;51:986-993.
11. Perros P, Deary IJ, Sellar RJ, Best JJ, Frier BM. Brain Abnormalities Demonstrated by magnetic resonance imaging in adult IDDM patients with and without a history of recurrent severe hypoglycemia. Diabetes Care. 1997;20:1013-1018.
12. Araki Y, Nomura M, Tanaka H, Yamamoto H, Yamamoto T, Tsukaguchi I, Nakamura H. MRI of the brain in diabetes mellitus. Neuroradiology. 1994;36:101-103.
13. Thompson CS, Hakim AM. Living beyond our physiological means: small vessel disease of the brain is an expression of a systemic failure in arteriolar function: a unifying hypothesis. Stroke. 2009;40:e322-e330.
14. Patton N, Aslam T, Macgillivray T, Pattie A, Deary IJ, Dhillon B. Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures. J Anat. 2005;206:319-348.
15. Baker ML, Hand PJ, Wang JJ, Wong TY. Retinal signs and stroke: revisiting the link between the eye and brain. Stroke. 2008;39:1371-1379.
16. Wong TY, Mosley TH Jr, Klein R, Klein BE, Sharrett AR, Couper DJ, Hubbard LD. Retinal microvascular changes and MRI signs of cerebral atrophy in healthy, middle-aged people. Neurology. 2003;61:806-811.
17. Lindley RI. Retinal microvascular signs: a key to understanding the underlying pathophysiology of different stroke subtypes? Int J Stroke. 2008;3:297-305.
18. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE III. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24:35-41.
19. Images Analysis Schema, Guidelines and Software. 2010. Available at: www.sbirc.ed.ac.uk/imageanalysis.html#normbrain. Accessed June 21, 2010.
20. Wahlund LO, Agartz I, Almqvist O, Basun H, Forssell L, Saaf J, Wetterberg L. The brain in healthy aged individuals: MR imaging. Radiology. 1990;174:675-679.
21. Farrell C, Chappell F, Armitage PA, Keston P, Maclullich A, Shenkin S, Wardlaw JM. Development and initial testing of normal reference MR images for the brain at ages 65-70 and 75-80 years. Eur Radiol. 2009; 19:177-183.
22. Diabetic Retinopathy Study. Report Number 6. Design, methods, and baseline results. Report number 7. A modification of the Airlie House Classification of Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 1981; 21:1-226.
23. Wong TY, Klein R, Couper DJ, Cooper LS, Shahar E, Hubbard LD, Wofford MR, Sharrett AR. Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study. Lancet. 2001;358:1134-1140.
24. Mitchell P, Wang JJ, Wong TY, Smith W, Klein R, Leeder SR. Retinal microvascular signs and risk of stroke and stroke mortality. Neurology. 2005;65:1005-1009.
25. Knudtson MD, Lee KE, Hubbard LD, Wong TY, Klein R, Klein BE. Revised formulas for summarizing retinal vessel diameters. Curr Eye Res. 2003;27:143-149.
26. Schmidtke K, Hull M. Cerebral small vessel disease: how does it progress? J Neurol Sci. 2005;229-230:13-20.
27. Ashton N, Peltier S, Garner A. Experimental hypertensive retinopathy in the monkey. Trans Ophthalmol Soc U K. 1969;88:167-186.
28. Greenberg SM. Cerebral amyloid angiopathy and vessel dysfunction. Cerebrovasc Dis. 2002;13(suppl 2):42-47.
29. Farrall AJ, Wardlaw JM. Blood-brain barrier: ageing and microvascular disease-systematic review and meta-analysis. Neurobiol Aging. 2009; 30:337-352.
30. Yamamoto Y, Ihara M, Tham C, Low RW, Slade JY, Moss T, Oakley AE, Polvikoski T, Kalaria RN. Neuropathological correlates of temporal pole white matter hyperintensities in CADASIL. Stroke. 2009;40: 2004-2011.
31. Tso MO, Jampol LM. Pathophysiology of hypertensive retinopathy. Ophthalmology. 1982;89:1132-1145.
32. Doubal FN, Dhillon B, Dennis MS, Wardlaw JM. Retinopathy in ische-mic stroke subtypes. Stroke. 2009;40:389-393.
33. Wakai S, Nagai M. Histological verification of microaneurysms as a cause of cerebral haemorrhage in surgical specimens. J Neurol Neurosurg Psychiatry. 1989;52:595-599.
34. Wardlaw JM, Sandercock PA, Dennis MS, Starr J. Is breakdown of the blood- brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia? Stroke. 2003;34:806-812.
35. Fuster V, Bansilal S. Promoting cardiovascular and cerebrovascular health. Stroke. 41:1079-1083.
36. Querfurth HW, LaFerla FM. Alzheimer's disease. N Engl J Med. 362: 329-344.
37. Ikram MK, De Jong FJ, Van Dijk EJ, Prins ND, Hofman A, Breteler MM, De Jong PT. Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan Study. Brain. 2006;129:182-188. (Pubitemid 43063769)
38. Cheung N, Islam FM, Jacobs DR Jr, Sharrett AR, Klein R, Polak JF, Cotch MF, Klein BE, Ouyang P, Wong TY. Arterial compliance and retinal vascular caliber in cerebrovascular disease. Ann Neurol. 2007;62: 618-624.
39. McGeechan K, Liew G, Macaskill P, Irwig L, Klein R, Klein BE, Wang JJ, Mitchell P, Vingerling JR, de Jong PT, Witteman JC, Breteler MM, Shaw J, Zimmet P, Wong TY. Prediction of incident stroke events based on retinal vessel caliber: a systematic review and individual-participant meta-analysis. Am J Epidemiol. 2009;170:1323-1332.
40. Ikram MK, de Jong FJ, Bos MJ, Vingerling JR, Hofman A, Koudstaal PJ, de Jong PT, Breteler MM. Retinal vessel diameters and risk of stroke: the Rotterdam Study. Neurology. 2006;66:1339-1343. (Pubitemid 43739641)
41. Wong TY, Islam FM, Klein R, Klein BE, Cotch MF, Castro C, Sharrett AR, Shahar E. Retinal vascular caliber, cardiovascular risk factors, and inflammation: the Multi-Ethnic Study of Atherosclerosis (MESA). Invest Ophthalmol Vis Sci. 2006;47:2341-2350.
42. Liew G, Wang JJ, Mitchell P, Wong TY. Retinal vascular imaging: a new tool in microvascular disease research. Circ Cardiovasc Imaging. 2008; 1:156-161.
43. Kimchi EY, Kajdasz S, Bacskai BJ, Hyman BT. Analysis of cerebral amyloid angiopathy in a transgenic mouse model of Alzheimer disease using in vivo multiphoton microscopy. J Neuropathol Exp Neurol. 2001; 60:274-279.
44. Lindley RI, Wang JJ, Wong MC, Mitchell P, Liew G, Hand P, Wardlaw J, De Silva DA, Baker M, Rochtchina E, Chen C, Hankey GJ, Chang HM, Fung VS, Gomes L, Wong TY. Retinal microvasculature in acute lacunar stroke: a cross-sectional study. Lancet Neurol. 2009;8:628-634.
45. Hoggard N. Re: Development and initial testing of normal reference MR images for the brain at ages 65-70 and 75-80 years: does assessing brain atrophy on an individual patient basis need correction to peak brain volume or a surrogate? Eur Radiol. 2009;19:1025; author reply 1026.