Azathioprine-induced liver injury in a patient with multiple autoimmune syndrome

Journal of Dermatological Treatment

Volumn 21, Issue 6, 2010, Pages 357-360

  Okan, Gokhan ^a   Vural, Pervin ^b   Peker, Onder ^c   Colakoglu, Emel ^d   Saruc, Murat ^e  

^a Medical Park Bahcelievler Hospital   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c ACIBADEM HOSPITAL   (Turkey)

^d Acibadem Bakirkoy Hospital   (Turkey)

^e ACIBADEM UNIVERSITY   (Turkey)

Author keywords

Alopecia areata; Antioxidants; Azathioprine; Ulcerative colitis; Vitiligo

Indexed keywords

ALKALINE PHOSPHATASE; AZATHIOPRINE; CORTICOSTEROID; DITHRANOL; GAMMA GLUTAMYLTRANSFERASE; MESALAZINE; PREDNISONE; THIOPURINE METHYLTRANSFERASE;

ABDOMINAL PAIN; ADULT; ALOPECIA AREATA; ARTICLE; AUTOIMMUNE DISEASE; BLOODY DIARRHEA; CASE REPORT; COLONOSCOPY; DEPIGMENTATION; DIARRHEA; DRUG HYPERSENSITIVITY; DRUG WITHDRAWAL; DYSPEPSIA; EPISCLERITIS; EYE DISCOMFORT; GENOTYPE; HAIR LOSS; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER INJURY; MALE; NAUSEA AND VOMITING; PRIORITY JOURNAL; RECURRENT DISEASE; TENESMUS; ULCERATIVE COLITIS; VITILIGO; WEIGHT REDUCTION;

ADULT; AUTOIMMUNE DISEASES; AZATHIOPRINE; COLITIS, ULCERATIVE; DRUG-INDUCED LIVER INJURY; GLUCOCORTICOIDS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; PREDNISONE; SYNDROME;

EID: 77957955691     PISSN: 09546634     EISSN: 14711753     Source Type: Journal    
DOI: 10.3109/09546630903410174     Document Type: Article

References (16)

1. Katsinelos P, Kountouras J, Paroutoglou G, Zavos C. Alope-cia areata, primary sclerosing cholangitis and ulcerative colitis: An autoimmunity and apoptosis as common links? Dig Dis Sci. 2007;52(5):1288-1292.
2. Shih DQ, Targan SR. Immunopathogenesis of inflammatory bowel disease. World J Gastroenterol. 2008;14(3):390-400.
3. Humbert P, Dupond JL. The multiple autoimmune syn-dromes. BrJDermatol. 1997;136:468-469.
4. Snook JA, de Silva HJ, Jewell DP. The association of auto-immune disorders with inflammatory bowel disease. Q J Med. 1989;72(269):835-840.
5. Namazi MR. Neurogenic dysregulation, oxidative stress, auto-immunity and melanocytorrhagy in vitiligo: Can they be interconnected? Pigment Cell Res. 2007;20(5):360-363.
6. Khan R, Satyam A, Gupta S, Sharma VK, Sharma A. Circu-latory levels of antioxidants and lipid peroxidation in Indian patients with generalized and localized vitiligo. Arch Dermatol Res. 2009;301(10):731-737.
7. DellAnna ML, Mastofrancesco A, Sala R, Venturini M, Ottaviani M, Vidolin AP, et al. Antioxidants and narrow band-UVB in the treatment of vitiligo: A double-blind placebo controlled trial. Clin Exp Dermatol. 2007;32(6): 631-636.
8. Salmon JF, Wright JP, Murray AD. Ocular inflammation in Crohn's disease. Ophthalmology. 1991;98:480-484.
9. Rashidi T, Mahd AA. Treatment ofpersistent alopecia areata with sulfasalazine. Int J Dermatol. 2008;47(8):850-852.
10. Ardizzone S, Bianchi Porro G. Comparative tolerability of therapies for ulcerative colitis. Drug Saf. 2002;25:561-582.
11. Etchever MJ, Aceituno M, Sans M. Are we giving azathioprine too late? The case for early immunomodulation in inflamma-tory bowel disease. World J Gastroenterol. 2008;14(36): 5512-5518.
12. Bastida G, Nos P, Aguas M, Beltran B, Rubin A, Dasi F, et al. Incidence, risk factors and clinical course of thiopurine-induced liver injury in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2005;22(9):775-782.
13. Masaaki K, Masatoshi S, Nihal SA. Antioxidant system and erythrocyte-life-span in mammals. Comp Biochem Physiol. 1993;106B:477-487.
14. Baert F, Vermeire S, Noman M, Van Assche G, D'Haens G, Rutgeerts P. Management of ulcerative colitis and Crohn's disease. Acta Clin Belg. 2004;59(5):304-314. (Pubitemid 40029490)
15. Domenech E. Inflammatory bowel disease: Current therapeutic options. Digestion. 2006;73(suppl 1):67-76. Epub 2006 Feb 8.
16. Regueiro M, Valentine J, Plevy S, Fleisher MR, Lichtenstein GR. Infliximab for treatment of pyoderma gang-renosum associated with inflammatory bowel disease. Am J Gastroenterol. 2003;98:1821-1826.