Genes, brain, and behavior: Development gone awry in autism? A report on the 23rd annual international symposium of the center for the study of gene structure and function

Annals of the New York Academy of Sciences

Volumn 1205, Issue SUPPL.1, 2010, Pages E21-E36

  Lewis, Michael J ^a   Dictenberg, Jason B ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Asperger's syndrome; Autism spectrum disorder (ASD); Axon; Brain circuit; Connectome; Dendrite; Early start denver model (esdm); Endophenotype; Epilepsy; Fragile X syndrome (FXS); Joint attention; Mental retardation; Microcephaly with seizures (MCSZ); Mirror neurons; Neuron; Specific language impairment (SLI); Synapse

Indexed keywords

ARTICLE; ASPERGER SYNDROME; ATTENTION; AUTISM; BEHAVIORAL SCIENCE; FRAGILE X SYNDROME; GENE EXPRESSION; GENE FUNCTION; GENE STRUCTURE; HUMAN; LANGUAGE DISABILITY; MEDICAL RESEARCH; MENTAL DEFICIENCY; MICROCEPHALY; MIRROR NEURON; NEUROBIOLOGY; NEUROPSYCHOLOGY; NEUROSCIENCE; PHENOTYPE; SYMPTOMATOLOGY; SYNAPSE; ANIMAL; BRAIN; CHILD; CHILD BEHAVIOR; CHILD PARENT RELATION; CONFERENCE PAPER; EARLY DIAGNOSIS; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY;

BIOLOGICAL MARKER;

ANIMALS; BIOLOGICAL MARKERS; BRAIN; CHILD; CHILD BEHAVIOR; CHILD DEVELOPMENT DISORDERS, PERVASIVE; EARLY DIAGNOSIS; GENE EXPRESSION; HUMANS; NEURONS; PARENT-CHILD RELATIONS; PHENOTYPE; SYNAPSES;

EID: 77957954244     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2010.05723.x     Document Type: Article

References (42)

1. Purpura, D.P. 1974. Dendritic spine "dysgenesis" andmental retardation. Science 186: 1126-1128.
2. Marin-Padilla, M. 1972. Structural abnormalities of the cerebral cortex in human chromosomal aberrations: a Golgi study. Brain Res. 44: 625-629.
3. Ferrer, I. & F. Gullotta. 1990. Down's syndrome and Alzheimer's disease: dendritic spine counts in the hippocampus. Acta Neuropathol. 79: 680-685.
4. Alarcon, M. et al. 2008. Linkage, association, and geneexpression analyses identify CNTNAP2 as an autismsusceptibility gene. Am. J. Hum. Genet. 82: 150-159.
5. Vernes, S.C. et al. 2008. A functional genetic link between distinct developmental language disorders. N. Engl. J. Med. 359: 2337-2345.
6. Jamain, S. et al. 2003. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat. Genet. 34: 27-29.
7. Laumonnier, F. et al. 2004. X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family. Am. J. Hum. Genet. 74: 552-557.
8. Dapretto, M. et al. 2006. Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat. Neurosci. 9: 28-30.
9. Shen, J. et al. 2010.Mutations in PNKP cause microcephaly, seizures and defects in DNA repair. Nat. Genet. 42: 245-249.
10. Morrow, E.M. et al. 2008. Identifying autism loci and genes by tracing recent shared ancestry. Science 321: 218-223.
11. Walsh, C.A., E.M. Morrow & J.L. Rubenstein. 2008. Autism and brain development. Cell 135: 396-400.
12. Geschwind, D.H. 2008. Autism:many genes, common pathways? Cell 135: 391-395.
13. Cornish, K., J. Turk & R.Hagerman. 2008. The fragile X continuum: new advances and perspectives. J. Intellect. Disabil. Res. 52: 469-482.
14. Bassell, G.J. & S.T. Warren. 2008. Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. Neuron. 60: 201-214.
15. Dictenberg, J.B., S.A. Swanger, L.N. Antar, et al. 2008. A direct role for FMRP in activity-dependent dendriticmRNA transport links filopodial-spine morphogenesis to fragile X syndrome. Dev. Cell. 14: 926-939.
16. Huber, K.M., S.M.Gallagher, S.T. Warren & M.F. Bear. 2002. Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proc. Natl. Acad. Sci. USA 99: 7746-7750.
17. Ching, M.S. et al. 2010. Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders. Am. J.Med. Genet. B Neuropsychiatr. Genet. 153B: 937-947.
18. Muddashetty, R.S., S. Kelic, C. Gross, et al. 2007. Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95mRNAs at synapses in a mouse model of fragile X syndrome. J. Neurosci. 27: 5338-5348.
19. Hubel, D.H., T.N. Wiesel & S. LeVay. 1977. Plasticity of ocular dominance columns in monkey striate cortex. Philos. Trans. R. Soc. Lond. B Biol. Sci. 278: 377-409.
20. Wu, G., R. Malinow & H.T. Cline. 1996. Maturation of a central glutamatergic synapse. Science 274: 972-976.
21. Bestman, J.E. & H.T. Cline. 2008. The RNA binding protein CPEB regulates dendrite morphogenesis and neuronal circuit assembly in vivo. Proc. Natl.Acad. Sci. USA105: 20494-20499.
22. Misgeld, T. et al. 2002. Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase. Neuron 36: 635-648.
23. Sanes, J.R. & J.W. Lichtman. 2001. Induction, assembly, maturation and maintenance of a postsynaptic apparatus. Nat. Rev. Neurosci. 2: 791-805.
24. Livet, J. et al. 2007. Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system. Nature 450: 56-62.
25. Draft, R.W. & J.W. Lichtman. 2009. It's lonely at the top: winning climbing fibers ascend dendrites solo. Neuron 63: 6-8.
26. Lu, J., J.C. Tapia, O.L. White & J.W. Lichtman 2009. The interscutularis muscle connectome. PLoS Biol. 7: e32.
27. Kogan, M.D. et al. 2008. A national profile of the health care experiences and family impact of autism spectrum disorder among children in the United States, 2005-2006. Pediatrics 122: e1149-1158.
28. McCleery, J.P., E. Allman, L.J. Carver & K.R. Dobkins. 2007. Abnormal magnocellular pathway visual processing in infants at risk for autism. Biol. Psychiatry 62: 1007-1014.
29. McCleery, J.P., N. Akshoomoff, K.R. Dobkins & L.J. Carver. 2009.Atypical face versus object processing and hemispheric asymmetries in 10-month-old infants at risk for autism. Biol. Psychiatry 66: 950-957.
30. Meltzoff, A.N., P.K. Kuhl, J. Movellan & T.J. Sejnowski. 2009. Foundations for a new science of learning. Science 325: 284-288.
31. Dawson, G. et al. 2010. Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model. Pediatrics 125: e17-23.
32. Pierce, K., F. Haist, F. Sedaghat & E. Courchesne. 2004. The brain response to personally familiar faces in autism: findings of fusiform activity and beyond. Brain 127: 2703-2716.
33. Wang, A.T., S.S. Lee, M. Sigman &M. Dapretto. 2007. Reading affect in the face and voice: neural correlates of interpreting communicative intent in children and adolescents with autism spectrum disorders. Arch. Gen. Psychiatry 64: 698-708.
34. Kjelgaard, M.M. & H. Tager-Flusberg. 2001.An investigation of language impairment in autism: implications for genetic subgroups. Lang. Cogn. Process. 16: 287-308.
35. Roberts, J.A., M.L. Rice & H. Tager-Flusberg. 2004. Tense marking in children with autism. Applied Psycholinguistics 25: 429-448.
36. Herbert, M.R. et al. 2002. Abnormal asymmetry in language association cortex in autism. Ann. Neurol. 52: 588-596.
37. De Fosse, L. et al. 2004. Language-association cortex asymmetry in autism and specific language impairment. Ann. Neurol. 56: 757-766.
38. Lindgren, K.A., S.E. Folstein, J.B. Tomblin & H. Tager-Flusberg. 2009. Language and reading abilities of children with autism spectrum disorders and specific language impairment and their first-degree relatives. Autism Res. 2: 22-38.
39. Siller, M. & M. Sigman. 2008.Modeling longitudinal change in the language abilities of children with autism: parent behaviors and child characteristics as predictors of change. Dev. Psychol. 44: 1691-1704.
40. 2007. Prevalence of autism spectrumdisorders-autism and developmental disabilities monitoring network, 14 sites, United States, 2002. MMWR Surveill. Summ. 56: 12-28.
41. Van Naarden Braun, K. et al. 2007. Evaluation of amethodology for a collaborative multiple source surveillance network for autism spectrum disorders-Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2002. MMWR Surveill. Summ. 56: 29-40.
42. 2009. Prevalence of autism spectrumdisorders-Autism and Developmental Disabilities Monitoring Network, United States, 2006. MMWR Surveill. Summ. 58: 1-20.