The presence of isolated tumor cells and micrometastases in the intrathoracic lymph nodes of patients with lung cancer is not associated with decreased survival

Human Pathology

Volumn 41, Issue 11, 2010, Pages 1536-1543

  Marchevsky, Alberto M ^a   Gupta, Ruta ^a   Kusuanco, Donato ^a   Mirocha, James ^a   McKenna Jr , Robert J ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Evidence based pathology; Lung cancer; Micrometastases; Prognosis; Statistical analysis

Indexed keywords

CYTOKERATIN AE1; CYTOKERATIN AE3;

ADULT; AGED; ARTICLE; CANCER STAGING; DISEASE ASSOCIATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRATHORACIC LYMPH NODE; LUNG NON SMALL CELL CANCER; LYMPH NODE; MAJOR CLINICAL STUDY; MALE; MICROMETASTASIS; PROGNOSIS; SURVIVAL; TUMOR CELL; EPIDEMIOLOGY; KAPLAN MEIER METHOD; LUNG TUMOR; LYMPH NODE METASTASIS; META ANALYSIS; MIDDLE AGED; MORTALITY; NON SMALL CELL LUNG CANCER; PATHOLOGY; SECONDARY; SURVIVAL RATE; THORAX; UNITED STATES; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CALIFORNIA; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; HUMANS; KAPLAN-MEIERS ESTIMATE; LUNG NEOPLASMS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; PROGNOSIS; SURVIVAL RATE; THORAX; KAPLAN-MEIER ESTIMATE;

EID: 77957944451     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2010.04.006     Document Type: Article

References (31)

1. Martini N., Bains M.S., and Burt M.E. Incidence of local recurrence and second primary tumors in resected stage I lung cancer J Thorac Cardiovasc Surg 109 1995 120 129
2. Nesbitt J.C., Putnam J.B. Jr, Walsh G.L., Roth J.A., and Mountain C.F. Survival in early-stage non-small cell lung cancer Ann Thorac Surg 60 1995 466 472
3. Xi L., Lyons-Weiler J., and Coello M.C. Prediction of lymph node metastasis by analysis of gene expression profiles in primary lung adenocarcinomas Clin Cancer Res 11 2005 4128 4135
4. Okumura Y., Tanaka F., and Yoneda K. Circulating tumor cells in pulmonary venous blood of primary lung cancer patients Ann Thorac Surg 87 2009 1669 1675
5. Osaki T., Oyama T., and Gu C.D. Prognostic impact of micrometastatic tumor cells in the lymph nodes and bone marrow of patients with completely resected stage I non-small-cell lung cancer J Clin Oncol 20 2002 2930 2936 (Pubitemid 34728886)
6. Brunsvig P.F., Flatmark K., and Aamdal S. Bone marrow micrometastases in advanced stage non-small cell lung carcinoma patients Lung Cancer 61 2008 170 176
7. Bell D.W., Lynch T.J., and Haserlat S.M. Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials J Clin Oncol 23 2005 8081 8092
8. Riely G.J., Marks J., and Pao W. KRAS mutations in non-small cell lung cancer Proc Am Thorac Soc 6 2009 201 205
9. Nicholson A.G., Graham A.N., and Pezzella F. Does the use of immunohistochemistry to identify micrometastases provide useful information in the staging of node-negative non-small cell lung carcinomas? Lung Cancer 18 1997 231 240
10. Marchevsky A.M., Qiao J.H., Krajisnik S., Mirocha J.M., and McKenna R.J. The prognostic significance of intranodal isolated tumor cells and micrometastases in patients with non-small cell carcinoma of the lung J Thorac Cardiovasc Surg 126 2003 551 557
11. Rena O., Carsana L., and Cristina S. Lymph node isolated tumor cells and micrometastases in pathological stage I non-small cell lung cancer: prognostic significance Eur J Cardiothorac Surg 32 2007 863 867
12. Salerno C.T., Frizelle S., and Niehans G.A. Detection of occult micrometastases in non-small cell lung carcinoma by reverse transcriptase- polymerase chain reaction Chest 113 1998 1526 1532
13. Mineo T.C., Ambrogi V., Pompeo E., and Baldi A. Immunohistochemistry- detected microscopic tumor spread affects outcome in en-bloc resection for T3-chest wall lung cancer Eur J Cardiothorac Surg 31 2007 1120 1124
14. Goldstein N.S., Mani A., Chmielewski G., Welsh R., and Pursel S. Immunohistochemically detected micrometastases in peribronchial and mediastinal lymph nodes from patients with T1, N0, M0 pulmonary adenocarcinomas Am J Surg Pathol 24 2000 274 279
15. Gu C.D., Osaki T., and Oyama T. Detection of micrometastatic tumor cells in pN0 lymph nodes of patients with completely resected nonsmall cell lung cancer: impact on recurrence and Survival Ann Surg 235 2002 133 139 (Pubitemid 34062409)
16. Ishiwa N., Ogawa N., and Shoji A. Correlation between lymph node micrometastasis and histologic classification of small lung adenocarcinomas, in considering the indication of limited surgery Lung Cancer 39 2003 159 164
17. Hashimoto T., Kobayashi Y., and Ishikawa Y. Prognostic value of genetically diagnosed lymph node micrometastasis in non-small cell lung carcinoma cases Cancer Res 60 2000 6472 6478
18. Maeda J., Inoue M., and Okumura M. Detection of occult tumor cells in lymph nodes from non-small cell lung cancer patients using reverse transcription-polymerase chain reaction for carcinoembryonic antigen mRNA with the evaluation of its sensitivity Lung Cancer 52 2006 235 240
19. Maruyama R., Sugio K., and Mitsudomi T. Relationship between early recurrence and micrometastases in the lymph nodes of patients with stage I non-small-cell lung cancer J Thorac Cardiovasc Surg 114 1997 535 543
20. Melfi F.M., Lucchi M., and Davini F. Intraoperative sentinel lymph node mapping in stage I non-small cell lung cancer: detection of micrometastases by polymerase chain reaction Eur J Cardiothorac Surg 34 2008 181 186
21. Passlick B., Kubuschock B., and Sienel W. Mediastinal lymphadenectomy in non-small cell lung cancer: effectiveness in patients with or without nodal micrometastases-results of a preliminary study Eur J Cardiothorac Surg 21 2002 520 526
22. Wu J., Ohta Y., and Minato H. Nodal occult metastasis in patients with peripheral lung adenocarcinoma of 2.0 cm or less in diameter Ann Thorac Surg 71 2001 1772 1777 [discussion 7-8]
23. Izbicki J.R., Passlick B., and Hosch S.B. Mode of spread in the early phase of lymphatic metastasis in non-small-cell lung cancer: significance of nodal micrometastasis J Thorac Cardiovasc Surg 112 1996 623 630
24. Nosotti M., Falleni M., and Palleschi A. Quantitative real-time polymerase chain reaction detection of lymph node lung cancer micrometastasis using carcinoembryonic antigen marker Chest 128 2005 1539 1544
25. Benlloch S., Galbis-Caravajal J.M., and Alenda C. Expression of molecular markers in mediastinal nodes from resected stage I non-small-cell lung cancer (NSCLC): prognostic impact and potential role as markers of occult micrometastases Ann Oncol 20 2009 91 97
26. American Joint Committee on Cancer, AJCC Cancer Staging Manual 7th ed 2002 Springer New York
27. Gupta R., Dastane A.M., McKenna R. Jr, and Marchevsky A.M. The predictive value of epidermal growth factor receptor tests in patients with pulmonary adenocarcinoma: review of current "best evidence" with meta-analysis Hum Pathol 40 2009 356 365
28. Gupta R., Marchevsky A.M., and McKenna R.J. Evidence-based pathology and the pathologic evaluation of thymomas: transcapsular invasion is not a significant prognostic feature Arch Pathol Lab Med 132 2008 926 930
29. Marchevsky A.M., Gupta R., and McKenna R.J. Evidence-based pathology and the pathologic evaluation of thymomas: the World Health Organization classification can be simplified into only 3 categories other than thymic carcinoma Cancer 112 2008 2780 2788
30. Marchevsky A.M., and Wick M.R. Evidence-based medicine, medical decision analysis and pathology Hum Pathol 35 2004 1179 1188
31. Marchevsky A.M. Evidence-based medicine and pathology: an introduction. Semin Diagn Pathol 22 2005 105 115