Lymph node isolated tumor cells and micrometastases in pathological stage I non-small cell lung cancer: prognostic significance

European Journal of Cardio-thoracic Surgery

Volumn 32, Issue 6, 2007, Pages 863-867

  Rena, Ottavio ^a   Carsana, Luca ^a   Cristina, Silvia ^a   Papalia, Esther ^a   Massera, Fabio ^a   Errico, Luca ^a   Bozzola, Cristina ^a   Casadio, Caterina ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Lung cancer; Lymph nodes; Metastasis; Staging; Survival

Indexed keywords

EOSIN; HEMATOXYLIN;

ADULT; ARTICLE; CANCER PATIENT; CANCER RECURRENCE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CELL PROLIFERATION; CONSERVATIVE TREATMENT; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL CARCINOMA; LUNG ADENOCARCINOMA; LUNG BIOPSY; LUNG NON SMALL CELL CANCER; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MICROMETASTASIS; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; SQUAMOUS CELL CARCINOMA; STATISTICAL SIGNIFICANCE; TUMOR BIOPSY;

ADULT; AGED; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; FOLLOW-UP STUDIES; HUMANS; LUNG NEOPLASMS; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; SURVIVAL ANALYSIS;

EID: 35748959610     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2007.09.014     Document Type: Article

References (17)

1. Naruke T., Goya T., Tsuchiya R., and Suemann K. Prognosis and survival in resected lung carcinoma based on the new international staging system. J Thorac Cardiovasc Surg 96 (1988) 440-447
2. Nesbitt J.C., Putnam J.B., Walsh G.L., Roth J.A., and Putnam Jr. J.B. Survival in early-stage non-small cell lung cancer. Ann Thorac Surg 60 (1995) 466-472
3. Rena O., Oliaro A., Cavallo A., Filosso P.L., Donati G., DiMarzio P., Maggi G., and Ruffini E. Stage I non-small cell lung carcinoma: really an early stage?. Eur J Cardio-thorac Surg 21 (2002) 514-519
4. Chen Z.L., Perez S., Holmes E.C., Wang H.J., Coulson W.F., Wen D.R., and Cochran A.J. Frequency and distribution of occult micrometastases in lymph nodes of patients with non-smallcell lung carcinoma. J Natl Cancer Inst 85 (1993) 493-498
5. Maruyama R., Sugio K., Mitsudomi T., Saitoh G., Ishida T., and Sugimachi K. Relationship between early recurrence and micrometastases in the lymph node of patients with stage I non-smallcell lung cancer. J Thorac Cardiovasc Surg 114 (1997) 535-543
6. Gu C.D., Osaki T., Oyama T., Inoue M., Kodate M., Dobashi K., Oka T., and Yasumoto K. Detection of micrometastatic tumor cells in pN0 lymph nodes of patients with completely resected non-smallcell lung cancer: impact on recurrence and survival. Ann Surg 235 (2002) 133-139
7. American Joint Committee on Cancer. AJCC cancer staging manual. 6th ed. (2002), Springer, New York
8. Mountain C.F. Revision in the international system for staging lung cancer. Chest 111 (1997) 1710-1717
9. Izbicki J.R., Passlick B., Hosch S.B., Kubuschock B., Schneider C., Busch C., Koenfel W.T., Thetter O., and Pantel K. Mode of spread in the early phase of lymphatic metastasis in non-small cell lung cancer: significance of nodal micrometastasis. J Thorac Cardiovasc Surg 112 (1996) 623-630
10. Nicholson A.G., Graham A.N.J., Pezzella F., Agneta G., Goldstraw P., and Pastorino U. Does the use of immunohistochemistry to identify micrometastases provide useful information in the staging of node-negative non-small cell lung carcinoma?. Lung Cancer 18 (1997) 231-240
11. Kubuschok B., Passlick B., Izbiki J.R., Thetter O., and Pantel K. Disseminated tumor cells in lymph nodes as a determinant for survival in surgically resected non-small cell lung cancer. J Clin Oncol 17 (1999) 19-24
12. Passlik B. Micrometastases in non-small cell lung cancer (NSCLC). Lung Cancer 34 (2001) S25-S29
13. Wu J., Ohta Y., Minato H., Tsunezuka Y., Oda M., Watanabe Y., and Watanabe G. Nodal occult metastasis in patients with peripheral lung adenocarcinoma of 2.0 cm or less in diameter. Ann Thorac Surg 71 (2001) 1772-1778
14. Passlick B., Kubuschock B., Sienel W., Thetter O., Pantel K., and Izbicki J.R. Mediastinal lymphadenectmoy in non-small cell lung cancer: effectiveness in patients with or without nodal micrometastases - results of a preliminary study. Eur J Cardio thorac Surg 21 (2002) 520-526
15. Osaki T., Oyama T., Gu C.D., Yamashita T., So T., Takenoyama M., Sugio K., and Yasumoto K. Prognostic impact of micrometastatatic tumor cells in the lymph nodes and bone marrow of patients with completely resected stage I non-small cell lung cancer. J Clin Oncol 13 (2002) 2930-2936
16. Marchevsky A.M., Qiao J.H., Krajisnik S., Mirocha J.M., and McKenna R.J. The prognostic significance of intranodal isolated tumor cells and micrometastases in patients with non-small cell carcinoma of the lung. J Thorac Cardiovasc Surg 126 (2003) 551-557
17. Goldstein N.S., Mani A., Chmielewski G., Welsh R., and Pursel S. Immunohistochemically detected micrometastases in peribronchial and mediastinal lymph nodes from patients with T1, N0, M0 pulmonary adenocarcinomas. Am J Surg Pathol 24 (2000) 274-279