Oral probiotic and prevention of Pseudomonas aeruginosa infections: A randomized, double-blind, placebo-controlled pilot study in intensive care unit patients

Critical Care

Volumn 12, Issue 3, 2008, Pages

  Forestier, Christiane ^a   Guelon, Dominique ^b   Cluytens, Valérie ^b   Gillart, Thierry ^b   Sirot, Jacques ^a   De Champs, Christophe ^c  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b SERVICE DE RHUMATOLOGIE   (France)

^c UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTAZIDIME; CIPROFLOXACIN; FLUCONAZOLE; IMIPENEM; OMEPRAZOLE; PLACEBO; PROBIOTIC AGENT;

ACID ASPIRATION; ADULT; AGED; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL PNEUMONIA; BACTERIUM CULTURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FRANCE; GRAM NEGATIVE INFECTION; HUMAN; INTENSIVE CARE; LACTOBACILLUS CASEI; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; PILOT STUDY; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RANDOMIZED CONTROLLED TRIAL; STRESS ULCER; ADOLESCENT; INTENSIVE CARE UNIT; MICROBIOLOGY; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; RESPIRATORY SYSTEM; RESPIRATORY TRACT INFECTION; STOMACH;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INTENSIVE CARE UNITS; LACTOBACILLUS CASEI; MALE; MIDDLE AGED; PILOT PROJECTS; PROBIOTICS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; PSEUDOMONAS INFECTIONS; RESPIRATORY SYSTEM; RESPIRATORY TRACT INFECTIONS; STOMACH;

EID: 44849142149     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc6907     Document Type: Article

References (46)

1. Bengmark S Ecological control of the gastrointestinal tract. The role of probiotic flora Gut 1998, 42:2-7. 1726957 9505873
2. Bengmark S Symbiotics to strengthen gut barrier function and reduce morbidity in critically ill patients Clin Nutr 2004, 23:441-445. 10.1016/ j.clnu.2004.01.005 15297078
3. Bert F Lambert-Zechovsky N Bacteria isolated from protected bronchopulmonary samples: Variation as a function of the previous length of stay in the recovery room Pathol Biol 1998, 46:380-384. 9769865
4. Bonten MJ Gaillard CA Hulst van der R de Leeuw PW Geest van der S Stobberingh EE Soeters PB Intermittent enteral feeding: The influence on respiratory and digestive tract colonization in mechanically ventilated intensive-care-unit patients Am J Respir Crit Care Med 1996, 154:394-399. 8756812
5. Bergmans DC Bonten MJ Gaillard CA Paling JC Geest van der S van Tiel FH Beysens AJ de Leeuw PW Stobberingh EE Prevention of ventilator-associated pneumonia by oral decontamination: A prospective, randomized, double-blind, placebo-controlled study Am J Respir Crit Care Med 2001, 164:382-388. 11500337
6. Bonten MJ Gaillard CA de Leeuw PW Stobberingh EE Role of colonization of the upper intestinal tract in the pathogenesis of ventilator-associated pneumonia Clin Infect Dis 1997, 24:309-319. 9114178
7. Bonten MJ Gaillard CA Geest van der S van Tiel FH Beysens AJ Smeets HG Stobberingh EE The role of intragastric acidity and stress ulcus prophylaxis on colonization and infection in mechanically ventilated ICU patients. A stratified, randomized, double-blind study of sucralfate versus antacids Am J Respir Crit Care Med 1995, 152:1825-1834. 8520743
8. Brun-Buisson C Legrand P Rauss A Richard C Montravers F Besbes M Meakins JL Soussy CJ Lemaire F Intestinal decontamination for control of nosocomial multiresistant gram-negative bacilli. Study of an outbreak in an intensive care unit Ann Intern Med 1989, 110:873-881. 2655521
9. de Latorre FJ Pont T Ferrer A Rossello J Palomar M Planas M Pattern of tracheal colonization during mechanical ventilation Am J Respir Crit Care Med 1995, 152:1028-1033. 7663779
10. Bonten MJ Brun-Buisson C Weinstein RA Selective decontamination of the digestive tract: To stimulate or stifle? Intensive Care Med 2003, 29:672-676. 12825560
11. Leone M Albanese J Antonini F Nguyen-Michel A Martin C Long-term (6-year) effect of selective digestive decontamination on antimicrobial resistance in intensive care, multiple-trauma patients Crit Care Med 2003, 31:2090-2095. 10.1097/01.CCM.0000079606.16776.C5 12973164
12. Stoutenbeek CP van Saene HK Miranda DR Zandstra DF The effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients Intensive Care Med 1984, 10:185-192. 10.1007/BF00259435 6470306
13. van Saene HKF Petros AJ Ramsay G Baxby D All great truths iconoclastic: selective decontamination of the digestive tract moves from heresy to level 1 truth Intensive Care Med 2003, 29:677-690. 10.1007/ s00134-003-1770-7 12687326
14. Liberati A D'Amico R Pifferi S Torri V Brazzi L Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care The Cochrane Collaboration 2006, 1:1-54.
15. Silvestri L van Saene HKF Milanese M Duri D Gregori D Gullo A Selective decontamination of the digestive tract reduces blood stream infections and mortality in critically ill patients. Systematic review of randomized, controlled trials J Hosp Infect 2007, 65:187-203. 10.1016/ j.jhin.2006.10.014 17244516
16. Stoutenbeek CP van Saene HKF Little RA Whitehead RA for the Working Group on Selective Decontamination of the Digestive Tract The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients: A multicenter randomized controlled trial Intensive Care Med 2007, 33:261-270. 10.1007/s00134-006-0455-4 17146635
17. Bonten MJ Kullberg BJ van Dalen R Girbes AR Hoepelman IM Hustinx W Meer van der JW Speelman P Stobberingh EE Verbrugh HA Verhoef J Zwaveling JH Selective digestive decontamination in patients in intensive care. The Dutch Working Group on Antibiotic Policy J Antimicrob Chemother 2000, 46:351-362. 10.1093/jac/46.3.351 10980160
18. Kollef MH Ventilator-associated pneumonia. A multivariate analysis Jama 1993, 270:1965-1970. 10.1001/jama.270.16.1965 8411554
19. Kollef MH Private attending physician status and the withdrawal of life-sustaining interventions in a medical intensive care unit population Crit Care Med 1996, 24:968-975. 10.1097/ 00003246-199606000-00016 8681600
20. Rello J Ausina V Ricart M Castella J Prats G Impact of previous antimicrobial therapy on the etiology and outcome of ventilator-associated pneumonia Chest 1993, 104:1230-1235. 10.1378/ chest.104.4.1230 8404198
21. Silvestri L van Saene HKF Thomann C Peric M Selective decontamination of the digestive tract reduces pneumonia and mortality without resistance emerging Am J Infect Control 2007, 35:354-357. 10.1016/ j.ajic.2006.07.003 17577486
22. de Jonge E Schultz MJ Spanjaard L Bossuyt PMM Vroom MB Dankert J Kesecioglu J Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: A randomised controlled trial Lancet 2003, 362:1011-1015. 10.1016/ S0140-6736(03)14409-1 14522530
23. Tenover FC Hughes JM WHO Scientific Working Group on monitoring and management of bacterial resistance to antimicrobial agents Emerg Infect Dis 1995, 1:37. 8903156
24. de Champs C Maroncle N Balestrino D Rich C Forestier C Persistence of colonization of intestinal mucosa by a probiotic strain, Lactobacillus casei subsp. rhamnosus Lcr35, after oral consumption J Clin Microbiol 2003, 41:1270-1273. 150315 12624065 10.1128/JCM.41.3.1270-1273.2003
25. Forestier C De Champs C Vatoux C Joly B Probiotic activities of Lactobacillus casei rhamnosus: In vitro adherence to intestinal cells and antimicrobial properties Res Microbiol 2001, 152:167-173. 10.1016/ S0923-2508(01)01188-3 11316370
26. Alcon A Fabregas N Torres A Hospital-acquired pneumonia: Etiologic considerations Infect Dis Clin North Am 2003, 17:679-695. 10.1016/ S0891-5520(03)00074-6 15008591
27. American Thoracic Society Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia Am J Respir Crit Care Med 2005, 171:388-416. 10.1164/ rccm.200405-644ST 15699079
28. Anderson AD McNaught CE Jain PK MacFie J Randomised clinical trial of synbiotic therapy in elective surgical patients Gut 2004, 53:241-245. 1774935 14724157 10.1136/gut.2003.024620
29. Trouillet JL Chastre J Vuagnat A Joly-Guillou ML Combaux D Dombret MC Gibert C Ventilator-associated pneumonia caused by potentially drug-resistant bacteria Am J Respir Crit Care Med 1998, 157:531-539. 9476869
30. Trouillet JL Vuagnat A Combes A Kassis N Chastre J Gibert C Pseudomonas aeruginosa ventilator-associated pneumonia: Comparison of episodes due to piperacillin-resistant versus piperacillin-susceptible organisms Clin Infect Dis 2002, 34:1047-1054. 10.1086/339488 11914992
31. Andrews P Azoulay E Antonelli M Brochard L Brun-Buisson C Dobb G Fagon JY Gerlach H Groeneveld J Mancebo J Metnitz P Nava S Pugin J Pinsky M Radermacher P Richard C Tasker R Year in review in intensive care medecine, 2005. II. Infection and sepsis, ventilator-associated pneumonia, ethics, haematology and haemostasis, ICU organisation and scoring, brain injury Intensive Care Med 2006, 32:380-390. 10.1007/ s00134-005-0060-y 16485094
32. Concato J Feinstein AR Holford TR The risk of determinating risk with multivariable models Ann Intern Med 1993, 118:201-210. 8417638
33. Harbarth S Liassine N Dharan S Herrault P Auckenthaler R Pittet D Risk factors for persistent carriage of methicillin-resistant Staphylococcus aureus Clin Infect Dis 2000, 31:1380-1385. 10.1086/317484 11096006
34. Le Gall JR Lemeshow S Saulnier F A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study Jama 1993, 270:2957-2963. 10.1001/jama.270.24.2957 8254858
35. Horan T Gaynes R Surveillance of nosocomial infections Hospital Epidemiology and Infection Control Philadelphia, PA: Lippincott Williams & Wilkins Mayhall C 3 2004, 1650-1702.
36. Sirvent JM Vidaur L Gonzalez S Castro P de Batlle J Castro A Bonet A Microscopic examination of intracellular organisms in protected bronchoalveolar mini-lavage fluid for the diagnosis of ventilator-associated pneumonia Chest 2003, 123:518-523. 10.1378/ chest.123.2.518 12576375
37. Peduzzi P Concato J Feinstein AR Holford TR Importance of events per independent variable in proportional hazards regression analysis II. accuracy and precision of regression estimates J Clin Epidemiol 1995, 12:1503-1510. 10.1016/0895-4356(95)00048-8
38. Isakow W Morrow LE Kollef MH Probiotics for preventing and treating nosocomial infections: Review of current evidence and recommandations Chest 2007, 132:286-294. 10.1378/chest.06-2156 17625089
39. Fedorak RN Madsen KL Probiotics and the management of inflammatory bowel disease Inflamm Bowel Dis 2004, 10:286-299. 10.1097/ 00054725-200405000-00018 15290926
40. Guarner F Malagelada JR Gut flora in health and disease Lancet 2003, 361:512-519. 10.1016/S0140-6736(03)12489-0 12583961
41. Kruis W Review article: Antibiotics and probiotics in inflammatory bowel disease Aliment Pharmacol Ther 2004, 20(suppl 4):75-78. 10.1111/ j.1365-2036.2004.02051.x 15352898
42. Reid G Jass J Sebulsky MT McCormick JK Potential uses of probiotics in clinical practice Clin Microbiol Rev 2003, 16:658-672. 207122 14557292 10.1128/CMR.16.4.658-672.2003
43. Sartor RB Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: Antibiotics, probiotics, and prebiotics Gastroenterology 2004, 126:1620-1633. 10.1053/j.gastro.2004.03.024 15168372
44. Spindler-Vesel A Bengmark S Vovk I Cerovic O Kompan L Synbiotics, prebiotics, Glutamine, or peptide in early enteral nutrition: A randomized study in trauma patients J Parenter Enteral Nutr 2007, 31:119-126. 10.1177/0148607107031002119
45. Ishibashi N Yamazaki S Probiotics and safety Am J Clin Nutr 2001, 73:465S-470S. 11157359
46. Boyle RJ Robins-Browne RM Tang ML Probiotic use in clinical practice: what are the risks? Am J Clin Nutr 2006, 83:1256-1264. quiz 1446-1257. 16762934