Ferritin concentrations in synovial fluid are higher in osteoarthritis patients with HFE gene mutations (C282Y or H63D)

Scandinavian Journal of Rheumatology

Volumn 39, Issue 5, 2010, Pages 413-420

  Carroll, G J ^a,c   Sharma, G ^b   Upadhyay, A ^b   Jazayeri, J A ^b  

^a UNIVERSITY OF NOTRE DAME   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c ArthroCare (Australasia Pty Ltd)   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; CYTOKINE; FERRITIN; HFE PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; INTERSTITIAL COLLAGENASE; LEUKEMIA INHIBITORY FACTOR; MATRIX METALLOPROTEINASE; ONCOSTATIN M; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR ALPHA; HFE PROTEIN, HUMAN; HLA ANTIGEN CLASS 1; LIF PROTEIN, HUMAN; MEMBRANE PROTEIN;

ARTHROCENTESIS; ARTICLE; CHRONIC ARTHRITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE MUTATION; GENOTYPE; HETEROZYGOTE; HUMAN; IMMUNOPATHOGENESIS; KNEE OSTEOARTHRITIS; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; PHYSICIAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; ADULT; AGED; BLOOD; COMPARATIVE STUDY; GENETICS; HOMOZYGOTE; METABOLISM; MIDDLE AGED; MUTATION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CYTOKINES; FEMALE; FERRITINS; GENOTYPE; HETEROZYGOTE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HOMOZYGOTE; HUMANS; LEUKEMIA INHIBITORY FACTOR; MALE; MATRIX METALLOPROTEINASES; MEMBRANE PROTEINS; MIDDLE AGED; MUTATION; OSTEOARTHRITIS, KNEE; SYNOVIAL FLUID; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 77957942420     PISSN: 03009742     EISSN: 15027732     Source Type: Journal    
DOI: 10.3109/03009741003677449     Document Type: Article

References (35)

1. Xie F, Lo N-N, Lee H-P, Cieza A, Li S-C. Validation of the International Classification of Functioning, Disability, and Health (ICF) Brief Core Set for osteoarthritis. Scand J Rheumatol 2008;37:450-61.
2. Madsen SH, Sondergaard BC, Bay-Jensen AC, Karsdal MA. Cartilage formation measured by a novel PIINP assay suggests that IGF-I does not stimulate but maintains cartilage formation ex vivo. Scand J Rheumatol 2009;38:222-6.
3. Carroll GJ. Polyarticular osteoarthritis: two major phenotypes hypothesized. Med Hypotheses 2006;66:315-18.
4. Allen KJ, Gurrin LC, Constantine CC, Osborne NJ, Delatycki MB, Nicoll AJ, et al. Iron-overload-related disease in HFE heredi-tary hemochromatosis. N Engl J Med 2008;358:221-30.
5. Schumacher HR Jr. Arthropathy in hemochromatosis. Hosp Pract (Minneap) 1998;33:81-6, 89-90, 93; discussion 93-84.
6. Vaiopoulos G, Papanikolaou G, Politou M, Jibreel I, Sakellaropoulos N, Loukopoulos D. Arthropathy in juvenile hemochromatosis. Arthritis Rheum 2003;48:227-30.
7. Economides AN, Carpenter LR, Rudge JS, Wong V, Koehler-Stec EM, Hartnett C, et al. Cytokine traps: multi-component, high-affinity blockers of cytokine action. Nature Med 2003;9:47-52.
8. Pelletier JP, DiBattista JA, Roughley P, McCollum R, Martel-Pelletier J. Cytokines and inflammation in cartilage degradation. Rheum Dis Clin North Am 1993;19:545-68.
9. Manicourt DH, Poilvache P, Van Egeren A, Devogelaer JP, Lenz ME, Thonar EJ. Synovial fluid levels of tumor necrosis factor alpha and oncostatin M correlate with levels of markers of the degradation of crosslinked collagen and cartilage aggrecan in rheumatoid arthritis but not in osteoarthritis. Arthritis Rheum 2000;43:281-8.
10. Carroll G, Bell M, Wang H, Chapman H, Mills J. Antagonism of the IL-6 cytokine subfamily-a potential strategy for more effect-ive therapy in rheumatoid arthritis. Inflamm Res 1998;47:1-7.
11. Plater-Zyberk C, Buckton J, Thompson S, Spaull J, Zanders E, Papworth J, et al. Amelioration of arthritis in two murine models using antibodies to oncostatin M. Arthritis Rheum 2001; 44:2697-702.
12. Tetlow LC, Adlam DJ, Woolley DE. Matrix met alloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis Rheum 2001;44:585-94.
13. Cawston T. Matrix met alloproteinases and TIMPs: properties and implications for the rheumatic diseases. Mol Med Today 1998;4:130-7.
14. Tchetverikov I, Lohmander LS, Verzijl N, Huizinga TW, TeKoppele JM, Hanemaaijer R, et al. MMP protein and activity levels in synovial fluid from patients with joint injury, inflamma-tory arthritis, and osteoarthritis. Ann Rheum Dis 2005; 64:694-8.
15. Tchetverikov I, Ronday HK, Van El B, Kiers GH, Verzijl N, TeKoppele JM, et al. MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis. Ann Rheum Dis 2004;63:881-3.
16. Kellgren JH. Atlas of standard radiographs. In: Jeffrey MR, Ball J, Eds. The Epidemiology of Chronic Rheumatism. Oxford: Black-well Scientific Publications; 1963:1-9.
17. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
18. Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996;13:399-408.
19. Swinkels DW, Janssen MCH, Bergmans J, Marx JJM. Hereditary hemochromatosis: genetic complexity and new diagnostic approaches. Clin Chem 2006;52:950-68.
20. Askari AD, Muir WA, Rosner IA, Moskowitz RW, McLaren GD, Braun WE. Arthritis of hemochromatosis. Clinical spectrum, rela-tion to histocompatibility antigens, and effectiveness of early phlebotomy. Am J Med 1983;75:957-65.
21. Milman N, Hansen SE, Strandberg Pedersen N. Synovial fluid ferritin in rheumatic diseases. Scand J Rheumatol 1985;14:33-6.
22. Reyes PA, Delgado EA, Lopez-Karpovitch X. Ferritin measure-ment in synovial tissue and fluid in patients with inflammatory joint disease. Rev Invest Clin 1986;38:135-8.
23. Ahmadzadeh N, Shingu M, Nobunaga M. Iron-binding proteins and free iron in synovial fluids of rheumatoid arthritis patients. Clin Rheumatol 1989;8:345-51.
24. Kumon Y, Suehiro T, Nishiya K, Hashimoto K, Nakatani K, Sipe JD. Ferritin correlates with C-reactive protein and acute phase serum amyloid A in synovial fluid, but not in serum. Amyloid 1999 1999;6:130-5.
25. Abe E, Arai M. Synovial fluid ferritin in traumatic hemarthrosis, rheumatoid arthritis and osteoarthritis. Tohoku J Exp Med 1992;168:499-505.
26. Klockars M, Pettersson T, Vilja P, von Essen R. Synovial fluid ferritin, lactoferrin and adenosine deaminase in rheumatic dis-eases. Br J Rheumatol 1990;29:318-19.
27. Carroll GJ. HFE gene mutations are associated with osteoarthritis in the index or middle finger metacarpophalangeal joints. J Rheu-matol 2006;33:741-3.
28. Olynyk JK, Cullen DJ, Aquilia S, Rossi E, Summerville L, Powell LW. A population-based study of the clinical expression of the hemochromatosis gene. N Engl J Med 1999;341:718-24.
29. Carroll G, Breidahl W, Jazayeri J. Confirmation of two major polyarticular osteoarthritis (POA) phenotypes-differentiation on the basis of joint topography. Osteoarthritis Cartilage 2009;17:891-5.
30. Alizadeh BZ, Njajou OT, Hazes JM, Hofman A, Slagboom PE, Pols HA, et al. The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis. Ann Rheum Dis 2007;66:1436-42.
31. Houssiau FA, Devogelaer J-P, Damme JV, Deuxchaisnes CND, Snick JV. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum 1988;31:784-8.
32. Swaak AJ, van Rooyen A, Nieuwenhuis E, Aarden LA. Interleukin-6 (IL-6) in synovial fluid and serum of patients with rheumatic diseases. Scand J Rheumatol 1988;17:469-74.
33. Cunnane G, Fitzgerald O, Beeton C, Cawston TE, Bresnihan B. Early joint erosions and serum levels of matrix met alloproteinase 1, matrix met alloproteinase 3, and tissue inhibitor of met alloprotei-nases 1 in rheumatoid arthritis. Arthritis Rheum 2001;44:2263-74.
34. Green MJ, Gough AK, Devlin J, Smith J, Astin P, Taylor D, et al. Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis. Rheumatology (Oxford) 2003;42:83-8.
35. Ruddell RG, Hoang-Le D, Barwood JM, Rutherford PS, Piva TJ, Watters DJ, et al. Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells. Hepatology 2009;49:887-900.