Sortilin is expressed in cultured human keratinocytes and is regulated by cutaneous neuropeptides

Journal of Investigative Dermatology

Volumn 130, Issue 11, 2010, Pages 2553-2560

  Kiss, Mária ^a   Dallos, Attila ^a   Kormos, Bernadett ^a   Sántha, Petra ^a   Dobozy, Attila ^a   Husz, Sándor ^a   Kemény, Lajos ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; DNA; GALANIN; MESSENGER RNA; SORTILIN; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADULT; APOPTOSIS; ARTICLE; DERMIS; DNA FRAGMENTATION; EPIDERMIS; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 77957933758     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.187     Document Type: Article

References (60)

1. Albers KM, Wright DE, Davis BM (1994) Overexpression of nerve growth factor in epidermis of transgenic mice causes hypertrophy of the peripheral nervous system. J Neurosci 14:1422-32
2. Althaus HH, Klöppner S (2006) Mature pig oligodendrocytes rapidly process human recombinant pro-nerve growth factor and do not undergo cell death. J Neurochem 98:506-17
3. Benrath J, Zimmermann M, Gillardon F (1995) Substance P and nitric oxide mediate wound healing of ultraviolet photodamaged rat skin: evidence for an effect of nitric oxide on keratinocyte proliferation. Neurosci Lett 200:17-20
4. Bondy B, Baghai TC, Minov C et al. (2003) Substance P serum levels are increased in major depression: preliminary results. Biol Psychiatry 53:538-42
5. Brenneman DE, Phillips TM, Hauser J et al. (2003) Complex array of cytokines released by vasoactive intestinal peptide. Neuropeptides 37:111-9
6. Bull HA, Leslie TA, Chopra S et al. (1998) Expression of nerve growth factor receptors in cutaneous inflammation. Brit J Dermatol 139:776-83
7. Burbach GJ, Kim KH, Zivony AS et al. (2001) The neurosensory tachykinins substance P and neurokinin A directly induce keratinocyte nerve growth factor. J Invest Dermatol 117:1075-82
8. Canuel M, Lefrancois S, Zeng J et al. (2008) AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes. Biochem Biophys Res Commun 366:724-30
9. Chang SE, Han SS, Jung HJ et al. (2007) Neuropeptides and their receptors in psoriatic skin in relation to pruritus. Br J Dermatol 156:1272-7
10. Dallos A, Kiss M, Polyanka H et al. (2006a) Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes. Neuropeptides 40:251-63
11. Dallos A, Kiss M, Polyanka H et al. (2006b) Galanin receptor expression in cultured human keratinocytes and in normal human skin. J Peripher Nerv Syst 11:156-64
12. Dechant G, Barde YA (1997) Signalling through the neutrophin receptor p75NTR. Curr Opin Neurobiol 7:413-8
13. Domeniconi M, Hempstead BL, Chao MV (2007) Pro-NGF secreted by astrocytes promotes motor neuron cell death. Mol Cell Neurosci 34:271-9
14. Haegerstrand A, Jonzon B, Dalsgaard CJ et al. (1989) Vasoactive intestinal polypeptide stimulates cell proliferation and adenylate cyclase activity of cultured human keratinocytes. Proc Natl Acad Sci USA 86:5993-6
15. Hassan AJ, ZengJ, Ni X etal. (2004) The trafficking of prosaposin (SGP-1) and GM2AP to the lysosomes of TM4 Sertoli cells is mediated by sortilin and monomeric adaptor proteins. Mol Reprod Dev 68:476-83
16. Hermans-Borgmeyer I, Hermey G, Nykjaer A et al. (1999) Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development. Brain Res Mol Brain Res 65:216-9
17. Hermey G (2009) The Vps10p-domain receptor family. Cell Mol Life Sci 66:2677-89
18. Hilliges M, Wang L, Johansson O (1995) Ultrastructural evidence for nerve fibers within all vital layers of the human epidermis. J Invest Dermatol 104:134-7
19. Ibanez CF (2002) Jekyll-Hyde neurotrophins: the story of proNGF. Trends Neurosci 25:284-6
20. Kaplan DR, Hempstead BL, Martin-Zanca D et al. (1991) The trk proto-oncogen product: a signal transducing receptor for nerve growth factor. Science 252:554-8
21. Kaplan DR, Miller FD (2004) Neurobiology: a move to sort life from death. Nature 427:798-9
22. Kemeny L, von Restorff B, Michel G et al. (1994) Specific binding and lack of growth-promoting activity of substance P in cultured human keratinocytes. J Invest Dermatol 103:605-6
23. Kiss M, Kemeny L, Gyulai R et al. (1999) Effects of the neuropeptides substance P, calcitonin gene-related peptide and alpha-melanocyte stimulating hormone on the IL-8/IL-8 receptor system in a cultured human keratinocyte cell line and dermal fibroblasts. Inflammation 23:557-67
24. Kliemannel M, Rattenholl A, Golbik R et al. (2004) The mature part of proNGF induces the structure of its propeptide. FEBS Lett 566:207-12
25. Koch TR, Michener SR, Go VL (1991) Plasma vasoactive intestinal polypeptide concentration determination in patients with diarrhea. Gastroenterology 100:99-106
26. Lee R, Kermani P, Teng KK et al. (2001) Regulation of cell survival by secreted proneurotrophins. Science 294:1945-8
27. Lefrancois S, Zeng J, Hassan AJ et al. (2003) The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin. EMBO J 22:6430-7
28. Lin BZ, Pilch PF, Kandror KV (1997) Sortilin is a major protein component of Glut4-containing vesicles. J Biol Chem 272:24145-7
29. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(\-Delta Delta C(T)). Method Methods 25:402-8
30. Lotti T, Hautmann G, Panconesi E (1995) Neuropeptides in skin. J Am Acad Dermatol 33:482-96
31. Di Marco E, Mathor M, Bondanza S et al. (1993) Nerve growth factor binds to normal human keratinocytes through high and low affinity receptors and stimulates their growth by a novel autocrine loop. J Biol Chem 268:22838-46
32. Marconi A, Truzzi F, Lotti R etal. (2008) p75 neurotrophin receptor restores defective apoptosis in psoriatic keratinocytes: a role for transit amplifying cells. J Invest Dermatol 128:S137 (abstract)
33. Marcusson EG, Horazdovsky BF, Cereghino JL et al. (1994) The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell 77:579-86
34. Mari M, Bujny MV, Zeuschner D et al. (2008) SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors. Traffic 9:380-93
35. Morris NJ, Ross SA, Lane WS et al. (1998) Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes. J Biol Chem 273:3582-7
36. Navarro V, Martin S, Sarret P et al. (2001) Pharmacological properties of the mouse neurotensin receptor 3. Maintenance of cell surface receptor during internalization of neurotensin. FEBS Lett 495:100-5
37. Nielsen MS, Jacobsen C, Olivecrona G et al. (1999) Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J Biol Chem 274:8832-6
38. Nykjaer A, Lee R, Teng KK et al. (2004) Sortilin is essential for proNGF-induced neuronal cell death. Nature 427:843-8
39. NTR-live or let die. Curr Opin Neurobiol 15:49-57
40. Okumura T, Shimada Y, Imamura M et al. (2003) Neurotrophin receptor p75(NTR) characterizes human esophageal keratinocyte stem cells in vitro. Oncogene 22:4017-26
41. Paiardini A, Caputo V (2008) Insights into the interaction of sortilin with proneurotrophins: a computational approach. Neuropeptides 42:205-14
42. Peters EM, Raap U, Welker P et al. (2007) Neurotrophins act as neuroendocrine regulators of skin homeostasis in health and disease. Horm Metab Res 39:110-24
43. Peters EMJ, Stieglitz MG, Liezman C et al. (2006) p75 neurotrophin receptor-mediated signaling promotes human hair follicle regression (catagen). Am J Pathol 168:221-34
44. Pincelli C, Sevignani C, Manfredini R et al. (1994) Expression and function of nerve growth factor and nerve growth factor receptor on cultured human keratinocytes. J Invest Dermatol 103:13-8
45. Pincelli C, Marconi A (2000) Autocrine nerve growth factor in human keratinocytes. J Dermatol Sci 22:71-9
46. Pincelli C, Yaar M (1997) Nerve growth factor: its significance in cutaneous biology. J Invest Dermatol Symp Proc 2:31-7
47. Raychaudhuri SP, Raychaudhuri SK (2004) Role of NGF and neurogen inflammation in the pathogenesis of psoriasis. Prog Brain Res 146:433-7
48. Reilly DM, Ferdinando D, Johnston C et al. (1997) The epidermal nerve fibre network: characterization of nerve fibres in human skin by confocal microscopy and assessment of racial variations. Br J Dermatol 137:163-70
49. Schifter S (1991) Circulating concentrations of calcitonin gene-related peptide (CGRP) in normal man determined with a new, highly sensitive radioimmunoassay. Peptides 12:365-9
50. Scholzen T, Armstrong CA, Bunnett NW et al. (1998) Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems. Exp Dermatol 7:81-96
51. Schweigreiter R (2006) The dual nature of neurotrophins. Bioessays 28:583-94
52. Segal RA (2003) Selectivity in neurotrophin signaling: theme and variations. Annu Rev Neurosci 26:299-330
53. Stander S, Schneider SW, Weishaupt C et al. (2009) Putative neuronal mechanisms of sensitive skin. Exp Dermatol 18:417-23
54. Takahashi K, Nakanishi S, Imamura S (1993) Direct effects of cutaneous neuropeptides on adenylyl cyclase activity and proliferation in a keratinocyte cell line: stimulation of cyclic AMP formation by CGRP and VIP/PHM, and inhibition by NPY through G protein-coupled receptors. J Invest Dermatol 101:646-51
55. Tron VA, Coughlin MD, Jang DE et al. (1990) Expression and modulation of nerve growth factor in murine keratinocytes (PAM 212). J Clin Invest 85:1085-9
56. Truzzi F, Marconi A, Atzei P et al. (2006) p75 neurotrophin receptor (p75NTR) signals apoptosis either alone or in association its co-receptor sortilin in human keratinocytes. J Invest Dermatol 126:S87 (abstract)
57. Truzzi F, Marconi A, Lotti R et al. (2008) Neurotrophins and their receptors stimulate melanoma cell proliferation and migration. J Invest Dermatol 128:2031-40
58. Volosin M, Song W, Almeida RD et al. (2006) Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins. J Neurosci 26:7756-66
59. Wang S, Hashemi T, Fried S et al. (1998) Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes. Biochemistry 37:6711-7
60. Wang X, Bauer JH, Li Y et al. (2001) Characterization of a p75(NTR) apoptotic signaling pathway using a novel cellular model. J Biol Chem 276:33812-20