The trafficking of prosaposin (SGP-1) and GM2AP to the lysosomes of TM4 sertoli cells is mediated by sortilin and monomeric adaptor proteins

Molecular Reproduction and Development

Volumn 68, Issue 4, 2004, Pages 476-483

  Hassan, A Jacob ^a   Zeng, Jibin ^a   Ni, Xiaoyan ^a   Morales, Carlos R ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

GM2 AP; Prosaposin; Sortilin; TM4 cells

Indexed keywords

ADAPTOR PROTEIN; ARF BINDING PROTEIN; CLATHRIN; GAMMA ADAPTIN; GANGLIOSIDE GM2 ACTIVATOR PROTEIN; GLYCOSPHINGOLIPID; HYDROLASE; MANNOSE 6 PHOSPHATE; MONOMER; MONOMERIC ADAPTOR PROTEIN; PHOSPHOTRANSFERASE; PROSAPOSIN; PROTEIN; SOMATOMEDIN B RECEPTOR; SORTILIN; SORTILIN RECEPTOR; SPHINGOLIPID; SPHINGOMYELIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL LINE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GGA BINDING MOTIF; GOLGI COMPLEX; LYSOSOME; MOUSE; MUCOLIPIDOSIS TYPE 2; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN TARGETING; PROTEIN TRANSPORT; SERTOLI CELL;

ANIMALS; G(M2) ACTIVATOR PROTEIN; GENES, REPORTER; GOLGI APPARATUS; GREEN FLUORESCENT PROTEINS; LYSOSOMES; MALE; MEMBRANE GLYCOPROTEINS; MICE; NERVE TISSUE PROTEINS; SAPOSINS; SERTOLI CELLS;

EID: 4143050395     PISSN: 1040452X     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrd.20096     Document Type: Article

References (23)

1. Collard MW, Sylvester SR, Tsuruta JK, Griswold MD. 1988. Biosynthesis and molecular cloning of sulfated glycoprotein-1 secreted by rat Sertoli cells: Sequence similarity with the 70-kilodalton precursor to sulfatide/GM1 activator. Biochemistry 27:4557-4564.
2. Cooper AA, Stevens TH. 1996. Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases. J Cell Biol 133:529-541.
3. Gkantiragas I, Brugger B, Stuven E, Kaloyanova D, Li XY, Lohr K, Lottspeich F, Wieland FT, Helms JB. 2001. Sphingomyelin-enriched microdomains at the Golgi complex. Mol Biol Cell 12:1819-1833.
4. Glickman JN, Kornfeld S. 1993. Mannose 6-phosphate-independent targeting of lysosomal enzymes in I-cell disease B lymphoblasts. J Cell Biol 123:99-108.
5. Hasilik A, Waheed A, von Figura K. 1981. Enzymatic phosphorylation of lysosomal enzymes in the presence of UDP-N-acetylglucosamine. Absence of the activity in I-cell fibroblasts. Biochem Biophys Res Commun 98:761-767.
6. Hermans-Borgemeyer I, Hermey G, Nykjaer A, Schaller C. 1999. Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development. Mol Brain Res 272:216-219.
7. Igdoura SA, Morales CR. 1995. Role of sulfated glycoprotein-1 (SPG-1) in the disposal of residual bodies by Sertoli cells of the rat. Mol Rep Dev 40:91-102.
8. Igdoura SA, Rasky A, Morales CR. 1996. Trafficking of sulfated glycoprotein-1 (prosaposin) to lysosomes or to the extracellular space in rat Sertoli cells. Cell Tissue Res 283:385-394.
9. Kornfeld S. 1992. Structure and function of the mannose 6-phosphate/ insulin like growth factor II receptors. Annu Rev Biochem 61:307-330.
10. Lefrancois S, May T, Knight C, Bourbeau D, Morales CR. 2002. The lysosomal transport of prosaposin requires the conditional interaction of its highly conserved D domain with sphingomyelin. J Biol Chem 277:17188-17199.
11. Lobel P, Fujimoto K, Ye RD, Griffiths G, Kornfeld S. 1989. Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis. Cell 57:787-796.
12. Marcusson EG, Horazdovsky HF, Cereghino JL, Gharakhanian E, Emr SD. 1994. The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS 10 gene. Cell 77:579-586.
13. Martin S, Navarro V, Vincent JP, Mazella J. 2002. Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line. Gastroenterology 123:1135-1143.
14. Nielsen MS, Madsen P, Christensen EI, Nykjaer A, Gliemann J, Kasper D, Pohlmann R, Petersen CM. 2001. The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. Embo J 20:2180-2190.
15. O'Brien JS, Kishimoto Y. 1991. Saposin proteins: Structure, function, and role in human lysosomal storage disorders. FASEB J 5:301-308.
16. Owada M, Neufeld EF. 1982. Is there a mechanism for introducing acid hydrolases into liver lysosomes that is independent of mannose 6-phosphate recognition? Evidence from I-cell disease. Biochem Biophys Res Commun 105:814-820.
17. Peden AA, Rudge RE, Lui WW, Robinsin MS. 2002. Assembly and function of AP-3 complexes in cells expressing mutant subunits. J Cell Biol 156:327-336.
18. Petersen CM, Nielsen MS, Nykjaer A, Jacobsen L, Tommerup N, Rasmussen HH, Roigaard H, Gliemann J, Madsen P, Moestrup SK. 1997. Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J Biol Chem 272:3599-3605.
19. Puertollano R, Aguilar RC, Gorshkova I, Crouch RJ, Bonifacino JS. 2001a. Sorting of mannose 6-phosphate receptors mediated by the GGAs. Science 292:1712-1726.
20. Puertollano R, Randazzo PA, Presley JF, Hartnell LM, Bonifacino JS. 2001b. The GGAs promote ARF-dependent recruitment of clathrin to the TGN. Cell 105:93-102.
21. Reitman ML, Varki A, Kornfeld S. 1981. Fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy are deficient in uridine 5′-diphosphate-N-acytlglucosamine. J Clin Invest 67:1574-1579.
22. Tsuji A, Omura K, Suzuki Y. 1988. I-cell disease: Evidence for a mannose 6-phosphate independent pathway for translocation of lysosomal enzymes in lymphoblastoid cells. Clin Chim Acta 176:115-121.
23. Waheed A, Pohlmann R, Hasilik A, von Figura K, van Elsen A, Leroy JG. 1982. Deficiency of UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase in organs of I-cell patients. Biochem Biophys Res Commun 105:1052-1058.