Impact of peripheral lymphocyte count on the sensitivity of 2 IFN-γ release assays, QFT-G and ELISPOT, in patients with pulmonary tuberculosis

Internal Medicine

Volumn 49, Issue 17, 2010, Pages 1849-1855

  Komiya, Kosaku ^a,b   Ariga, Haruyuki ^a   Nagai, Hideaki ^a   Teramoto, Shinji ^a   Kurashima, Atsuyuki ^a   Shoji, Syunsuke ^a   Nakajima, Yutsuki ^a  

^a NATIONAL HOSPITAL ORGANIZATION   (Japan)

^b OITA UNIVERSITY   (Japan)

Author keywords

IFN release assay; Lymphocyte count; Pulmonary tuberculosis

Indexed keywords

GAMMA INTERFERON;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOCOMPROMISED PATIENT; INTERMETHOD COMPARISON; LUNG LAVAGE; LUNG TUBERCULOSIS; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MYCOBACTERIUM TUBERCULOSIS; NUTRITIONAL STATUS; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; SPUTUM CULTURE;

AGED; COMORBIDITY; CONFOUNDING FACTORS (EPIDEMIOLOGY); ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HIV SERONEGATIVITY; HUMANS; IMMUNOCOMPROMISED HOST; INTERFERON-GAMMA; LYMPHOCYTE COUNT; LYMPHOPENIA; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; TUBERCULOSIS, PULMONARY;

EID: 77957922517     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.49.3659     Document Type: Article

References (36)

1. Mori T. Usefulness of interferon-gamma release assays for diagnosing TB infection and problems with these assays. J Infect Chemother 15: 143-155, 2009.
2. Richeldi L, Losi M, D'Amico R, et al. Performance of tests for latent tuberculosis in different groups of immunocompromised patients. Chest 136: 198-204, 2009.
3. Dheda K, van Zyl Smit R, Badri M, Pai M. T-cell interferongamma release assays for the rapid immunodiagnosis of tuberculosis: clinical utility in high-burden vs. low-burden settings. Curr Opin Pulm Med 15: 188-200, 2009.
4. Lee JY, Choi HJ, Park IN, et al. Comparison of two commercial interferon-gamma assays for diagnosing Mycobacterium tuberculosis infection. Eur Respir J 28: 24-30, 2006.
5. Pai M, Zwerling A, Menzies D. Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update. Ann Intern Med 149: 177-184, 2008.
6. Rangaka MX, Diwakar L, Seldon R, et al. Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans. Clin Infect Dis 44: 1639-1646, 2007.
7. Rangaka MX, Wilkinson KA, Seldon R, et al. Effect of HIV-1 infection on T-cell-based and skin test detection of tuberculosis infection. Am J Respir Crit. Care Med 175: 514-520, 2007.
8. Stephan C, Wolf T, Goetsch U, et al. Comparing QuantiFERONtuberculosis gold, T-SPOT tuberculosis and tuberculin skin test in HIV-infected individuals from a low prevalence tuberculosis country. AIDS 22: 2471-2479, 2008.
9. Balcells ME, Perez CM, Chanqueo L, et al. A comparative study of two different methods for the detection of latent tuberculosis in HIV-positive individuals in Chile. Int J Infect Dis 12: 645-652, 2008.
10. Raby E, Moyo M, Devendra A, et al. The effects of HIV on the sensitivity of a whole blood IFN-gamma release assay in Zambian adults with active tuberculosis. PLoS ONE 3: e2489, 2008.
11. Aabye MG, Ravn P, PrayGod G, et al. The impact of HIV infection and CD4 cell count on the performance of an interferon gamma release assay in patients with pulmonary tuberculosis. PLoS ONE 4: e4220, 2009.
12. Syed A, Kabeer B, Sikhamani R, et al. Role of interferon gamma release assay in active TB diagnosis among HIV infected individuals. PLoS ONE 4: e5718, 2009.
13. Aichelburg MC, Rieger A, Breitenecker F, et al. Detection and prediction of active tuberculosis disease by a whole-blood interferon-gamma release assay in HIV-1-infected individuals. Clin Infect Dis 48: 954-962, 2009.
14. Luetkemeyer AF, Charlebois ED, Flores LL, et al. Comparison of an interferon-gamma release assay with tuberculin skin testing in HIV-infected individuals. Am J Respir Crit Care Med 175: 737-742, 2007.
15. Nagai H, Kawabe Y, Ariga H, et al. Usefulness of a whole blood interferon gamma assay (QuantiFERON-TB-2G) for detecting tuberculosis infection in HIV-infected persons. Kekkaku 82: 635-640, 2007.
16. Ferrara G, Losi M, D'Amico R, et al. Use in routine clinical practice of two commercial blood tests for diagnosis of infection with Mycobacterium tuberculosis: a prospective study. Lancet 367: 1328-1334, 2006.
17. Lalvani A. Diagnosing tuberculosis infection in the 21st century: new tools to tackle an old enemy. Chest 131: 1898-1906, 2007.
18. Dominguez J, Ruiz-Manzano J, De Souza-Galvao M, et al. Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis. Clin Vaccine Immunol 15: 168-171, 2008.
19. Dheda K, Lalvani A, Miller RF, et al. Performance of a T-cellbased diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count. AIDS 19: 2038-2041, 2005.
20. Lawn SD, Bangani N, Vogt M, et al. Utility of interferon-gamma ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa. BMC Infect Dis 7: 99, 2007.
21. Mazurek GH, Jereb J, Lobue P, et al.; Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention. Guidlines for using the QuantiFERON-TB Gold test for detectiong Mycobacterium tuberculosis infection, United States. MMWR Recomm Rep 54: 49-55, 2005.
22. Winthrop KL, Nyendak M, Calvet H, et al. Interferon-gamma release assays for diagnosing Mycobacterium tuberculosis infection in renal dialysis patients. Clin J Am Soc Nephrol 3: 1357-1363, 2008.
23. Kang YA, Lee HW, Hwang SS, et al. Usefulness of whole-blood interferon-gamma assay and interferon-gamma enzyme-linked immunospot assay in the diagnosis of active pulmonary tuberculosis. Chest 132: 959-965, 2007.
24. Jones S, de Gijsel D, Wallach FR, Gurtman AC, Shi Q, Sacks H. Utility of QuantiFERON-TB Gold in-tube testing for latent TB infection in HIV-infected individuals. Int J Tuberc Lung Dis 11: 1190-1195, 2007.
25. Clark SA, Martin SL, Pozniak A, et al. Tuberculosis antigenspecific immune responses can be detected using enzyme-linked immunospot technology in human immunodeficiency virus (HIV)- 1 patients with advanced disease. Clin Exp Immunol 150: 238-244, 2007.
26. Mandalakas AM, Hesseling AC, Chegou NN, et al. High level of discordant IGRA results in HIV-infected adults and children. Int J Tuberc Lung Dis 12: 417-423, 2008.
27. Jones BE, Oo MM, Taikwel EK, et al. CD4 cell counts in human immunodeficiency virus-negative patients with tuberculosis. Clin Infect Dis 24: 988-991, 1997.
28. Santos JI. Nutrition, infection, and immunocompetence. Infect. Dis Clin North Am 8: 243-267, 1994.
29. Savendahl L, Underwood LE. Decreased interleukin-2 production from cultured peripheral blood mononuclear cells in human acute starvation. J Clin Endocrinol Metab 82: 1177-1180, 1997.
30. Pai M, Joshi R, Bandyopadhyay M, et al. Sensitivity of a wholeblood interferon-gamma assay among patients with pulmonary tuberculosis and variations in T-cell responses during antituberculosis treatment. Infection 35: 98-103, 2007.
31. Pathan AA, Wilkinson KA, Klenerman P, et al. Direct ex vivo analysis of antigen-specific IFN-gamma-secreting CD4 T cells in Mycobacterium tuberculosis-infected individuals: associations with clinical disease state and effect of treatment. J Immunol 167: 5217-5225, 2001.
32. Palaci M, Dietze R, Hadad DJ, et al. Cavitary disease and quantitative sputum bacillary load in cases of pulmonary tuberculosis. J Clin Microbiol 45: 4064-4066, 2007.
33. Kobashi Y, Mouri K, Obase Y, Fukuda M, Miyashita N, Oka M. Clinical evaluation of QuantiFERON TB-2G test for immunocompromised patients. Eur Respir J 30: 945-950, 2007.
34. Fedor ME, Rubinstein A. Effects of long-term low-dose corticosteroid therapy on humoral immunity. Ann. Allergy Asthma Immunol 97: 113-116, 2006.
35. Matulis G, Juni P, Villiger PM, Gadola SD. Detection of latent tuberculosis in immunosuppressed patients with autoimmune diseases: performance of a Mycobacterium tuberculosis antigenspecific interferon gamma assay. Ann Rheum Dis 67: 84-90, 2008.
36. Veerapathran A, Joshi R, Goswami K, et al. T-cell assays for tuberculosis infection: deriving cut-offs for conversions using reproducibility data. PLoS ONE 3: e1850, 2008.