Effect of nitric oxide modulation on the basic and rate-dependent electrophysiological properties of AV-node in the isolated heart of rabbit: The role of adrenergic and cholinergic receptors

Physiology and Pharmacology

Volumn 14, Issue 1, 2010, Pages 12-22

  Khori, Vahid ^a   Davarian, Ali ^a   Nayebpour, Mohsen ^b   Salaki, Saeed ^a   Salehi, Aref ^a   Shirafkan, Ahmad Ali ^a   Badaghabadi, Fakhri ^a   Pourabouk, Mona ^a   Alizadeh, Ali Mohammad ^c   Changizi, Shima ^a  

^a GOLESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Adrenergic; Cholinergic; Isolated AV node; Nitric oxide

Indexed keywords

ADRENERGIC RECEPTOR; ARGININE; ATROPINE; CHOLINERGIC RECEPTOR; N(G) NITROARGININE METHYL ESTER; NADOLOL; NITRIC OXIDE;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FACILITATION; FATIGUE; HEART ATRIOVENTRICULAR NODE; HEART ELECTROPHYSIOLOGY; INHIBITION KINETICS; ISOLATED HEART; MODULATION; NONHUMAN; RABBIT; RANDOMIZATION;

EID: 77957904350     PISSN: 17350581     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Alizadeh AM, Naseri M, Haji Zadeh S, NayebPour M, Khoori V. The role of Nitric Oxide in functional and tonic characteristics of rabbit AV-node. Physiology & Pharmacology journal 1(9) (2005) 1-7.
2. Balligand JL, Cannon P J .Nitric oxide synthesis and cardiac muscle, Autocrine and paracrine influences arteriosclerosis. Thrombosis and vascular biology. 17 (1997) 1846-1858.
3. Billette J, Amellal F. Functional properties of the AV node: Characterization and role in cardiac rhythms. In Mazgalev TN, Tchou PJ, Eds: Atrial-AV Nodal Electrophysiology: A View from the Millennium.Futura Publishing Co., Armonk, NY, (2000) 155-173.
4. Billette J, Nattel S. Dynamic behavior of the atrioventricular node: a functional model of interaction between recovery, facilitation, and fatigue. J Cardiovasc Electrophysiol. 1994; 5(1):90-102.
5. Chowdnary S., Townend N. Role of nitric oxide in the regulation of cardiovascular autonomic control .clinical science. 1999; 97: 5-17.
6. Elvan A, Rubart M, Zipes DP. NO modulates autonomic effects on sinus discharge rate and AV nodal conduction in open-chest dogs. Am J Physiol. 1997; 272 (1 Pt 2):H263-71.
7. Gupta S, McArthur C, Grady C, Ruderman NB. Stimulation of vascular Na (+)-K (+)-ATPase activity by nitric oxide: a cGMP-independent effect. Am J Physiol. 1994;266(5 Pt 2):H2146-51.
8. Han X, Kobzik L, Balligand J L, Kelly R A, Smith T W, Michel T. Nitric Oxide Synthase (NOS3) Mediated Cholinergic Modulation of Ca Current in Adult rabbit Atrioventricular Nodal Cells. Circ Res. 1996; 78: 998-1008.
9. Harvey RD, Belevych AE. Muscarinic regulation of cardiac ion channels. Br J Pharmacol .2003; 139(6):1074-84.
10. Jansen JA, van Veen TA, de Bakker JM, van Rijen HV. Cardiac connexins and Impulse propagation. J Mol Cell Cardiol. 2010; 48(1):76-82.
11. Kelly RA., Balligand JL., Smith TW. Nitric oxide and cardiac function. Circ Res. 1996; 79:363-380.
12. Khori V., Nayebpour M., Rakhshan E., Mirabbasi A. The effect of essence of Citrus aurantium on the rabbitAV-node. J Gorgan Univ Med Sci. 2006; 8(2): 1-7.
13. Krahn AD, Klein GJ, Yee R, Basta MN, Lee JK. Progressive anterior ablation in the coronary sinus region: evidence to support the presence of a 'slow pathway' input in normal patients? Circulation. 1997, 18; 96(10):3477-83.
14. Martynyuk A E, Kane K A, Cobbe S M, Rankin A C. Role of nitric Oxide, Cyclic GMP and Superoxide in Inhibition by Adenosine of Calcium Current in Rabbit Atrioventricular Nodal Cells. Cardiovascular Research. 1997; 34(2):360-367.
15. Massion PB, Feron O, Dessy C, Balligand JL. Nitric oxide and cardiac function: ten years after, and continuing. Circ Res. 2003; 5; 93(5):388-98.
16. Müller-Strahl G, Kottenberg K, Zimmer HG, Noack E, Kojda G. Inhibition of nitric oxide synthase augments the positive inotropic effect of nitric oxide donors in the rat heart. J Physiol. 2000, 15; 522 Pt 2:311-20. (Pubitemid 30068508)
17. Nayebpour M, Billetle J , Amella F , Nattel S. Effects of adenosine on rate - dependent atrioventricular nodal function. Circulation. 1993; 88:2632-2645.
18. Nayebpour M, Talajic M, Nattel S. Quantitation of dynamic AV nodal properties and application to predict rate-dependent AV conduction. Am J Physiol.1991; 261(2) - 2):H292-300.
19. Nayebpour M, Talajic M, Nattel S. Effects of beta-adrenergic receptor stimulation and blockade on rate-dependent atrioventricular nodal properties. Circ Res.1992; 70(5):902-11.
20. Nayebpour M, Talajic M, Villemaire C, Nattel S. Vagal modulation of the rate-dependent properties of the atrioventricular node. Circ Res.1990; 67(5):1152-66. (Pubitemid 20368013)
21. Paterson D, J. Nitric oxide and the autonomic regulation of cardiac excitability. Exp Physiol. 2001; 86(1):1-12.
22. Pinsky DJ, Patton S, Mesaros S, Brovkovych V, Kubaszewski E, Grunfeld S,Malinski T. Mechanical transduction of nitric oxide synthesis in the beating heart. Circ Res. 1997; 81(3):372-9.
23. Rakhit RD, Marber MS. Nitric oxide: an emerging role in cardioprotection? Heart. 2001; 86(4):368-72.
24. Reid MC, Billette J, Khalife K, Tadros R. Role of compact node and posterior extension in direction-dependent changes in atrioventricular nodal function in rabbit. J Cardiovasc Electrophysiol. 2003; 14(12):1342-50. (Pubitemid 38037473)
25. Strickberger SA, Daoud E, Niebauer M, Williamson BD, Man KC, Hummel JD, Morady F. Effects of partial and complete ablation of the slow pathway on fast pathway properties in patients with atrioventricular nodal reentrant tachycardia. J Cardiovasc Electrophysiol. 1994; 5(8):645-9. (Pubitemid 24278189)
26. Talajic M, Nayebpour M, Jing W, Nattel S. Frequency-dependent effects of diltiazem on the atrioventricular node during experimental atrial fibrillation. Circulation. 1989; 80(2):380-9. (Pubitemid 19195748)
27. Zima A, Martynyuk AE, Seubert CN, Morey TE, Sumners C, Cucchiara RF, Dennis DM. Antagonism of the Positive Dromotropic effect of Isoproterenol by Adenosine: role of Nitric Oxide, cGMP-Dependent cAMP-Phosphodiesterase and protein kinase G. J Mol Cell Cardiol. 2000; 32(9):1609-19.