Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones

Journal of Medicinal Chemistry

Volumn 53, Issue 19, 2010, Pages 7140-7145

  Christensen, Mette K ^a   Erichsen, Kamille D ^a   Trojel Hansen, Christina ^a,c   Tjørnelund, Jette ^a   Nielsen, Søren J ^a   Frydenvang, Karla ^b   Johansen, Tommy N ^b   Nielsen, Birgitte ^b   Sehested, Maxwell ^a,c   Jensen, Peter B ^a   Ikaunieks, Martins ^d   Zaichenko, Andrei ^d   Loza, Einars ^d   Kalvinsh, Ivars ^d   Björkling, Fredrik ^a,b  

^a BioAlliance Pharma   (France)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^d LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

Author keywords

[No Author keywords available]

Indexed keywords

3 CYCLOHEPTYL 3 (4 HYDROXYPHENYL) 6 METHOXY 7 METHYINDOLIN 2 ONE; ANTINEOPLASTIC AGENT; INDOLE DERIVATIVE; OXYPHENISATINE; UNCLASSIFIED DRUG; 3-CYCLOHEPTYL-3-(4-HYDROXYPHENYL)-6-METHOXY-7-METHYLINDOLIN-2-ONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TOLERABILITY; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PROSTATE CANCER; RAT; TUMOR REGRESSION; XENOGRAFT; ANIMAL; CANCER TRANSPLANTATION; DRUG SCREENING; FEMALE; NUDE MOUSE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INDOLES; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 77957891703     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100763j     Document Type: Article

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