677TT genotype is associated with elevated risk of methotrexate (MTX) toxicity in juvenile idiopathic arthritis: Treatment outcome, erythrocyte concentrations of MTX and folates, and MTHFR polymorphisms

Journal of Rheumatology

Volumn 37, Issue 10, 2010, Pages 2180-2186

  Tuková, Jana ^a   Chládek, Jaroslav ^b   Hroch, Milos ^a   Němcová, Dana ^b   Hoza, Jozef ^b   Doležalová, Pavla ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b Department of Pharmacology ^*  (Czech Republic)

Author keywords

Efficacy; Erythrocyte; Juvenile idiopathic arthritis; Methotrexate; MTHFR; Toxicity

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; METHOTREXATE;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ALOPECIA; ARTICLE; BEHAVIOR CHANGE; BONE MARROW SUPPRESSION; CHILD; DISEASE ACTIVITY; DISEASE DURATION; DRUG DOSE ESCALATION; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG INDUCED HEADACHE; ENZYME POLYMORPHISM; ERYTHROCYTE CONCENTRATE; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HYPERTRANSAMINASEMIA; JUVENILE RHEUMATOID ARTHRITIS; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MUCOSAL DISEASE; NAUSEA; NODULOSIS; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK ASSESSMENT; SCHOOL CHILD; SIDE EFFECT; STOMATITIS; TREATMENT OUTCOME; TREATMENT RESPONSE; VOMITING;

ADOLESCENT; ARTHRITIS, JUVENILE RHEUMATOID; CHILD; CHILD, PRESCHOOL; ERYTHROCYTES; FEMALE; FOLIC ACID; GENOTYPE; HUMANS; MALE; METHOTREXATE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, SINGLE NUCLEOTIDE; TREATMENT OUTCOME;

EID: 77957883315     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: 10.3899/jrheum.091427     Document Type: Article

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