Changes in human Langerhans cells following intradermal injection of influenza virus-like particle vaccines

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Pearton, Marc ^a   Kang, Sang Moo ^b   Song, Jae Min ^b   Anstey, Alexander V ^c   Ivory, Matthew ^a   Compans, Richard W ^b   Birchall, James C ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ANEURIN BEVAN UNIVERSITY HEALTH BOARD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VACCINE; INFLUENZA VIRUS LIKE VACCINE; UNCLASSIFIED DRUG; VIRUS VACCINE;

ARTICLE; CELL MIGRATION; CELL STRUCTURE; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DENDRITIC CELL; EX VIVO STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLUENZA VACCINATION; INTERFACE PRESSURE; INTRADERMAL DRUG ADMINISTRATION; KERATINOCYTE; LANGERHANS CELL; ORGAN CULTURE; SIGNAL TRANSDUCTION; SKIN; TISSUE SECTION; BACULOVIRUS; CELL COUNT; CYTOLOGY; EPIDERMIS; IMMUNOLOGY; INFLUENZA VIRUS A H1N1; METABOLISM;

ANIMALIA; ORTHOMYXOVIRIDAE;

BACULOVIRIDAE; CELL COUNT; EPIDERMIS; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INJECTIONS, INTRADERMAL; LANGERHANS CELLS; VIRAL VACCINES;

EID: 77957871770     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012410     Document Type: Article

References (46)

1. Miller KD, Gibbs RD, Mulligan NM, Nutman TB, Francis DP (1983) Intradermal hepatitis B virus vaccination: immunogenicity and side effects in adults. Lancet 2: 1454-1456.
2. WHO Publication (2010) Hepatitis B vaccines: WHO position paperrecommendations. Vaccine 28: 589-590.
3. Wu X, Franka R, Svoboda P, Pohl J, Rupprecht CE (2009) Development of combined vaccines for rabies and immunocontraception. Vaccine 27: 7202-7209.
4. Baldwin SL, Bertholet S, Kahn M, Zharkikh I, Ireton GC, et al. (2009) Intradermal immunization improves protective efficacy of a novel TB vaccine candidate. Vaccine 23: 3063-3071.
5. Cutts FT, Clements CJ, Bennett JV (1997) Alternative routes of measles immunization: a review. Biologicals 3: 323-338.
6. Nirmal S, Cherian T, Samuel BU, Rajasingh J, Raghupathy P, et al. (1998) Immune response of infants to fractional doses of intradermally administered inactivated poliovirus vaccine. Vaccine 16: 928-931.
7. Francis T, McGill T (1937) The antibody response of human subjects vaccinated with the virus of human influenza. J Exp Med 65: 251-529.
8. Chowell G, Viboud C, Wang X, Bertozzi SM, Miller MA (2009) Adaptive vaccination strategies to mitigate pandemic influenza: Mexico as a case study. PLoS One 4: e8164.
9. Shklovskaya E, Roediger B, Fazekas de St Groth B (2008) Epidermal and dermal dendritic cells display differential activation and migratory behaviour while sharing the ability to stimulate CD4+ T cell proliferation in vivo. J Immunol 181: 418-430.
10. de Jong MA, de Witte L, Geijtenbeek TB (2010) Isolation of immature primary Langerhans cells from human epidermal skin. Methods Mol Biol 595: 55-65.
11. Auewarakul P, Kositanont U, Sornsathapornkul P, Tothong P, Kanyok R, et al. (2007) Antibody responses after dose-sparing intradermal influenza vaccination. Vaccine 25: 659-663.
12. Merad M, Ginhoux F, Collin M (2008) Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. Nat Rev Immunol 12: 935-947.
13. Lambert PH, Laurent PE (2008) Intradermal vaccine delivery: will new delivery systems transform vaccine administration? Vaccine 26: 3197-3208.
14. Nishibu A, Ward BR, Boes M, Takashima A (2007) Roles for IL-1 and TNF alpha in dynamic behavioral responses of Langerhans cells to topical hapten application. J Dermatol Sci 45: 23-30.
15. Stutte S, Jux B, Esser C, Forster I (2008) CD24a expression levels discriminate Langerhans cells from dermal dendritic cells in murine skin and lymph nodes. J Invest Dermatol 128: 1470-1475.
16. Wang B, Amerio P, Sauder DN (1999) Role of cytokines in epidermal Langerhans cell migration. J Leukoc Biol 66: 33-39.
17. Dearman RJ, Bhushan M, Cumberbatch M, Kimber I, Griffiths CE (2004) Measurement of cytokine expression and Langerhans cell migration in human skin following suction blister formation. Exp Dermatol 7: 452-460.
18. Furio L, Briotet I, Journeaux A, Billard H, Péguet-Navarro J (2010) Human Langerhans Cells Are More Efficient Than CD14-CD1c+ Dermal Dendritic Cells at Priming Naive CD4+ T Cells. J Invest Dermatol 130: 1345-1354.
19. Gschwandtner M, Rossbach K, Dijkstra D, Bäumer W, Kietzmann M, et al. (2009) Murine and human Langerhans cells express a functional histamine H receptor: modulation of cell migration and function. Allergy, In press.
20. Schwarz A, Noordegraaf M, Maeda A, Torii K, Clausen BE, et al. (2010) Langerhans cells are required for UVR-induced immunosuppression. J Invest Dermatol 130: 1419-1427.
21. Tran JN, Pupovac A, Taylor RM, Wiley JS, Byrne SN, et al. (2010) Murine epidermal Langerhans cells and keratinocytes express functional P2X(7) receptors. Exp Dermatol, In press.
22. Kissenpfennig A, Henri S, Dubois B, Laplace-Builhé C, Perrin P, et al. (2005) Dynamics and Functions of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22: 643-654.
23. Mestas J, Hughes CCW (2004) Of mice and not men: differences between mouse and human immunology. J Immunol 172: 2731-2738.
24. Belshe RB, Newman FK, Cannon J, Duane C, Treanor J, et al. (2004) Serum antibody responses after intradermal vaccination against influenza. N Engl J Med 351: 2286-2294.
25. Beran J, Ambrozaitis A, Laiskonis A, Mickuviene N, Bacart P, et al. (2009) Intradermal influenza vaccination of healthy adults using a new microinjection system: a 3-year randomised controlled safety and immunogenicity trial. BMC Med 7: 13.
26. Chiu SS, Peiris JS, Chan KH, Wong WH, Lau YL (2007) Immunogenicity and safety of intradermal influenza immunization at a reduced dose in healthy children. Pediatrics 119: 1076-1082.
27. Holland D, Booy R, De Looze F, Eizenberg P, McDonald J, et al. (2008) Intradermal influenza vaccine administered using a new microinjection system produces superior immunogenicity in elderly adults: a randomized controlled trial. J Infect Dis 198: 650-658.
28. Kenney RT, Frech SA, Muenz LR, Villar CP, Glenn GM (2004) Dose sparing with intradermal injection of influenza vaccine. N Engl J Med 351: 2295-2301.
29. Sugimura T, Ito Y, Tananari Y, Ozaki Y, Maeno Y, et al. (2008) Improved antibody responses in infants less than 1 year old using intradermal influenza vaccination. Vaccine 26: 2700-2705.
30. Van Damme P, Oosterhuis-Kafeja F, Van der Wielen M, Almagor Y, Sharon O, et al. (2009) Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults. Vaccine 27: 454-459.
31. Ng KW, Pearton M, Coulman S, Anstey A, Gateley C, et al. (2009) Development of an ex vivo human skin model for intradermal vaccination: tissue viability and Langerhans cell behavior. Vaccine 27: 5948-5955.
32. Bright RA, Carter DM, Crevar CJ, Toapanta FR, Steckbeck JD, et al. (2008) Cross-Clade Protective Immune Responses to Influenza Viruses with H5N1 HA and NA Elicited by an Influenza Virus-Like Particle. PLoS One 3: e1501.
33. Haynes JR, Dokken L, Wiley JA, Cawthon AG, Bigger J, et al. (2009) Influenzapseudotyped Gag virus-like particle vaccines provide broad protection against highly pathogenic avian influenza challenge. Vaccine 27: 530-541.
34. Kang SM, Song JM, Quan FS, Compans RW (2009) Influenza vaccines based on virus-like particles. Virus Res 143: 140-146.
35. Quan FS, Huang C, Compans RW, Kang SM (2007) Virus-like particle vaccine induces protective immunity against homologous and heterologous strains of influenza virus. J Virol 81: 3514-3524.
36. Griffiths CE, Dearman RJ, Cumberbatch M, Kimber I (2005) Cytokines and Langerhans cell mobilisation in mouse and man. Cytokine 32: 67-70.
37. Quan FS, Kim YC, Yoo DG, Compans RW, Prausnitz MR, et al. (2009) Stabilization of influenza vaccine enhances protection by microneedle delivery in the mouse skin. PLoS One 4: e7152
38. Novavax website (accessed 2010) http://www.novavax.com/go.cfm?do=Page.View&pids=81/.
39. Pearton M, Kang SM, Song J-M, Kim Y-C, Quan FS, et al. (2010) Influenza Virus-Like Particles coated onto microneedles can elicit stimulatory effects on Langerhans cells in human skin. Vaccine, In press.
40. Rambukkana A, Bos JD, Irik D, Menko WJ, Kapsenberg ML, et al. (1995) In situ behaviour of human Langerhans cells in skin organ culture. Lab Invest 73: 521-531.
41. Larsen CP, Steinman RM, Witmer-Pack M, Hankins DF, Morris PJ, et al. (1990) Migration and maturation of Langerhans cells in skin transplants and explants. J Exp Med 172: 1483-1493.
42. Swetman CA, Leverrier Y, Garg R, Gan CH, Ridley AJ, et al. (2002) Extension, retraction and contraction in the formation of a dendritic cell dendrite: distinct roles for Rho GTPases. Eur J Immunol 32: 2074-2083.
43. Van Wilsem EJG, Breve J, Kleijmeer M, Kraal G (2004) Antigen-bearing Langerhans cells in skin draining lymph nodes: phenotype and kinetics of migration. J Invest Dermatol 103: 217-220.
44. Birchall J, Coulman S, Pearton M, Allender C, Brain K, et al. (2005) Cutaneous DNA delivery and gene expression in ex vivo human skin explants via wet-etch micro-fabricated micro-needles. J Drug Target 13: 415-421.
45. Quan FS, Yoo DG, Song JM, Clements JD, Compans RW, et al. (2009) Kinetics of immune responses to influenza virus-like particles and dose-dependence of protection with a single vaccination. J Virol 83: 4489-4497.
46. Laurent PE (2007) Evaluation of the clinical performance of a new intradermal vaccine administration technique and associated delivery system. Vaccine 25: 8833-8842.