First report on the patient database for the identification of the genetic pathways involved in patients over-reacting to radiotherapy: GENEPI-II

Radiotherapy and Oncology

Volumn 97, Issue 1, 2010, Pages 36-39

  De Ruysscher, Dirk ^a   Severin, Diane ^b   Barnes, Elizabeth ^c   Baumann, Michael ^d   Bristow, Rob ^e   Grégoire, Vincent ^f   Hölscher, Tobias ^d   Veninga, Theo ^g   Polański, Andrzej ^h   Veen, Evert Ben Van ⁱ   Verfaillie, Christine ^j   Heeren, Germaine ^k   Damaraju, Sambasivarao ^b   Just, Uwe ^d   Haustermans, Karin ⁱ  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF ALBERTA   (Canada)

^c DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^e UNIVERSITY OF TORONTO   (Canada)

^f CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^g Institute Verbeeten   (Netherlands)

^h SILESIAN UNIVERSITY OF TECHNOLOGY   (Poland)

ⁱ Med Law Consult   (Netherlands)

^j European Society for Therapeutic Radiology and Oncology   (Belgium)

^k UNIVERSITY HOSPITALS LEUVEN   (Belgium)

more..

Author keywords

Biomarkers; GENEPI; Genetic pathways; Hypersensitivity; Late effects; Over reactors; Prediction; Radiotherapy; Tissue banking

Indexed keywords

ADULT; AGED; ARTICLE; DATA BASE; FEMALE; HEAD AND NECK CANCER; HUMAN; HYPERSENSITIVITY; LUNG NON SMALL CELL CANCER; LYMPHOMA; MALE; MENINGIOMA; PRIORITY JOURNAL; RADIATION; RADIATION DOSE; RADIATION INJURY; SKIN FIBROBLAST;

AGED; BREAST NEOPLASMS; CANADA; EUROPE; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; LUNG NEOPLASMS; LYMPHOMA; MALE; MENINGIOMA; MIDDLE AGED; RADIATION INJURIES; RADIATION TOLERANCE; RADIOTHERAPY; RADIOTHERAPY DOSAGE; TISSUE BANKS; TUMOR MARKERS, BIOLOGICAL;

EID: 77957863710     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2010.03.012     Document Type: Article

References (15)

1. B. Emami, J. Lyman, and A. Brown Tolerance of normal tissue to therapeutic irradiation Int J Radiat Oncol Biol Phys 2 1991 109 122
2. M. Baumann, T. Hölscher, and A.C. Begg Towards genetic prediction of radiation responses: ESTRO's GENEPI project Radiother Oncol 69 2003 121 125
3. S.M. Bentzen Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology Nat Rev Cancer 6 2006 702 713
4. G.C. Barnett, C.M. West, and A.M. Dunning Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype Nat Rev Cancer 9 2009 134 142
5. I. Turesson Individual variation and dose dependency in the progression rate of skin telangiectasia Int J Radiat Oncol Biol Phys 19 1990 1569 1574
6. START Trialists' Group S.M. Bentzen, R.K. Agrawal, and E.G. Aird The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial Lancet Oncol 9 2008 331 341
7. C.N. Andreassen, and J. Alsner Genetic variants and normal tissue toxicity after radiotherapy: a systematic review Radiother Oncol 92 2009 299 309
8. T. Hölscher, S.M. Bentzen, and M. Baumann Influence of connective tissue diseases on the expression of radiation side effects: a systematic review Radiother Oncol 78 2006 123 130
9. C.N. Andreassen, J. Alsner, and J. Overgaard TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer Radiother Oncol 75 2005 18 21
10. J. Werbrouck, K. De Ruyck, and F. Duprez Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes Int J Radiat Oncol Biol Phys 73 2009 1187 1195
11. M.S. Meyn Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene Clin Genet 55 1999 289 304
12. P.M. Girard, N. Foray, and M. Stumm Radiosensitivity in Nijmegen Breakage Syndrome cells is attributable to a repair defect and not cell cycle checkpoint defects Cancer Res 60 2000 4881 4888
13. H. Bartsch, H. Dally, and O. Popanda Genetic risk profiles for cancer susceptibility and therapy response Recent Results Cancer Res 174 2007 19 36
14. C.M. West, M.J. McKay, and T. Hölscher Molecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting Int J Radiat Oncol Biol Phys 62 2005 1264 1273
15. N.G. Burnet, R.M. Elliott, A. Dunning, and C.M. West Radiosensitivity, radiogenomics and RAPPER Clin Oncol (R Coll Radiol) 18 2006 525 528