Treatment of bacterial vaginosis: A multicenter, double-blind, double-dummy, randomised phase III study comparing secnidazole and metronidazole

Infectious Diseases in Obstetrics and Gynecology

Volumn 2010, Issue , 2010, Pages

  Bohbot, Jean Marc ^a   Vicaut, Eric ^b   Fagnen, Didier ^c   Brauman, Michel ^c  

^a INSTITUT ALFRED FOURNIER   (France)

^b HÔPITAL FERNAND WIDAL   (France)

^c IPRAD 174 ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

METRONIDAZOLE; PLACEBO; SECNIDAZOLE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; FEMALE; GRAM STAINING; HUMAN; MAJOR CLINICAL STUDY; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; UNSPECIFIED SIDE EFFECT; VAGINA DISCHARGE; VAGINITIS;

ADOLESCENT; ADULT; AGED; ANTI-INFECTIVE AGENTS; CHI-SQUARE DISTRIBUTION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; METRONIDAZOLE; MIDDLE AGED; PROSPECTIVE STUDIES; TREATMENT OUTCOME; VAGINOSIS, BACTERIAL;

EID: 77957853252     PISSN: 10647449     EISSN: 10980997     Source Type: Journal    
DOI: 10.1155/2010/705692     Document Type: Article

References (22)

1. Livengood C. H., Bacterial vaginosis: an overview for 2009 Reviews In Obstetrics And Gynecology 2009 2 1 28 37
2. Oduyebo O. O., Anorlu R. I., Ogunsola F. T., The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women Cochrane Database of Systematic Reviews 2009 3
3. Donders G. G., Van Calsteren K., Bellen G., Reybrouck R., Van den Bosch T., Riphagen I., Van Lierde S., Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy An International Journal of Obstetrics and Gynaecology 2009 116 10 1315 1324
4. Workowski K. A., Berman S. M., Sexually transmitted diseases treatment guidelines Morbidity and Mortality Weekly Report 2006 55 RR11 1 94
5. Sherrard J., European guideline for the management of vaginal discharge International Journal of STD and AIDS 2001 12 supplement 3 73 77
6. Brandt M., Abels C., May T., Lohmann K., Schmidts-Winkler I., Hoyme U. B., Intravaginally applied metronidazole is as effective as orally applied in the treatment of bacterial vaginosis, but exhibits significantly less side effects European Journal of Obstetrics Gynecology and Reproductive Biology 2008 141 2 158 162
7. Gillis J. C., Wiseman L. R., Secnidazole: a review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis Drugs 1996 51 4 621 638
8. Nez J. T., Gmez G., Low-dose secnidazole in the treatment of bacterial vaginosis International Journal of Gynecology and Obstetrics 2005 88 3 281 285
9. Saraolu F., Gl K., ahin., Trkkani B., Atalay C., ztopu C., Treatment of bacterial vaginosis with oral or vaginal ornidazole, secnidazole and metronidazole International Journal of Gynecology and Obstetrics 1998 62 1 59 61
10. Birley H., Duerden B. I., Hart C. A., Sexually transmitted diseases: microbiology and management Journal of Medical Microbiology 2002 51 10 793 807
11. Food and Drug Administration, Guidance for industry. Bacterial vaginosisDeveloping antimicrobial drugs for treatment. July 1998
12. Lugo-Miro V. I., Green M., Mazur L., Comparison of different metronidazole therapeutic regimens for bacterial vaginosis: a meta-analysis Journal of the American Medical Association 1992 268 1 92 95
13. Andres F. J., Parker R., Hosein I., Benrubi G. I., Clindamycin vaginal cream versus oral metronidazole in the treatment of bacterial vaginosis: a prospective double-blind clinical trial Southern Medical Journal 1992 85 11 1077 1080
14. Anukam K., Osazuwa E., Ahonkhai I., Ngwu M., Osemene G., Bruce A. W., Reid G., Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial Microbes and Infection 2006 8 6 1450 1454
15. Buranawarodomkul P., Chandeying V., Sutthijumroon S., Seven day metronidazole versus single dose tinidazole as therapy for nonspecific vaginitis Journal of the Medical Association of Thailand 1990 73 5 283 287
16. Fischbach F., Petersen E. E., Weissenbacher E. R., Martius J., Hosmann J., Mayer H., Efficacy of clindamycin vaginal cream versus oral metronidazole in the treatment of bacterial vaginosis Obstetrics and Gynecology 1993 82 3 405 410
17. Greaves W. L., Chungafung J., Morris B., Haile A., Townsend J. L., Clandamycin versus metronidazole in the treatment of bacterial vaginosis Obstetrics and Gynecology 1988 72 5 799 802
18. Paavonen J., Mangioni C., Martin M. A., Wajszczuk C. P., Vaginal clindamycin and oral metronidazole for bacterial vaginosis: a randomized trial Obstetrics and Gynecology 2000 96 2 256 260
19. Schmitt C., Sobel J. D., Meriwether C., Bacterial vaginosis: treatment with clindamycin cream versus oral metronidazole Obstetrics and Gynecology 1992 79 6 1020 1023
20. Larsson P.-G., Livengood C. H. III, Bacterial vaginosis treatment evaluation before one month is not accurate American Journal of Obstetrics and Gynecology 1995 172 5 1638 1639
21. Larsson P. G., Forsum U., Bacterial vaginosisa disturbed bacterial flora and treatment enigma APMIS 2005 113 5 305 316
22. Amsel R., Totten P. A., Spiegel C. A., Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations American Journal of Medicine 1983 74 1 14 22