Development of 3-aryl-1-isoquinolinamines as potent antitumor agents based on CoMFA

European Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2010, Pages 5493-5497

  Yang, Su Hui ^a   Van, Hue Thi My ^a   Le, Thanh Nguyen ^a   Khadka, Daulat Bikram ^a   Cho, Suk Hee ^a   Lee, Kyung Tae ^b   Lee, Eung Seok ^c   Lee, Young Bok ^d   Ahn, Chang Ho ^d   Cho, Won Jea ^a  

^a Chonnam National University   (South Korea)

^b Kyung Hee University   (South Korea)

^c Yeungnam University   (South Korea)

^d Rexahn Pharmaceuticals Inc   (United States)

Author keywords

Antitumor agents; Apoptosis; Cell cycle arrest; CoMFA; Synthesis

Indexed keywords

3 (3 METHOXYPHENYL) 7 METHYLISOQUINOLIN 1 AMINE; 3 (3,4 DIMETHOXYPHENYL) 6 METHYLISOQUINOLIN 1 AMINE; 3 (3,4 DIMETHOXYPHENYL) N5,N5 DIMETHYLISOQUINOLIN 1,5 DIAMINE; 3 (3,5 DIMETHOXYPHENYL) 6,7 DIMETHOXYISOQUINOLIN 1 YLAMINE; 3 (4 METHOXY 2 METHYLPHENYL) 6 METHYLISOQUINOLIN 1 AMINE; 3 (BENZO[D][1,3]DIOXOL 6 YL) 6 METHYLISOQUINOLIN 1 AMINE; 6 METHYL 3 (2,6 DIMETHYLPHENYL)ISOQUINOLIN 1 AMINE; 6 METHYL 3 4 TOLYLISOQUINOLIN 1 AMINE; 6 METHYL 3 M TOLYLISOQUINOLIN 1 AMINE; 6,7 DIMETHOXY 3 (3 METHOXYPHENYL)ISOQUINOLIN 1 AMINE; 6,7 DIMETHOXY 3 O TOLYLISOQUINOLIN 1 YLAMINE; 6,7 DIMETHOXY 3 PHENYLISOQUINOLIN 1 AMINE; 7 METHYL 3 O TOLYLISOQUINOLIN 1 AMINE; ANTINEOPLASTIC AGENT; ISOQUINOLINE DERIVATIVE; N 5,N 5 DIMETHYL 3 O TOLYLISOQUINOLIN 1,5 DIAMINE; N 5,N 5 DIMETHYL 3 PHENYLISOQUINOLIN 1,5 DIAMINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; COMPARATIVE MOLECULAR FIELD ANALYSIS; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; FLOW CYTOMETRY; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; HUMAN; HUMAN CELL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

AMINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; FLOW CYTOMETRY; HUMANS; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY;

EID: 77957852330     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.08.042     Document Type: Article

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