Synthesis and antimicrobial activity of 2-substituted [4-(1,3,4-oxadiazol- 2-yl methyl)] phthalazin-1(2H)-one derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2010, Pages 4983-4989

  Sridhara, Ajjanna M ^a,b   Venugopala Reddy, Kallam R ^b   Keshavayya, Jathi ^b   Kumar Goud, Palusa Sanath ^a   Somashekar, Bankavadi C ^a   Bose, Prosenjit ^a   Peethambar, Sanenahalli K ^b   Gaddam, Satish Kumar ^a  

^a Advinus Therapeutics Private Limited Bangalore   (India)

^b KUVEMPU UNIVERSITY   (India)

Author keywords

(3 Oxo 2 benzofuran 1(3H) ylidene) acetic acid; (4 Oxo 3,4 dihydrophthalazin 1 yl)acetic acid; 1,3,4 Oxadiazole; Antibacterial; Antifungal; Biological assays; Phthalazin 1(2H) one

Indexed keywords

2 [(2 CHLORO 1,3 THIAZOL 5 YL)METHYL] 4 [(5 CYCLOPROPYL 1,3,4 OXADIAZOL 2 YL)METHYL]PHTHALAZIN 1(2H) ONE; 2 [(2 CHLORO 1,3 THIAZOL 5 YL)METHYL] 4 [[5 (2 METHYLPHENYL)1,3,4 OXADIAZOL 2 YL] METHYL]PHTHALAZIN 1(2H) ONE; 2 [(2 CHLORO 1,3 THIAZOL 5 YL)METHYL] 4 [[5 (4 FLUOROPHENYL) 1,3,4 OXADIAZOL 2 YL] METHYL]PHTHALAZIN 1(2H) ONE; 2 [(2 CHLORO 1,3 THIAZOL 5 YL)METHYL] 4 [[5 (THIOPHEN 3 YL) 1,3,4 OXADIAZOL 2 YL]METHYL]PHTHALAZIN 1(2H) ONE; 2 [(2 CHLORO 1,3 THIAZOL 5 YL)METHYL] 4 [[5 (TRIFLUOROMETHYL) 1,3,4 OXADIAZOL 2 YL] METHYL]PHTHALAZIN 1(2H) ONE; 2 [(2-CHLORO 1,3 THIAZOL 5 YL)METHYL] 4-[(5 METHYL 1,3,4 OXADIAZOL 2 YL)METHYL]PHTHALAZIN 1(2H) ONE; 2 [(6 CHLOROPYRIDIN 3 YL)METHYL] 4 [(5 CYCLOPROPYL 1,3,4 OXADIAZOL 2 YL)METHYL]PHTHALAZIN 1(2H) ONE; 2 [(6 CHLOROPYRIDIN 3 YL)METHYL] 4 [(5 METHYL 1,3,4 OXADIAZOL 2 YL)METHYL]PHTHALAZIN 1(2H) ONE; 2 [(6 CHLOROPYRIDIN 3 YL)METHYL] 4 [[5 (2 METHYLPHENYL) 1,3,4 OXADIAZOL 2 YL]METHYL] PHTHALAZIN 1(2H) ONE; 2 [(6 CHLOROPYRIDIN 3 YL)METHYL] 4 [[5 (4 FLUOROPHENYL) 1,3,4 OXADIAZOL 2 YL]METHYL]PHTHALAZIN 1(2H) ONE; 2 [(6 CHLOROPYRIDIN 3 YL)METHYL] 4 [[5 (6 CHLOROPYRIDIN 3 YL) 1,3,4 OXADIAZOL 2 YL] METHYL]PHTHALAZIN 1(2H) ONE; 2 [(6 CHLOROPYRIDIN 3 YL)METHYL] 4 [[5 (THIOPHEN 3 YL) 1,3,4 OXADIAZOL 2 YL]METHYL] PHTHALAZIN 1(2H) ONE; 2 [2 (MORPHOLIN 4 YL)ETHYL] 4 [[5 (4 FLUOROPHENYL) 1,3,4 OXADIAZOL 2 YL]METHYL]PHTHALAZIN 1(2H) ONE; 2 [2 (MORPHOLIN 4 YL)ETHYL] 4 [[5 (4 METHOXYPHENYL) 1,3,4 OXADIAZOL 2 YL]METHYL]PHTHALAZIN 1(2H) ONE; 2 [2 (MORPHOLIN 4 YL)ETHYL] 4 [[5 (5 BROMOPYRIDINYL 3 YL) 1,3,4 OXADIAZOL 2 YL]METHYL]PHTHALAZIN 1(2H) ONE; 2 [2 (MORPHOLIN 4 YL)ETHYL] 4 [[5 (6 CHLOROPYRIDINYL 3 YL) 1,3,4 OXADIAZOL 2 YL]METHYL]PHTHALAZIN 1(2H) ONE; 2 [2 (MORPHOLIN 4 YL)ETHYL] 4 [[5 (CYCLOPROPYL) 1,3,4 OXADIAZOL 2 YL]METHYL]PHTHALAZIN 1(2H) ONE; 2 [2 (MORPHOLIN 4 YL)ETHYL] 4 [[5 (THIOPHEN 3 YL) 1,3,4 OXADIAZOL 2 YL]METHYL]PHTHALAZIN 1(2H) ONE; 2 [2 (MORPHOLIN 4 YL)ETHYL] 4 [[5 (TRIFLUOROMETHYL) 1,3,4 OXADIAZOL 2 YL]METHYL]PHTHALAZIN 1(2H) ONE; 2 [6 (CHLOROPYRIDIN 3 YL)METHYL] 4 [[5 (TRIFLUOROMETHYL) 1,3,4 OXADIAZOL 2 YL]METHYL]PHTHALAZIN 1(2H) ONE; 4 [(5 METHYL 1,3,4 OXADIAZOL 2 YL)METHYL] 2 [2 (MORPHOLIN 4 YL)ETHYL]PHTHALAZIN 1(2H) ONE; 4 [[5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YL]METHYL] 2 [(2 CHLORO 1,3 THIAZOL 5 YL) METHYL] PHTHALAZIN 1(2H) ONE; 4 [[5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOL 2 YL]METHYL] 2 [(6 CHLOROPYRIDIN 3 YL)METHYL]PHTHALAZIN 1(2H) ONE; 4 [[5 (6 CHLOROPYRIDIN 3 YL) 1,3,4 OXADIAZOL 2 YL]METHYL] 2 [(2 CHLORO 1,3 THIAZOL 5 YL)METHYL]PHTHALAZIN 1(2H) ONE; AMOXICILLIN; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; METRONIDAZOLE; PHTHALAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; CHRYSOSPORIUM; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; FUNGAL STRAIN; GROWTH INHIBITION; MICROBIAL GROWTH; MICROSPORUM; NONHUMAN; SALMONELLA TYPHI; STAPHYLOCOCCUS AUREUS;

ANTI-INFECTIVE AGENTS; BACTERIA; FUNGI; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PHTHALAZINES; SPECTROPHOTOMETRY, INFRARED;

EID: 77957837221     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.08.005     Document Type: Article

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