Embryo aneuploidy and the role of morphological and genetic screening

Reproductive BioMedicine Online

Volumn 21, Issue 3, 2010, Pages 274-277

  Wells, Dagan ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

aneuploidy; chromosome; embryo; morphology; preimplantation genetic diagnosis; preimplantation genetic screening

Indexed keywords

ANEUPLOIDY; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; COMPARATIVE GENOMIC HYBRIDIZATION; DIAGNOSTIC ACCURACY; EMBRYO TRANSFER; EMBRYOTOXICITY; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC SCREENING; HUMAN; NOTE; OOCYTE; PREIMPLANTATION EMBRYO; RELIABILITY;

ANEUPLOIDY; BLASTOCYST; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; GENETIC TESTING; HUMANS; INFANT, NEWBORN; PREGNANCY; PREGNANCY OUTCOME; PREIMPLANTATION DIAGNOSIS;

EID: 77957836369     PISSN: 14726483     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rbmo.2010.06.035     Document Type: Note

References (29)

1. Alfarawati, S., Fragouli, E., Colls, P., et al., 2010. The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender. Fertil. Steril., in press, doi:10.1016/j.fertnstert.2010.04.003 .
2. E.B. Baart , D. Van Opstal , F.J. Los , B.C. Fauser , and E. Martini Fluorescence in-situ hybridization analysis of two blastomeres from day-3 frozen-thawed embryos followed by analysis of the remaining embryo on day-5 Hum. Reprod. 19 2004 685 693 (Pubitemid 38344536)
3. P. Braude , V. Bolton , and S. Moore Human gene expression first occurs between the four- and eight-cell stages of preimplantation development Nature 332 1988 459 461 (Pubitemid 18090251)
4. J. Cohen , D. Wells , and S. Munné Removal of two cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests employed to enhance implantation rates Fertil. Steril. 87 2007 496 503 (Pubitemid 46389618)
5. P. Colls , T. Escudero , N. Cekleniak , S. Sadowy , J. Cohen , and S. Munné Increased efficiency of preimplantation genetic diagnosis for infertility using 'no result rescue' Fertil. Steril. 88 2007 53 61 (Pubitemid 47001392)
6. C.B. Coulam , R.S. Jeyendram , M. Fiddler , and E. Pergament Discordance among blastomeres renders preimplantation genetic diagnosis for aneuploidy ineffective J. Assist. Reprod. Genet. 24 2007 37 41 (Pubitemid 46213650)
7. A. De Vos , C. Staessen , and M. De Rycke Impact of cleavage-stage embryo biopsy in view of PGD on human blastocyst implantation: a prospective cohort of single embryo transfers Hum. Reprod. 12 2009 2988 2996
8. J.L. Eaton , M.R. Hacker , D. Harris , K.L. Thornton , and A.S. Penzias Assessment of day-3 morphology and euploidy for individual chromosomes in embryos that develop to the blastocyst stage Fertil. Steril. 91 2009 2432 2436
9. Finn, A., Scott, L., Davies, D., Hill, J., in press. Sequential embryo scoring as a predictor of aneuploidy in poor-prognosis patients. Reprod. Biomed. Online, doi: 10.1016/j.rbmo.2010.05.004 .
10. E. Fragouli , D. Wells , and A. Thornhill Comparative genomic hybridization analysis of human oocytes and polar bodies Hum. Reprod. 21 2006 2319 2328 (Pubitemid 44530606)
11. E. Fragouli , M. Katz-Jaffe , and S. Alfarawati Comprehensive chromosome screening of polar bodies and blastocysts from couples experiencing repeated implantation failure Fertil. Steril. 2009 (Epub ahead of print)
12. E. Fragouli , V. Bianchi , and Patrizio Transcriptomic profiling of human oocytes: association of meiotic aneuploidy and altered oocyte gene expression Mol. Hum. Reprod. 2010 (Epub ahead of print)
13. L. Gianaroli , M.C. Magli , and A.P. Ferraretti The beneficial effects of PGD for aneuploidy support extensive clinical application Reprod. BioMed. Online 10 2004 633 640
14. T. Hardarson , G. Caisander , A. Sjögren , C. Hanson , L. Hamberger , and K. Lundin A morphological and chromosomal study of blastocysts developing from morphologically suboptimal human pre-embryos compared with control blastocysts Hum. Reprod. 18 2003 399 407 (Pubitemid 36236277)
15. T. Hardarson , C. Hanson , and K. Lundin Preimplantation genetic screening in women of advanced maternal age caused a decrease in clinical pregnancy rate: a randomized controlled trial Hum. Reprod. 23 2008 2806 2812
16. A. Kuliev , J. Cieslak , Y. Ilkevitch , and Y. Verlinsky Chromosomal abnormalities in a series of 6, 733 human oocytes in preimplantation diagnosis for age-related aneuploidies Reprod. Biomed. Online 6 2003 54 59 (Pubitemid 36857119)
17. M.C. Magli , L. Gianaroli , A.P. Ferraretti , M. Lappi , A. Ruberti , and V. Farfalli Embryo morphology and development are dependent on the chromosome complement Fertil. Steril. 87 2007 534 541 (Pubitemid 46385969)
18. S. Mastenbroek , M. Twisk , and J. van Echten-Arends Preimplantation genetic screening in women of advanced maternal age New Engl. J. Med. 357 2007 9 17
19. S.E. Moayeri , R.B. Allen , W.R. Brewster , M.H. Kim , M. Porto , and L.B. Werlin Day-3 embryo morphology predicts euploidy among older subjects Fertil. Steril. 89 2008 118 123
20. S. Munné , A. Lee , Z. Rosenwaks , J. Grifo , and J. Cohen Diagnosis of major chromosome aneuploidies in human preimplantation embryos Hum. Reprod. 8 1993 2185 2191 (Pubitemid 24012822)
21. S. Munné , M. Sandalinas , and T. Escudero Improved implantation after preimplantation genetic diagnosis of aneuploidy Reprod. Biomed. Online 7 2003 91 97 (Pubitemid 36874416)
22. S. Munné , S. Chen , and P. Colls Maternal age, morphology, development and chromosome abnormalities in over 6000 cleavage-stage embryos Reprod. Biomed. Online 14 2007 628 634 (Pubitemid 46772826)
23. S. Munné , C.M. Howles , and D. Wells The role of preimplantation genetic diagnosis in diagnosing embryo aneuploidy Curr. Opin. Obstet. Gynecol. 21 2009 442 449
24. Munné, S., Wells, D., Cohen, J., in press. Technology requirements for preimplantation genetic diagnosis to improve art outcome. Fertil. Steril.
25. F. Pellestor , B. Andréo , F. Arnal , C. Humeau , and J. Demaille Maternal aging and chromosomal abnormalities: new data drawn from in-vitro unfertilized human oocytes Hum. Genet. 112 2003 195 203 (Pubitemid 36869104)
26. M. Sandalinas , C. Marquez , and S. Munne Spectral karyotyping of fresh, noninseminated oocytes Mol. Hum. Reprod. 8 2002 580 585 (Pubitemid 34746293)
27. W.B. Schoolcraft , E. Fragouli , J. Stevens , S. Munne , M.G. Katz-Jaffe , and D. Wells Clinical application of comprehensive chromosomal screening at the blastocyst stage Fertil. Steril. 2009 (Epub ahead of print)
28. C. Staessen , and A.C. Van Steirteghem The genetic constitution of multinucleated blastomeres and their derivative daughter blastomeres Hum. Reprod. 13 1998 1625 1631 (Pubitemid 28310505)
29. C. Staessen , P. Platteau , and E. Van Assche Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial Hum. Reprod. 19 2004 2849 2858 (Pubitemid 40028958)