Genes, sleep and dreams

Ultradian Rhythms from Molecules to Mind: A New Vision of Life

Volumn , Issue , 2008, Pages 413-429

  Ribeiro, S ^a,b   Simoes C ^a,b   Nicolelis, M ^a,c  

^a Edmond and Lily Safra International Institute for Neuroscience of Natal   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

differential plasticity; Dream; engram; immediate early gene; learning; memory; propagation; REM sleep; reverberation; slow wave sleep

Indexed keywords

EID: 77957823156     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4020-8352-5_17     Document Type: Chapter

References (181)

1. Aserinsky E, Kleitman N (1953) Regularly occurring periods of eye motility, and concomitant phenomena, during sleep. Science 118:273-274.
2. Barrett D (2001) The Committee of Sleep: How Artists, Scientists, and Athletes Use Dreams for Creative Problem-Solving, 1st ed. Edition. New York: Crown Publishers.
3. Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-Term potentiation in the hippocampus. Nature 361:31-39.
4. Born J, Wagner U (2004a) Memory consolidation during sleep: role of cortisol feedback. Ann NY Acad Sci 1032:198-201.
5. Born J, Wagner U (2004b) Awareness in memory: being explicit about the role of sleep. Trends Cogn Sci 8:242-244.
6. Born J, Rasch B, Gais S (2006) Sleep to remember. Neuroscientist 12:410-424.
7. Bozon B, Kelly A, Josselyn SA, Silva AJ, Davis S, Laroche S (2003) MAPK, CREB and zif268 are all required for the consolidation of recognition memory. Philos Trans R Soc Lond B Biol Sci 358:805-814.
8. Braun AR, Balkin TJ, Wesenten NJ, Carson RE, Varga M, Baldwin P, Selbie S, Belenky G, Herscovitch P (1997) Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study. Brain 120:1173-1197.
9. Bryson D, Schacher S (1969) Behavioral analysis of mammalian sleep and learning. Perspect Biol Med 13:71-79.
10. Bushey D, Huber R, Tononi G, Cirelli C (2007) Drosophila Hyperkinetic mutants have reduced sleep and impaired memory. J Neurosci 27:5384-5393.
11. Cantero JL, Atienza M, Madsen JR, Stickgold R (2004) Gamma EEG dynamics in neocortex and hippocampus during human wakefulness and sleep. Neuroimage 22:1271-1280.
12. Cawte J (1984) The ordinary dreams of the Yolngu in Arnhem Land. Aust N Z J Psychiatr 18:236-243.
13. Christy B, Nathans D (1989) DNA binding site of the growth factor-inducible protein Zif268. Proc Natl Acad Sci USA 86:8737-8741.
14. Cirelli C (2006) Sleep disruption, oxidative stress, and aging: new insights from fruit flies. Proc Natl Acad Sci USA 103:13901-13902.
15. Cirelli C, Tononi G (1998) Differences in gene expression between sleep and waking as revealed by mRNA differential display. Brain Res Mol Brain Res 56:293-305.
16. Cirelli C, Tononi G (1999a) Differences in brain gene expression between sleep and waking as revealed by mRNA differential display and cDNA microarray technology. J Sleep Res 8 Suppl 1:44-52.
17. Cirelli C, Tononi G (1999b) Differences in gene expression during sleep and wakefulness. Ann Med 31:117-124.
18. Cirelli C, Tononi G (2000a) Gene expression in the brain across the sleep-waking cycle. Brain Res 885:303-321.
19. Cirelli C, Tononi G (2000b) Differential expression of plasticity-related genes in waking and sleep and their regulation by the noradrenergic system. J Neurosci 20:9187-9194.
20. Cirelli C, Gutierrez CM, Tononi G (2004) Extensive and divergent effects of sleep and wakefulness on brain gene expression. Neuron 41:35-43.
21. Cirelli C, LaVaute TM, Tononi G (2005a) Sleep and wakefulness modulate gene expression in Drosophila. J Neurochem 94:1411-1419.
22. Cirelli C, Faraguna U, Tononi G (2006) Changes in brain gene expression after long-Term sleep deprivation. J Neurochem 98:1632-1645.
23. Cirelli C, Bushey D, Hill S, Huber R, Kreber R, Ganetzky B, Tononi G (2005b) Reduced sleep in Drosophila Shaker mutants. Nature 434:1087-1092.
24. Crick F, Mitchison G (1983) The function of dream sleep. Nature 304:111-114.
25. Crick F, Mitchison G (1995) REM sleep and neural nets. Behav Brain Res 69:147-155.
26. Dave AS, Margoliash D (2000) Song replay during sleep and computational rules for sensorimotor vocal learning. Science 290:812-816.
27. Dement W, Kleitman N (1957a) Cyclic variations in EEG during sleep and their relation to eye movements, body motility, and dreaming. Electroenceph Clin Neurophysiol Suppl 9:673-690.
28. Dement WC (1958) The occurrence of low voltage, fast, electroencephalogram patterns during behavioral sleep in the cat. Electroenceph Clin Neurophysiol 10:291-296.
29. Dement WC, Kleitman N (1957b) The relation of eye movements during sleep to dream activity: an objective method for the study of dreaming. J Exp Psychol 53:339-346.
30. Esposito K, Benitez A, Barza L, Mellman T (1999) Evaluation of dream content in combat-related PTSD. J Trauma Stress 12:681-687.
31. Fishbein W (1971) Disruptive effects of rapid eye movement sleep deprivation on long-Term memory. Physiol Behav 6:279-282.
32. Fishbein W, Gutwein BM (1977) Paradoxical sleep and memory storage processes. Behav Biol 19:425-464.
33. Fishbein W, Schaumburg H, Weitzman ED (1966) Rapid eye movements during sleep in darkreared kittens. J Nerv Ment Dis 143:281-283.
34. Fishbein W, McGaugh JL, Swarz JR (1971) Retrograde amnesia: electroconvulsive shock effects after termination of rapid eye movement sleep deprivation. Science 172:80-82.
35. Fishbein W, Kastaniotis C, Chattman D (1974) Paradoxical sleep: prolonged augmentation following learning. Brain Res 79:61-75.
36. Flanagan O (2000) Dreaming is not an adaptation. Behavioral & Brain Sciences 23:936-939.
37. Fosse R, Stickgold R, Hobson JA (2001) The mind in REM sleep: reports of emotional experience. Sleep 24:947-955.
38. Fosse R, Stickgold R, Hobson JA (2004) Thinking and hallucinating: reciprocal changes in sleep. Psychophysiology 41:298-305.
39. Fosshage JL, Loew CA (1978) Dream Interpretation: A Comparative Study. New York: SP Medical & Scientific Books.
40. Frankland PW, OBrien C, Ohno M, Kirkwood A, Silva AJ (2001) Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memory. Nature 411:309-313.
41. Freud S (1900) The Interpretation of Dreams, 1952 Edition. London: Encyclopaedia Britannica.
42. Freud S (1915) The Unconscious, Republished in 1952 Edition. London: Encyclopaedia Britannica.
43. Freud S (1920) Beyond the Pleasure Principle. New York: W. W. Norton.
44. Ganguly-Fitzgerald I, Donlea J, Shaw PJ (2006) Waking experience affects sleep need in Drosophila. Science 313:1775-1781.
45. Gervasoni D, Lin SC, Ribeiro S, Soares ES, Pantoja P, Nicolelis M (2004) Global forebrain dynamics predict rat behavioral states and their transitions. J Neurosci 24:11137-11147.
46. Giuditta A, ed (1985) A Sequential Hypothesis for the Function of Sleep. Stuttgart: Fisher-Verlag.
47. Grastyan E, Karmos G (1961) A study of a possible dreaming mechanism in the cat. Acta Physiol Acad Sci Hung 20:41-50.
48. Gutwein BM, Shiromani PJ, Fishbein W (1980) Paradoxical sleep and memory: long-Term disruptive effects of Anisomycin. Pharmacol Biochem Behav 12:377-384.
49. Guzowski JF, Lyford GL, Stevenson GD, Houston FP, McGaugh JL, Worley PF, Barnes CA (2000) Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-Term potentiation and the consolidation of long-Term memory. J Neurosci 20:3993-4001.
50. Hartmann E (1967) The Biology of Dreaming. Springfield, IL: Charles Thomas.
51. Hartmann E (1998) Dreams and Nightmares: The New Theory on the origin and Meaning of Dreams. New York: Plenum.
52. Hennevin E, Leconte P (1977) [Study of the relations between paradoxical sleep and learning processes (authors transl)]. [French]. Physiol Behav 18:307-319.
53. Hennevin E, Hars B, eds (1985) Post-learning Paradoxical Sleep: a Critical Period When New Memory Is Reactivated. New York: Plenum.
54. Hennevin E, Hars B (1992) 2nd-order conditioning during sleep. Psychobiology 20:166-176.
55. Hennevin E, Hars B, Bloch V (1989) Improvement of learning by mesencephalic reticular stimulation during postlearning paradoxical sleep. Behav Neural Biol 51:291-306.
56. Hennevin E, Hars B, Maho C (1995a) Memory processing in paradoxical sleep. Sleep Res Soc Bull 1:44-50.
57. Hennevin E, Maho C, Hars B, Dutrieux G (1993) Learning-induced plasticity in the medial geniculate nucleus is expressed during paradoxical sleep. Behav Neurosci 107:1018-1030.
58. Hennevin E, Hars B, Maho C, Bloch V (1995b) Processing of learned information in paradoxical sleep: relevance for memory. Behav Brain Res 69:125-135.
59. Hilfiker S, Pieribone VA, Czernik AJ, Kao HT, Augustine GJ, Greengard P (1999) Synapsins as regulators of neurotransmitter release. Philos Trans R Soc Lond B Biol Sci 354:269-279.
60. Hirase H, Leinekugel X, Czurko A, Csicsvari J, Buzsaki G (2001) Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. Proc Natl Acad Sci USA 98:9386-9390.
61. Hoffman KL, McNaughton B (2002) Coordinated reactivation of distributed memory traces in primate neocortex. Science 297:2070-2073.
62. Horstmanshoff HF (2004) Asclepius and temple medicine in aelius Aristides Sacred Tales. Stud Anc Med 27:325-341.
63. Huber R, Hill SL, Holladay C, Biesiadecki M, Tononi G, Cirelli C (2004) Sleep homeostasis in Drosophila melanogaster. Sleep 27:628-639.
64. Jenkins JB, Dallenbach KM (1924) Oblivescence during sleep and waking. Am J of Psychology 35:605-612.
65. Jouvet M (1967) The states of sleep. Sci Am 216:62-68.
66. Jouvet M (1994) Paradoxical sleep mechanisms. Sleep 17:S77-S83.
67. Jouvet M, Delorme F (1965) Locus coeruleus et sommeil paradoxal. CR Soc Biol (Paris) 159:895-899.
68. Jouvet M, Michel F, Courjon J (1959) Sur un stade dactivit lectrique crbrale rapide au cours du sommeil physiologique. CR Soc Biol (Paris) 153:1024-1028.
69. Jung CG (1953a) General Aspects of Dream Psychology. In: Collected Works, pp 237-280. Princeton, NJ: Princeton University Press.
70. Jung CG (1953b) On the nature of Dreams. In, pp 281-297. Princeton, NJ: Princeton University Press.
71. Jung CG (1974) Dreams, 1st Edition. Princeton, NJ: Princeton University Press.
72. Jung CG, Von Franz ML, Henderson J (1969) Man and His Symbols. New York: Doubleday.
73. Jung-Beeman M, Bowden EM, Haberman J, Frymiare JL, Arambel-Liu S, Greenblatt R, Reber PJ, Kounios J (2004) Neural activity when people solve verbal problems with insight. PLoS Biol 2:500-510.
74. Kales A, Hoedemaker FS, Jacobson A, Kales JD, Paulson MJ, Wilson TE (1967) Mentation during sleep: REM and NREM recall reports. Percept Mot Skills 24:555-560.
75. Karni A, Tanne D, Rubenstein BS, Askenasy JJ, Sagi D (1994) Dependence on REM sleep of overnight improvement of a perceptual skill. Science 265:679-682.
76. Kilton S (1951) Dream theory in Malaya. Complex 6:21-33.
77. Kleitman N (1963) Sleep and Wakefulness. Chicago, IL: University of Chicago Press.
78. Kohler W (1947) Gestalt Psychology: An Introduction to New Concepts in Modern Psychology, Reissue Edition. New York: Liveright.
79. Kuhn TS (1962) The Structure of Scientific Revolutions. Chicago, IL: University of Chicago Press.
80. Leconte P, Bloch V (1970) Dficit de la rtention dun conditionnement aprs privation de sommeil paradoxal chez le rat. Comptes Rendus de lAcadmie des Sciences (Paris) 271D:226-229.
81. Leconte P, Hennevin E (1971) Augmentation de la dure de sommeil paradoxal conscutive un apprentissage chez le rat. C R Acad Sci (Paris) 273:86-88.
82. Leconte P, Hennevin E (1973) [Temporal characteristics of the augmentation of paradoxal sleep following learning in the rat]. [French]. Physiol Behav 11:677-686.
83. Leconte P, Hennevin E, Bloch V (1973) Analyse des effets dun apprentissage et de son niveau dacquisition sur le sommeil paradoxal conscutif. Brain Res 49:367-379.
84. Leconte P, Hennevin E, Bloch V (1974) Duration of paradoxical sleep necessary for the acquisition of conditioned avoidance in the rat. Physiol Behav 13:675-681.
85. Lee AK, Wilson MA (2002) Memory of sequential experience in the hippocampus during slow wave sleep. Neuron 36:1183-1194.
86. Lee MG, Jones BE (2004) Role of basalo-cortical system in modulating cortical activity and sleep-wake states. In: Sleep: Circuits & Functions (Luppi P-H, ed). New York: CRC.
87. Lincoln JS (2003) The Dream in Native American and Other Primitive Cultures. New York: Dover Publications.
88. Lisman J, Schulman H, Cline H (2002) The molecular basis of CaMKII function in synaptic and behavioural memory. Nat Rev Neurosci 3:175-190.
89. Louie K, Wilson MA (2001) Temporally structured replay of awake hippocampal ensemble activity during rapid eye movement sleep. Neuron 29:145-156.
90. Lucero MA (1970) Lengthening of REM sleep duration consecutive to learning in the rat. Brain Res 20:319-322.
91. Luppi P-H, Boissard R, Gervasoni D, Verret L, Goutagny R, Peyron C, Salvert D, Lger L, Barbagli B, Fort P (2004) The network responsible for paradoxical sleep onset and maintenance: a new theory based on the head-restrained rat model. In: Sleep: Circuits & Functions (Luppi P-H, ed). New York: CRC.
92. Lyford GL, Yamagata K, Kaufmann WE, Barnes CA, Sanders LK, Copeland NG, Gilbert DJ, Jenkins NA, Lanahan AA, Worley PF (1995) Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-Associated protein that is enriched in neuronal dendrites. Neuron 145:433-434.
93. Maquet P (1996) [Paradoxical human sleep]. Rev Med Liege 51:632.
94. Maquet P (2001) The role of sleep in learning and memory. Science 294:1048-1052.
95. Maquet P, Phillips C (1998) Functional brain imaging of human sleep. J Sleep Res 7:42-47.
96. Maquet P, Peters J, Aerts J, Delfiore G, Degueldre C, Luxen A, Franck G (1996) Functional neuroanatomy of human rapid-eye-movement sleep and dreaming. Nature 383:163-166.
97. Maquet P, Degueldre C, Delfiore G, Aerts J, Peters JM, Luxen A, Franck G (1997) Functional neuroanatomy of human slow wave sleep. J Neurosci 17:2807-2812.
98. Maquet P, Laureys S, Peigneux P, Fuchs S, Petiau C, Phillips C, Aerts J, Del Fiore G, Degueldre C, Meulemans T, Luxen A, Franck G, Van Der Linden M, Smith C, Cleeremans A (2000) Experience-dependent changes in cerebral activation during human REM sleep. Nat Neurosci 3:831-836.
99. McGaugh JL (2000) Memory-A century of consolidation. Science 287:248-251.
100. Mednick SC, Nakayama K, Stickgold R (2003) Sleep-dependent learning: a nap is as good as a night. Nat Neurosci 6:697-698.
101. Mednick SC, Nakayama K, Cantero JL, Atienza M, Levin AA, Pathak N, Stickgold R (2002) The restorative effect of naps on perceptual deterioration. Nat Neurosci 5:677-681.
102. Meier CA (2003) Healing Dream and Ritual: Ancient Incubation and Modern Psychotherapy. Einsiedeln, Switzerland: Daimon Verlag.
103. Milbrandt J (1987) A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science 238:797-799.
104. Miller PC (1997) Dreams in Late Antiquity. Princeton, NJ: Princeton University Press.
105. Muzur A, Pace-Schott EF, Hobson JA (2002) The prefrontal cortex in sleep. Trends Cogn Sci 6:475-481.
106. Nadasdy Z, Hirase H, Czurko A, Csicsvari J, Buzsaki G (1999) Replay and time compression of recurring spike sequences in the hippocampus. J Neurosci 19:9497-9507.
107. Neylan TC, Marmar CR, Metzler TJ, Weiss DS, Zatzick DF, Delucchi KL, Wu RM, Schoenfeld FB (1998) Sleep disturbances in the Vietnam generation: findings from a nationally representative sample of male Vietnam veterans. Am J Psychiatr 155:929-933.
108. Nofzinger EA, Mintun MA, Wiseman M, Kupfer DJ, Moore RY (1997) Forebrain activation in REM sleep: an FDG PET study. Brain Res 770:192-201.
109. OHara BF, Young KA, Watson FL, Heller HC, Kilduff TS (1993) Immediate early gene expression in brain during sleep deprivation: preliminary observations. Sleep 16:1-7.
110. Pavlides C, Winson J (1989) Influences of hippocampal place cell firing in the awake state on the activity of these cells during subsequent sleep episodes. J Neurosci 9:2907-2918.
111. Pearlman CA (1969) Effect of rapid eye movement (dreaming) sleep deprivation on retention of avoidance learning in rats. Report US Naval Submarine Medical Center 22:1-4.
112. Peigneux P, Laureys S, Fuchs S, Destrebecqz A, Collette F, Delbeuck X, Phillips C, Aerts J, Del Fiore G, Degueldre C, Luxen A, Cleeremans A, Maquet P (2003) Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep. Neuroimage 20:125-134.
113. Peirce CS (1958) Collected Papers of Charles Sanders Peirce. Cambridge, MA: Harvard University Press.
114. Pereira A, Ribeiro S, Wiest M, Moore LC, Pantoja J, Lin SC, Nicolelis MA (2007) Processing of tactile information by the hippocampus. Proc Natl Acad Sci USA 104:18286-18291.
115. Petersohn D, Schoch S, Brinkmann DR, Thiel G (1995) The human synapsin II gene promoter. Possible role for the transcription factor zif268/egr-1, polyoma enhancer activator 3, and AP2. J Biol Chem 270:24361-24369.
116. Pompeiano M, Cirelli C, Tononi G (1994) Immediate-early genes in spontaneous wakefulness and sleep: expression of c-fos and NGIF-A mRNA protein. J Sleep Res 3:80-96.
117. Popper K (1963) Conjectures and Refutations: The Growth of Scientific Knowledge. London: Routledge.
118. Qin YL, McNaughton BL, Skaggs WE, Barnes CA (1997) Memory reprocessing in corticocortical and hippocampocortical neuronal ensembles. Philos Trans R Soc Lond B Biol Sci 352:1525-1533.
119. Rechtschaffen A, Kales A (1968) A manual of standardized terminology, techniques and scoring system for sleep stages in human subjects. Washington, DC: National Institutes of Health.
120. Revonsuo A (2000) The reinterpretation of dreams: an evolutionary hypothesis of the function of dreaming. Behav Brain Sci 23:877-901.
121. Ribeiro S, Nicolelis MAL (2004) Reverberation, storage and postsynaptic propagation of memories during sleep. Learn Mem 11:686-696.
122. Ribeiro S, Nicolelis M (2006) The evolution of neural systems for sleep and dreaming. In: Evolution of Nervous Systems (Kaas J, ed), pp 451-464. New York: Elsevier.
123. Ribeiro S, Goyal V, Mello CV, Pavlides C (1999) Brain gene expression during REM sleep depends on prior waking experience. Learn Mem 6:500-508.
124. Ribeiro S, Mello CV, Velho T, Gardner TJ, Jarvis ED, Pavlides C (2002) Induction of hippocampal long-Term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye- movement sleep. J Neurosci 22:10914-10923.
125. Ribeiro S, Gervasoni D, Soares ES, Zhou Y, Lin SC, Pantoja P, Lavine M, Nicolelis M (2004a) Long-lasting novelty-induced neuronal reverberation during slow-wave sleep in multiple forebrain areas. PLoS Biology 2:126-137.
126. Ribeiro S, Pereira A, Ross J, Gao Z, Lin S-C, Gervasoni D, Marriott P, Lavine M, Nicolelis MAL (2004b) REM sleep is a noisy mode of offline neuronal processing. In: 34th Meeting of the Society for Neuroscience, p 324.310. San Diego, CA: Society for Neuroscience.
127. Ribeiro S, Xinwu S, Engelhard M, Zhou Y, Zhang H, Gervasoni D, Lin SC, Wada K, Lemos NAM, Nicolelis MAL (2007) Novel experience induces persistent sleep-dependent plasticity in the cortex but not in the hippocampus. Frontiers in Neuroscience 1:43-55.
128. Roffwarg HP, Dement WC, Muzio JN, Fisher C (1962) Dream imagery: relationship to rapid eye movements of sleep. Arch Gen Psychiatry 7:235-258.
129. Ross RJ, Ball WA, Dinges DF, Kribbs NB, Morrison AR, Silver SM, Mulvaney FD (1994) Rapid eye movement sleep disturbance in posttraumatic stress disorder. Biol Psychiatry 35:195-202.
130. Ross RJ, Ball WA, Sanford LD, Morrison AR, Dinges DF, Silver SM, Kribbs NB, Mulvaney FD, Gehrman PR, McGinnis DE (1999) Rapid eye movement sleep changes during the adaptation night in combat veterans with posttraumatic stress disorder. Biol Psychiatry 45:938-941.
131. Schreuder BJ, van Egmond M, Kleijn WC, Visser AT (1998) Daily reports of posttraumatic nightmares and anxiety dreams in Dutch war victims. J Anxiety Disord 12:511-524.
132. Schultz W (2002) Getting formal with dopamine and reward. Neuron 36:241-263.
133. Shaw PJ, Cirelli C, Greenspan RJ, Tononi G (2000) Correlates of sleep and waking in Drosophila melanogaster. Science 287:1834-1837.
134. Shulman D, Stroumsa GG, Stroumsa GAG (1999) Dream Cultures: Explorations in the Comparative History of Dreaming. Oxford: Oxford University Press.
135. Siegel JM (1990) Mechanisms of sleep control. J Clin Neurophysiol 7:49-65.
136. Siegel JM (2001) The REM sleep-memory consolidation hypothesis. Science 294:1058-1063.
137. Skaggs WE, McNaughton BL (1996) Replay of neuronal firing sequences in rat hippocampus during sleep following spatial experience. Science 271:1870-1873.
138. Smith C (1995) Sleep states and memory processes. Behav Brain Res 69:137-145.
139. Smith C (1996) Sleep states, memory processes and synaptic plasticity. Behav Brain Res 78:49-56.
140. Smith C (2001) Sleep states and memory processes in humans: procedural versus declarative memory systems. Sleep Med Rev 5:491-506.
141. Smith C, Butler S (1982) Paradoxical sleep at selective times following training is necessary for learning. Physiol Behav 29:469-473.
142. Smith C, Lapp L (1986) Prolonged increases in both PS and number of REMS following a shuttle avoidance task. Physiol Behav 36:1053-1057.
143. Smith C, Kelly G (1988) Paradoxical sleep deprivation applied two days after end of training retards learning. Physiol Behav 43:213-216.
144. Smith C, Wong PTP (1991) Paradoxical sleep increases predict successful learning in a complex operant task. Behav Neurosci 105:282-288.
145. Smith C, Lapp L (1991) Increases in number of REMS and REM density in humans following an intensive learning period. Sleep 14:325-330.
146. Smith C, MacNeill C (1993) A paradoxical sleep-dependent window for memory 53-56-H after the end of avoidance training. Psychobiology 21:109-112.
147. Smith C, Young J, Young W (1980) Prolonged increases in paradoxical sleep during and after avoidance-Task acquisition. Sleep 3:67-68.
148. Smith C, Kitahama K, Valatx JL, Jouvet M (1974) Increased paradoxical sleep in mice during acquisition of a shock avoidance task. Brain Res 77:221-230.
149. Solms M (1997) The Neuropsychology of Dreams. New York: Lawrence Erlbaum.
150. Solms M (2000) Dreaming and REM sleep are controlled by different brain mechanisms. Behav Brain Sci 23:843-850.
151. Solms M (2004) Freud returns. Sci Am 290:82-88.
152. Steriade M (1992) Basic mechanisms of sleep generation. Neurology 42:9-18.
153. Steriade M, McCormick DA, Sejnowski TJ (1993) Thalamocortical oscillations in the sleeping and aroused brain. Science 262:679-685.
154. Steward O, Wallace CS, Lyford GL, Worley PF (1998) Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites. Neuron 21:741-751.
155. Stickgold R (1998) Sleep: off-line memory reprocessing. Trends Cogn Sci 2:484-492.
156. Stickgold R (2001) Toward a cognitive neuroscience of sleep. Sleep Med Rev 5:417-421.
157. Stickgold R (2003) Memory, cognition, and dreams. In: Sleep and Brain Plasticity (P. Maquet CS, R. Stickgold, ed), pp 17-39. Oxford: Oxford University Press.
158. Stickgold R, Walker MP (2005) Memory consolidation and reconsolidation: what is the role of sleep? Trends Neurosci 28:408-415.
159. Stickgold R, James L, Hobson JA (2000a) Visual discrimination learning requires sleep after training. Nat Neurosci 3:1237-1238.
160. Stickgold R, Fosse R, Walker MP (2002) Linking brain and behavior in sleep-dependent learning and memory consolidation. Proc Natl Acad Sci USA 99:16519-16521.
161. Stickgold R, Scott L, Rittenhouse C, Hobson JA (1999) Sleep-induced changes in associative memory. J Cogn Neurosci 11:182-193.
162. Stickgold R, Hobson JA, Fosse R, Fosse M (2001) Sleep, learning, and dreams: off-line memory reprocessing. Science 294:1052-1057.
163. Stickgold R, Whidbee D, Schirmer B, Patel V, Hobson JA (2000b) Visual discrimination task improvement: a multi-step process occurring during sleep. J Cogn Neurosci 12:246-254.
164. Sutcliffe JG, de Lecea L (2002) The hypocretins: setting the arousal threshold. Nat Rev Neurosci 3:339-349.
165. Tanji J, Hoshi E (2001) Behavioral planning in the prefrontal cortex. Curr Opin Neurobiol 11:164-170.
166. Thiel G, Schoch S, Petersohn D (1994) Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1. J Biol Chem 269:15294-15301.
167. Timo-Iaria C, Negrao N, Schmidek WR, Hoshino K, Lobato de Menezes CE, Leme da Rocha T (1970) Phases and states of sleep in the rat. Physiol Behav 5:1057-1062.
168. Tononi G, Cirelli C (2003) Sleep and synaptic homeostasis: a hypothesis. Brain Res Bull 62:143-150.
169. Tononi G, Cirelli C, Pompeiano M (1995) Changes in gene expression during the sleep-waking cycle: a new view of activating systems. Arch Ital Biol 134:21-37.
170. Ulloor J, Datta S (2005) Spatio-Temporal activation of cyclic AMP response element-binding protein, activity-regulated cytoskeletal-Associated protein and brain-derived nerve growth factor: a mechanism for pontine-wave generator activation-dependent two-way active-Avoidance memory processing in the rat. J Neurochem 95:418-428.
171. Vyazovskiy V, Cirelli C, Pfister-Genskow M, Faraguna U, Tononi G (2008) Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep. Nat Neurosci 11:200-208.
172. Wagner U, Gais S, Haider H, Verleger R, Born J (2004) Sleep inspires insight. Nature 427:352-355.
173. Walker MP, Stickgold R (2004) Sleep-dependent learning and memory consolidation. Neuron 44:121-133.
174. Walker MP, Liston C, Hobson JA, Stickgold R (2002a) Cognitive flexibility across the sleep-wake cycle: REM-sleep enhancement of anagram problem solving. Brain Res Cogn Brain Res 14:317-324.
175. Walker MP, Brakefield T, Morgan A, Hobson JA, Stickgold R (2002b) Practice with sleep makes perfect: sleep-dependent motor skill learning. Neuron 35:205-211.
176. Walker MP, Brakefield T, Seidman J, Morgan A, Hobson JA, Stickgold R (2003) Sleep and the time course of motor skill learning. Learn Mem 10:275-284.
177. Waltereit R, Dammermann B, Wulff P, Scafidi J, Staubli U, Kauselmann G, Bundman M, Kuhl D (2001) Arg3.1/Arc mRNA induction by Ca2 + and cAMP requires protein kinase A and mitogen-Activated protein kinase/extracellular regulated kinase activation. J Neurosci 21:5484-5493.
178. Wilson MA, McNaughton BL (1994) Reactivation of hippocampal ensemble memories during sleep. Science 265:676-679.
179. Winson J (1985) Brain and Psyche. New York: Anchor.
180. Winson J, Abzug C (1977) Gating of neuronal transmission in the hippocampus: efficacy of transmission varies with behavioral state. Science 196:1223-1225.
181. Wisden W, Errington ML, Williams S, Dunnett SB, Waters C, Hitchcock D, Evan G, Bliss TV, Hunt SP (1990) Differential expression of immediate early genes in the hippocampus and spinal cord. Neuron 4:603-614