Association between intratumoral lymphatic microvessel density (LMVD) and clinicopathologic features in endometrial cancer: A retrospective cohort study

World Journal of Surgical Oncology

Volumn 8, Issue , 2010, Pages

  Kawamura, Lecy ^a   Carvalho, Filomena M ^a   Alves, Bernardo G L ^a   Bacchi, Carlos E ^b   Goes, Joao C S ^c   Calil, Marcelo A ^c   Baracat, Edmund C ^a   Carvalho, Jesus P ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Department of Pathology of Faculdade de Medicina da Universidade de São Paulo ^*  (Brazil)

^c Instituto Brasileiro de Controle do Cancer   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

PODOPLANIN;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CELL DENSITY; CELL INFILTRATION; CLINICAL FEATURE; DISEASE ASSOCIATION; ENDOMETRIUM CANCER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH VESSEL; LYMPHANGIOGENESIS; LYMPHATIC MICROVESSEL DENSITY; MAJOR CLINICAL STUDY; MICROVASCULATURE; PROGNOSIS; PROTEIN EXPRESSION; SURVIVAL; BRAZIL; COMPARATIVE STUDY; DISEASE COURSE; ENDOMETRIUM TUMOR; FEMALE; FOLLOW UP; METASTASIS; METHODOLOGY; MIDDLE AGED; MORTALITY; PATHOLOGY; RETROSPECTIVE STUDY; SURVIVAL RATE;

AGED; BRAZIL; DISEASE PROGRESSION; ENDOMETRIAL NEOPLASMS; FEMALE; FOLLOW-UP STUDIES; HUMANS; LYMPHANGIOGENESIS; LYMPHATIC METASTASIS; LYMPHATIC VESSELS; MICROVESSELS; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 77957818070     PISSN: None     EISSN: 14777819     Source Type: Journal    
DOI: 10.1186/1477-7819-8-89     Document Type: Article

References (25)

1. Sorosky JI. Endometrial cancer. Obstet Gynecol 2008, 111:436-447.
2. Mariani A, Webb MJ, Keeney GL, Aletti G, Podratz KC. Predictors of lymphatic failure in endometrial cancer. Gynecol Oncol 2002, 84:437-442.
3. Prat J. Prognostic parameters of endometrial carcinoma. Hum Pathol 2004, 35:649-662.
4. Hoekstra AV, Kim RJ, Small W, Rademaker AW, Helenowski IB, Singh DK, Schink JC, Lurain JR. FIGO stage IIIC endometrial carcinoma: prognostic factors and outcomes. Gynecol Oncol 2009, 114:273-278.
5. Van der Auwera I, Cao Y, Tille JC, Pepper MS, Jackson DG, Fox SB, Harris AL, Dirix LY, Vermeulen PB. First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours. Br J Cancer 2006, 95:1611-1625. 2360768, 17117184.
6. Cao Y. Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis. Nat Rev Cancer 2005, 5:735-743.
7. Liersch R, Biermann C, Mesters RM, Berdel WE. Lymphangiogenesis in cancer: current perspectives. Recent Results Cancer Res 2010, 180:115-135.
8. Zhang SQ, Yu H, Zhang LL. Clinical implications of increased lymph vessel density in the lymphatic metastasis of early-stage invasive cervical carcinoma: a clinical immunohistochemical method study. BMC Cancer 2009, 9:64. 2650709, 19232130.
9. Gombos Z, Xu X, Chu CS, Zhang PJ, Acs G. Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix. Clin Cancer Res 2005, 11:8364-8371.
10. Birner P, Schindl M, Obermair A, Breitenecker G, Kowalski H, Oberhuber G. Lymphatic microvessel density as a novel prognostic factor in early-stage invasive cervical cancer. Int J Cancer 2001, 95:29-33.
11. Vandenput I, Vanhove T, Calster BV, Gorp TV, Moerman P, Verbist G, Vergote I, Amant F. The use of lymph vessel markers to predict endometrial cancer outcome. Int J Gynecol Cancer 2010, 20:363-367.
12. Stefansson IM, Salvesen HB, Akslen LA. Vascular proliferation is important for clinical progress of endometrial cancer. Cancer Res 2006, 66:3303-3309.
13. Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet 2009, 105:103-104.
14. Tavassoli FA, Deville A. Pathology & Genetics Tumours of Breast and Female Genital Organs 2003, Lion: International Agency for Research on Cancer - IARC Press.
15. Alkushi A, Abdul-Rahman ZH, Lim P, Schulzer M, Coldman A, Kalloger SE, Miller D, Gilks CB. Description of a novel system for grading of endometrial carcinoma and comparison with existing grading systems. Am J Surg Pathol 2005, 29:295-304.
16. Hall FT, Freeman JL, Asa SL, Jackson DG, Beasley NJ. Intratumoral lymphatics and lymph node metastases in papillary thyroid carcinoma. Arch Otolaryngol Head Neck Surg 2003, 129:716-719.
17. Epi Info. 2008, Atlanta, GA: Centers for Disease Control and Prevention (CDC), 3.5.1.
18. Alitalo K, Tammela T, Petrova TV. Lymphangiogenesis in development and human disease. Nature 2005, 438:946-953.
19. He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S, Harding T, Jooss K, Takahashi T, Alitalo K. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 2005, 65:4739-4746.
20. Stacker SA, Achen MG, Jussila L, Baldwin ME, Alitalo K. Lymphangiogenesis and cancer metastasis. Nat Rev Cancer 2002, 2:573-583.
21. Sundar SS, Ganesan TS. Role of lymphangiogenesis in cancer. J Clin Oncol 2007, 25:4298-4307.
22. Gao Y, Liu Z, Gao F, Meng XY. High density of peritumoral lymphatic vessels is a potential prognostic marker of endometrial carcinoma: a clinical immunohistochemical method study. BMC Cancer 2010, 10:131. 2858111, 20374665.
23. Donoghue JF, Lederman FL, Susil BJ, Rogers PA. Lymphangiogenesis of normal endometrium and endometrial adenocarcinoma. Hum Reprod 2007, 22:1705-1713.
24. Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 2002, 296:1883-1886.
25. Szuba A, Skobe M, Karkkainen MJ, Shin WS, Beynet DP, Rockson NB, Dakhil N, Spilman S, Goris ML, Strauss HW, Quertermous T, Alitalo K, Rockson SG. Therapeutic lymphangiogenesis with human recombinant VEGF-C. FASEB J 2002, 16:1985-1987.