An aqueous extract of Poncirus fructus activates the prokinetic activity of 5-HT receptor subtype 4 without hERG interaction

Journal of Ethnopharmacology

Volumn 132, Issue 1, 2010, Pages 328-333

  Shim, Won Sik ^a   Back, Heejung ^a   Jung, Sang Won ^a   Kim, Jun Woo ^b   Jang, Yongwoo ^a   Lee, Byeongjun ^a   Seo, Eun Kyoung ^c   Oh, Uhtaek ^a   Shim, Chang Koo ^a  

^a Seoul National University   (South Korea)

^b LG Chemical Ltd   (South Korea)

^c Ewha Womans University   (South Korea)

Author keywords

5 HT4; HERG; Intestine; Motility; Poncirus fructus; Prokinetic

Indexed keywords

5 FLUORO 2 METHOXY 1H INDOLE 3 CARBOXYLIC ACID 1 [2 (METHYLSULFONAMIDO)ETHYL] 4 PIPERIDINYLMETHYL ESTER; ASTEMIZOLE; CISAPRIDE; CYCLIC AMP; PLANT EXTRACT; PONCIRUS FRUCTUS EXTRACT; POTASSIUM CHANNEL HERG; SEROTONIN 4 RECEPTOR; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; ELECTROPHYSIOLOGY; FRUIT; GASTROINTESTINAL TRANSIT; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; TRIFOLIATE ORANGE;

ANIMALS; ASTEMIZOLE; CELL LINE; CELL MEMBRANE; CYCLIC AMP; ETHER-A-GO-GO POTASSIUM CHANNELS; FRUIT; GASTROINTESTINAL TRANSIT; HUMANS; PATCH-CLAMP TECHNIQUES; PLANT EXTRACTS; PONCIRUS; POTASSIUM CHANNEL BLOCKERS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN 5-HT4 RECEPTOR AGONISTS; SEROTONIN 5-HT4 RECEPTOR ANTAGONISTS; TRANSFECTION;

PONCIRUS; PONCIRUS TRIFOLIATA; RATTUS; RUTACEAE;

EID: 77957798837     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.08.042     Document Type: Article

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