Ecopharmacovigilance for better health

Drug Safety

Volumn 33, Issue 11, 2010, Pages 963-968

  Velo, Giampaolo ^a   Moretti, Ugo ^a  

^a UNIVERSITY HOSPITAL OF VERONA   (Italy)

Author keywords

Environmental pollution; Pharmacovigilance

Indexed keywords

17ALPHA ESTRADIOL; ACETYLSALICYLIC ACID; ANALGESIC AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CHLORAMPHENICOL; DICLOFENAC; ERYTHROMYCIN; ESTRADIOL; ETHINYLESTRADIOL; HORMONE DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IBUPROFEN; INDOMETACIN; KETOPROFEN; LINCOMYCIN; MESTRANOL; NAPROXEN; NORETHISTERONE; PHENAZONE; PROGESTERONE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; ROXITHROMYCIN; SULFONAMIDE; TESTOSTERONE; TETRACYCLINE DERIVATIVE; TRIMETHOPRIM; UNINDEXED DRUG;

DRUG SURVEILLANCE PROGRAM; EDITORIAL; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; HUMAN; NONHUMAN; PRIORITY JOURNAL; WATER CONTAMINATION;

ANIMALS; BIOLOGICAL PRODUCTS; DRINKING; DRUG TOXICITY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; HEALTH STATUS INDICATORS; HUMANS; MALE; PHARMACEUTICAL PREPARATIONS; RISK MANAGEMENT; WATER SUPPLY;

EID: 77957786805     PISSN: 01145916     EISSN: 11791942     Source Type: Journal    
DOI: 10.2165/11539380-000000000-00000     Document Type: Editorial

References (33)

1. Gore A. Moving beyond Kyoto. The New York Times 2007 Jul 1 [online]. Available from URL: http://www.nytimes.com/2007/07/01/opinion/01gore.html [Accessed 2010 Jun 16]
2. Edwards IR, Hugman B, Lindquist M, et al. Erice Statement 2009: communication, medicines and patient safety. Br J Clin Pharmacol 2010; 69 (2): 207-8
3. Wise R. Antimicrobial resistance: priorities for action. Antimicrob Chemother 2002; 49: 585-6
4. Ternes T, Giger W, Joss A. Introduction in human phar-maceuticals, hormones and fragrances. In: Ternes T, Joss A, editors. The challenge of micropollutants in urban water management. IWA Publishing, 2007: 1-14
5. Kuhler TC, Andersson M, Carlin G, et al. Do biological medicinal products pose a risk to the environment? A current view on ecopharmacovigilance. Drug Saf 2009; 32 (11): 995-1000
6. Tysklind M, Fick J, Kallenborn R. The spread of drugs in soil and water. In: Collaboration between Apoteket AB, Stockholm County Council and Stockholm University. Environment and pharmaceuticals. Apoteket AB, 2006: 41-53 [online]. Available from URL: http://www.janusinfo. se/imcms/servlet/GetDoc?meta-id=9564 [Accessed 2010 Jun 16]
7. Kummerer K. Pharmaceuticals in the environment. 3rd ed. Berlin, Heidelberg: Springer-Verlag, 2008
8. Kummerer K. Resistance in the environment. J Antimicrob Chemother 2004; 54: 311-20
9. D'Costa VM, McGrann KM, Hughes DW, et al. Sampling in the antibiotic resistome. Science 2006; 311: 374-7
10. Zuccato E, Calamari D, Natangelo M, et al. Presence of therapeutic drugs in the environment. Lancet 2000; 355: 1789-90
11. Zuccato E, Chiabrando C, Castiglioni S, et al. Cocaine in surface waters: a new evidence-based tool to monitor community drug abuse. Environ Health 2005 Aug 5; 4: 14-20
12. Heberer T. Occurrence, fate, and removal of pharmaceuti-cals residues in the aquatic environment: a review of recent research data. Toxicol Lett 2002; 131: 5-17
13. Kolpin DW, Furlong ET, Meyer MT, et al. Pharmaceuticals, hormones and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environ Sci Technol 2002; 36: 1202-11
14. Dove A. Drugs down the drain. Nat Med 2006; 12 (4): 376-7
15. Stan H, Heberer T, Linkerhagner M. Occurrence of clofibric acid in the aquatic system: is the use in human medical care the source of the contamination of surface, ground, and drinking water? Vom Wasser 1994; D 83: 57-68
16. Ternes TA. Analytical methods for the determination of pharmaceuticals in aqueous environmental samples. Trends Anal Chem 2001; 20: 419-33
17. Ye Z, Weinberg HS, Meyer MT. Trace analysis of tri-methoprim and sulfonamide, macrolide, quinolone, and tetracycline antibiotics in chlorinated drinking water using liquid chromatography electrospray tandem mass spectro-metry. Anal Chem 2007; 79 (3): 1135-44
18. Jones OA, Lester JN, Voulvonis N. Pharmaceuticals: a threat to drinking water? Trends Biotechnol 2005; 23 (4): 163-7
19. Carlsen E, Giwercman A, Keiding N, et al. Evidence for decreasing quality of semen during past 50 years. BMJ 1992; 305: 609-13
20. Sherins RJ. Are semen quality and male fertility changing? N Engl J Med 1995; 332 (5): 327-8
21. Auger J, Kunstmann JM, Czyglik F, et al. Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med 1995; 332: 281-5
22. Knudsen FR, Schou AE, Wiborg ML, et al. Increase of plasma vitellogenin concentration in rainbow trout (Oncorhynchus mykiss) exposed to effluents from oil refinery treatment works and municipal sewage. Bull Environ Contam Toxicol 1997; 59: 802-6
23. Oaks JL, Gilbert M, Virani MZ, et al. Diclofenac residues as the cause of vulture population decline in Pakistan. Nature 2004; 427: 630-3
24. Liney KE, Jobling S, Shears JA, et al. Assessing the sensi-tivity of different life stages for sexual disruption in roach (Rutilus rutilus) exposed to effluents from wastewater treatment works. Environ Health Perspect 2005; 113 (10): 1299-307
25. Boxall ABA. The environmental side effects of medication: how are human and veterinary medicines in soils and water bodies affecting human and environmental health? EMBO Rep 2004; 5 (12): 1110-6
26. European Commission. Communication from the European Commission on the precautionary principle. Brussels; 2000 Feb 02 [online]. Available from URL: http://ec.europa.eu/environment/docum/20001-en.htm [Accessed 2010 Jun 16]
27. Stockholm County Council. Environmentally classified pharmaceuticals 2010 [online]. Available from URL: http://www.janusinfo.se/Global/ Miljo%20och%20lakeme del/miljo-broschyr-eng2010.pdf [Accessed 2010 Jun 16]
28. Directive 2004/28/EC of the European Parliament and of the Council of 31 March 2004 amending Directive 2001/82/EC on the community code relating to veterinary medicinal products [online]. Available from URL http://eur-lex. europa.eu/LexUriServ/LexUriServ.do-uri=CELEX:32004L 0028:EN:HTML [Accessed 2010 Jul 19].
29. Kummerer K, Velo G. Ecopharmacology: a new topic of importance in pharmacovigilance. Drug Saf 2006; 29 (5): 371-3
30. Liikanen E. Review of the pharmaceutical legislation. Speech/03/615 at the European Parliament Plenary Session, Strasbourg; 2003 Dec 16
31. European Commission. Safe, innovative and accessible medi-cines: a renewed vision for the pharmaceutical sector, 2008 Dec 10 [online]. Available from URL: http://ec.europa.eu/health/human-use/package-en.htm [Accessed 2010 Jun 16]
32. Carlsson C, Johansson AK, Alvan G, et al. Are pharmaceu-ticals potent environmental pollutants? Part I: environmental risk assessments of selected active pharmaceutical ingredients. Sci Total Environ 2006; 364: 67-87
33. Press Release of US Senator Kirsten E. Gillibrand, 2009 May 14 [online]. Available from URL: http://gillibrand.senate.gov/newsroom/press/release/-id= a19ef6cc-59e9-4ec1-994d-86ae56 f1628e [Accessed 2010 Jun 16]