Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism

Journal of Biological Chemistry

Volumn 285, Issue 42, 2010, Pages 32596-32605

  Fernandes, Margret S ^a,b   Reddy, Mamatha M ^a,b   Croteau, Nicole J ^a   Walz, Christoph ^c,d   Weisbach, Henry ^a   Podar, Klaus ^a,b,e   Band, Hamid ^f   Carroll, Martin ^g   Reiter, Andreas ^d   Larson, Richard A ^h   Salgia, Ravi ^h   Griffin, James D ^a,b   Sattler, Martin ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

^f UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE MYELOID LEUKEMIA; CANCER CELLS; CELLULAR BIOLOGY; CO-EXPRESSION; FUNCTIONAL EXPRESSION; GLUCOSE METABOLISM; GROWTH OF CELLS; GTPASES; HELICAL STRUCTURES; HEXOKINASES; KINASE ACTIVITY; LINKER SEQUENCE; MULTIPLE LEVELS; POINT MUTATIONS; REACTIVE OXYGEN SPECIES; RECEPTOR TYROSINE KINASE; SIGNALING EVENTS; SIGNALING MECHANISMS; SMALL-MOLECULE DRUGS; SPLICE SITE; TRANSFORMING ACTIVITY; TYROSINE KINASE; UBIQUITIN LIGASES;

AMINO ACIDS; CYTOLOGY; DISEASES; GLUCOSE; LIGANDS; OXYGEN; PHOSPHORYLATION; SIGNALING;

METABOLISM;

CBL PROTEIN; CD135 ANTIGEN; DEOXYGLUCOSE; FLT3 LIGAND; GLUCOSE; GUANOSINE TRIPHOSPHATASE; HEXOKINASE; MUTANT PROTEIN; PROTEIN CDC42; PROTEIN KINASE B; RAC PROTEIN; REACTIVE OXYGEN METABOLITE; RHO FACTOR; STAT5 PROTEIN; STEM CELL FACTOR RECEPTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; CANCER GROWTH; CELL CYCLE PROGRESSION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE IDENTIFICATION; GENE INSERTION; GENE MUTATION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; INTRACELLULAR SIGNALING; LEUKEMIA CELL; MALIGNANT TRANSFORMATION; METABOLIC REGULATION; MUTATION RATE; MUTATIONAL ANALYSIS; NONHUMAN; ONCOGENE; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RING FINGER MOTIF;

ANIMALS; BASE SEQUENCE; CELL CYCLE; CELL LINE; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DNA MUTATIONAL ANALYSIS; FMS-LIKE TYROSINE KINASE 3; GLUCOSE; GTP-BINDING PROTEINS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE; MOLECULAR SEQUENCE DATA; MUTATION; ONCOGENES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-CBL; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR;

EID: 77957780591     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.106161     Document Type: Article

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