메뉴 건너뛰기




Volumn 173, Issue 3-4, 2010, Pages 219-227

Changes of cytokines and IgG antibody in chickens vaccinated with DNA vaccines encoding Eimeria acervulina lactate dehydrogenase

Author keywords

Cytokine; DNA vaccine; E. acervulina; IgG; LDH

Indexed keywords

DNA VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 27; INTERLEUKIN 4; LACTATE DEHYDROGENASE; MESSENGER RNA; PLASMID VECTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA 4; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL GROWTH INHIBITOR; WATER;

EID: 77957780551     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2010.06.030     Document Type: Article
Times cited : (32)

References (55)
  • 1
    • 4944226419 scopus 로고    scopus 로고
    • Characterisation of the antigenic and immunogenic properties of bacterially expressed, sexual stage antigens of the coccidian parasite, Eimeria maxima
    • Belli S.I., Mai K., Skene C.D., Gleeson M.T., Witcombe D.M., Katrib M., Finger A., Wallach M.G., Smith N.C. Characterisation of the antigenic and immunogenic properties of bacterially expressed, sexual stage antigens of the coccidian parasite, Eimeria maxima. Vaccine 2004, 22:4316-4325.
    • (2004) Vaccine , vol.22 , pp. 4316-4325
    • Belli, S.I.1    Mai, K.2    Skene, C.D.3    Gleeson, M.T.4    Witcombe, D.M.5    Katrib, M.6    Finger, A.7    Wallach, M.G.8    Smith, N.C.9
  • 2
    • 0024494425 scopus 로고
    • Sensitivity of field isolates of Eimeria species to monensin and lasalocid in the chicken
    • Chapman H.D., Shirly M.W. Sensitivity of field isolates of Eimeria species to monensin and lasalocid in the chicken. Res. Vet. Sci. 1989, 46:114-117.
    • (1989) Res. Vet. Sci. , vol.46 , pp. 114-117
    • Chapman, H.D.1    Shirly, M.W.2
  • 3
    • 0032722009 scopus 로고    scopus 로고
    • Changes in local IFN-γ and TGF-β4 mRNA expression and intraepithelial lymphocytes following Eimeria acervulina infection
    • Choi K.D., Lillehoj H.S., Zalenga D.S. Changes in local IFN-γ and TGF-β4 mRNA expression and intraepithelial lymphocytes following Eimeria acervulina infection. Vet. Immunol. Immunopathol. 1999, 71:263-275.
    • (1999) Vet. Immunol. Immunopathol. , vol.71 , pp. 263-275
    • Choi, K.D.1    Lillehoj, H.S.2    Zalenga, D.S.3
  • 4
    • 44349182510 scopus 로고    scopus 로고
    • Antibody response against endogenous stages of an attenuated strain of Eimeria tenella
    • Constantinoiu C.C., Molloy J.B., Jorgensen W.K., Coleman G.T. Antibody response against endogenous stages of an attenuated strain of Eimeria tenella. Vet. Parasitol. 2008, 154:193-204.
    • (2008) Vet. Parasitol. , vol.154 , pp. 193-204
    • Constantinoiu, C.C.1    Molloy, J.B.2    Jorgensen, W.K.3    Coleman, G.T.4
  • 5
    • 67349214988 scopus 로고    scopus 로고
    • Host response to simultaneous infections with Eimeria acervulina, maxima and tenella: a cumulation of single responses
    • Cornelissen J.B.W.J., Swinkels W.J.C., Boersma W.A., Rebel J.M.J. Host response to simultaneous infections with Eimeria acervulina, maxima and tenella: a cumulation of single responses. Vet. Parasitol. 2009, 162:58-66.
    • (2009) Vet. Parasitol. , vol.162 , pp. 58-66
    • Cornelissen, J.B.W.J.1    Swinkels, W.J.C.2    Boersma, W.A.3    Rebel, J.M.J.4
  • 6
    • 15244363529 scopus 로고    scopus 로고
    • Recent advances in immunomodulation and vaccination strategies against coccidiosis
    • Dalloul R.A., Lillehoj H.S. Recent advances in immunomodulation and vaccination strategies against coccidiosis. Avian Dis. 2005, 49:1-8.
    • (2005) Avian Dis. , vol.49 , pp. 1-8
    • Dalloul, R.A.1    Lillehoj, H.S.2
  • 8
    • 18844384922 scopus 로고    scopus 로고
    • In ovo vaccination with the Eimeria tenella EtMIC2 gene induces protective immunity against coccidiosis
    • Ding X., Lillehoj H.S., Dalloul R.A., Min W., Sato T., Yasuda A., Lillehoj E.P. In ovo vaccination with the Eimeria tenella EtMIC2 gene induces protective immunity against coccidiosis. Vaccine 2005, 23:3733-3740.
    • (2005) Vaccine , vol.23 , pp. 3733-3740
    • Ding, X.1    Lillehoj, H.S.2    Dalloul, R.A.3    Min, W.4    Sato, T.5    Yasuda, A.6    Lillehoj, E.P.7
  • 9
    • 9244225664 scopus 로고    scopus 로고
    • Protective immunity against Eimeria acervulina following in ovo immunization with a recombinant subunit vaccine and cytokine genes
    • Ding X., Lillehoj H.S., Quiroz M.A., Bevensee E., Lillehoj E.P. Protective immunity against Eimeria acervulina following in ovo immunization with a recombinant subunit vaccine and cytokine genes. Infect. Immun. 2004, 72:6939-6944.
    • (2004) Infect. Immun. , vol.72 , pp. 6939-6944
    • Ding, X.1    Lillehoj, H.S.2    Quiroz, M.A.3    Bevensee, E.4    Lillehoj, E.P.5
  • 10
    • 19544383983 scopus 로고    scopus 로고
    • Efficacy of a DNA vaccine delivered in attenuated Salmonella typhimurium against Eimeria tenella infection in chickens
    • Du A., Wang S. Efficacy of a DNA vaccine delivered in attenuated Salmonella typhimurium against Eimeria tenella infection in chickens. Int. J. Parasitol. 2005, 35:777-785.
    • (2005) Int. J. Parasitol. , vol.35 , pp. 777-785
    • Du, A.1    Wang, S.2
  • 11
    • 0036663448 scopus 로고    scopus 로고
    • The use of cytokines and chemokines as genetic adjuvants for plasmid DNA vaccines
    • Egan M.A., Israel Z.R. The use of cytokines and chemokines as genetic adjuvants for plasmid DNA vaccines. Clin. Appl. Immunol. Rev. 2002, 2:255-287.
    • (2002) Clin. Appl. Immunol. Rev. , vol.2 , pp. 255-287
    • Egan, M.A.1    Israel, Z.R.2
  • 14
    • 0141818921 scopus 로고    scopus 로고
    • Abrus pulchellus type-2 RIP, pulchellin: heterologous expression and refolding of the sugar-binding B chain
    • Goto L.S., Beltramini L.M., Moraes D.I., Moreira R.A., Araújo A.P.U. Abrus pulchellus type-2 RIP, pulchellin: heterologous expression and refolding of the sugar-binding B chain. Protein Exp. Purif. 2003, 31:12-18.
    • (2003) Protein Exp. Purif. , vol.31 , pp. 12-18
    • Goto, L.S.1    Beltramini, L.M.2    Moraes, D.I.3    Moreira, R.A.4    Araújo, A.P.U.5
  • 16
    • 33750349817 scopus 로고    scopus 로고
    • Analysis of chicken cytokine and chemokine gene expression following Eimeria acervulina and Eimeria tenella infections
    • Hong Y.H., Lillehoj H.S., Lee S.H., Dalloul R.A., Lillehoj E.P. Analysis of chicken cytokine and chemokine gene expression following Eimeria acervulina and Eimeria tenella infections. Vet. Immunol. Immunopathol. 2006, 114:209-223.
    • (2006) Vet. Immunol. Immunopathol. , vol.114 , pp. 209-223
    • Hong, Y.H.1    Lillehoj, H.S.2    Lee, S.H.3    Dalloul, R.A.4    Lillehoj, E.P.5
  • 17
    • 33750290277 scopus 로고    scopus 로고
    • Changes in immune-related gene expression and intestinal lymphocyte subpopulations following Eimeria maxima infection of chickens
    • Hong Y.H., Lillehoj H.S., Lillehoj E.P., Lee S.H. Changes in immune-related gene expression and intestinal lymphocyte subpopulations following Eimeria maxima infection of chickens. Vet. Immunol. Immunopathol. 2006, 114:259-272.
    • (2006) Vet. Immunol. Immunopathol. , vol.114 , pp. 259-272
    • Hong, Y.H.1    Lillehoj, H.S.2    Lillehoj, E.P.3    Lee, S.H.4
  • 21
    • 0035925613 scopus 로고    scopus 로고
    • Modulation of antigen-specific cellular immune responses to DNA vaccination in rhesus macaques through the use of IL-2 IFN-γ, or IL-4 gene adjuvants
    • Kim J.J., Yang J., Manson K.H., Weiner D.B. Modulation of antigen-specific cellular immune responses to DNA vaccination in rhesus macaques through the use of IL-2 IFN-γ, or IL-4 gene adjuvants. Vaccine 2001, 19:2496-2505.
    • (2001) Vaccine , vol.19 , pp. 2496-2505
    • Kim, J.J.1    Yang, J.2    Manson, K.H.3    Weiner, D.B.4
  • 22
    • 34249705896 scopus 로고    scopus 로고
    • Effects of Pediococcus-and Saccharomyces-based probiotic (MitoMax) on coccidiosis in broiler chickens
    • Lee S., Lillehoj H.S., Park D.W., Hong Y.H., Lin J.J. Effects of Pediococcus-and Saccharomyces-based probiotic (MitoMax) on coccidiosis in broiler chickens. Comp. Immunol. Microbiol. Infect. Dis. 2007, 30:261-268.
    • (2007) Comp. Immunol. Microbiol. Infect. Dis. , vol.30 , pp. 261-268
    • Lee, S.1    Lillehoj, H.S.2    Park, D.W.3    Hong, Y.H.4    Lin, J.J.5
  • 23
    • 0345643410 scopus 로고    scopus 로고
    • Production of recombinant subunit vaccines: protein immunogens, live delivery systems and nucleic acid vaccines
    • Liljeqvist S., Ståhl S. Production of recombinant subunit vaccines: protein immunogens, live delivery systems and nucleic acid vaccines. J. Biotechnol. 1999, 73:1-33.
    • (1999) J. Biotechnol. , vol.73 , pp. 1-33
    • Liljeqvist, S.1    Ståhl, S.2
  • 24
    • 0032128399 scopus 로고    scopus 로고
    • Role of T lymphocytes and cytokines in coccidiosis
    • Lillehoj H.S. Role of T lymphocytes and cytokines in coccidiosis. Int. J. Parasitol. 1998, 28:1071-1081.
    • (1998) Int. J. Parasitol. , vol.28 , pp. 1071-1081
    • Lillehoj, H.S.1
  • 25
    • 0034088252 scopus 로고    scopus 로고
    • A recombinant Eimeria protein inducing interferon-gamma production: comparison of different gene expression systems and immunization strategies for vaccination against coccidiosis
    • Lillehoj H.S., Choi K.D., Jenkins M.C., Vakharia V.N., Song K.D., Han J.Y., Lillehoj E.P. A recombinant Eimeria protein inducing interferon-gamma production: comparison of different gene expression systems and immunization strategies for vaccination against coccidiosis. Avian Dis. 2000, 44:379-389.
    • (2000) Avian Dis. , vol.44 , pp. 379-389
    • Lillehoj, H.S.1    Choi, K.D.2    Jenkins, M.C.3    Vakharia, V.N.4    Song, K.D.5    Han, J.Y.6    Lillehoj, E.P.7
  • 26
    • 15244359261 scopus 로고    scopus 로고
    • Resistance to intestinal coccidiosis following DNA immunization with the cloned 3-1E Eimeria gene plus IL-2 IL-15, and IFN-γ
    • Lillehoj H.S., Ding X., Quiroz M.A., Bevensee E., Lillehoj E.P. Resistance to intestinal coccidiosis following DNA immunization with the cloned 3-1E Eimeria gene plus IL-2 IL-15, and IFN-γ. Avian Dis. 2005, 49:112-117.
    • (2005) Avian Dis. , vol.49 , pp. 112-117
    • Lillehoj, H.S.1    Ding, X.2    Quiroz, M.A.3    Bevensee, E.4    Lillehoj, E.P.5
  • 27
    • 0025179215 scopus 로고
    • Effects of major histocompatibility genes and antigen delivery on induction of protective mucosal immunity to E. acervulina following immunization with a recombinant merozoite antigen
    • Lillehoj H.S., Jenkins M.C., Bacon L.D. Effects of major histocompatibility genes and antigen delivery on induction of protective mucosal immunity to E. acervulina following immunization with a recombinant merozoite antigen. Immunology 1990, 71:127-132.
    • (1990) Immunology , vol.71 , pp. 127-132
    • Lillehoj, H.S.1    Jenkins, M.C.2    Bacon, L.D.3
  • 28
    • 0030035870 scopus 로고    scopus 로고
    • Avian gut-associated lymphoid tissues and intestinal immune responses to Eimeria parasites
    • Lillehoj H.S., Trout J.M. Avian gut-associated lymphoid tissues and intestinal immune responses to Eimeria parasites. Clin. Microbiol. Rev. 1996, 9:349-360.
    • (1996) Clin. Microbiol. Rev. , vol.9 , pp. 349-360
    • Lillehoj, H.S.1    Trout, J.M.2
  • 29
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Mothods 2001, 25:402-408.
    • (2001) Mothods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 31
    • 0028407357 scopus 로고
    • Mitogen-induced lymphocyte proliferation and interferon production following coccidia infection
    • Martin A., Lillehoj H.S., Kaspers B., Bacon L.D. Mitogen-induced lymphocyte proliferation and interferon production following coccidia infection. Avian Dis. 1994, 38:262-268.
    • (1994) Avian Dis. , vol.38 , pp. 262-268
    • Martin, A.1    Lillehoj, H.S.2    Kaspers, B.3    Bacon, L.D.4
  • 33
    • 0035850966 scopus 로고    scopus 로고
    • Adjuvant effects of IL-1β, IL-2, IL-8, IL-15, IFN-α IFN-γ TGF-β4 and lymphotactin on DNA vaccination against Eimeria acervulina
    • Min W., Lillehoj H.S., Burnside J., Weining K.C., Staeheli P., Zhu J.J. Adjuvant effects of IL-1β, IL-2, IL-8, IL-15, IFN-α IFN-γ TGF-β4 and lymphotactin on DNA vaccination against Eimeria acervulina. Vaccine 2002, 20:267-274.
    • (2002) Vaccine , vol.20 , pp. 267-274
    • Min, W.1    Lillehoj, H.S.2    Burnside, J.3    Weining, K.C.4    Staeheli, P.5    Zhu, J.J.6
  • 36
    • 34147105646 scopus 로고    scopus 로고
    • Functional characterization of tumor necrosis factor superfamily 15 (TNFSF 15) induced by lipopolysacchariges and Eimeria infection
    • Park S.S., Lillehoj H.S., Hong Y.H., Lee S.H. Functional characterization of tumor necrosis factor superfamily 15 (TNFSF 15) induced by lipopolysacchariges and Eimeria infection. Dev. Comp. Immunol. 2007, 31:934-944.
    • (2007) Dev. Comp. Immunol. , vol.31 , pp. 934-944
    • Park, S.S.1    Lillehoj, H.S.2    Hong, Y.H.3    Lee, S.H.4
  • 37
    • 0037248457 scopus 로고    scopus 로고
    • A single dose of recombinant Salmonella typhimurium induces specific humoral immune responses against heterologous Eimeria tenella antigens in chicken
    • Pogonka T., Klotz C., Kovács F., Lucius R. A single dose of recombinant Salmonella typhimurium induces specific humoral immune responses against heterologous Eimeria tenella antigens in chicken. Int. J. Parasitol. 2003, 33:81-88.
    • (2003) Int. J. Parasitol. , vol.33 , pp. 81-88
    • Pogonka, T.1    Klotz, C.2    Kovács, F.3    Lucius, R.4
  • 38
    • 70449529510 scopus 로고    scopus 로고
    • Induction of protective immunity by multiantigenic DNA vaccine delivered in attenuated Salmonella typhimurium against Toxoplasma gondii infection in mice
    • Qu D., Yu H., Wang S., Cai W., Du A. Induction of protective immunity by multiantigenic DNA vaccine delivered in attenuated Salmonella typhimurium against Toxoplasma gondii infection in mice. Vet. Parasitol. 2009, 166:220-227.
    • (2009) Vet. Parasitol. , vol.166 , pp. 220-227
    • Qu, D.1    Yu, H.2    Wang, S.3    Cai, W.4    Du, A.5
  • 40
    • 0034641034 scopus 로고    scopus 로고
    • Dynamics of lymphocyte subpopulation changes in the cecal tonsils of chickens infected with Salmonella enteritidis
    • Sasai K., Aita M., Lillehoj H.S., Miyamoto T., Fukata T., Baba E. Dynamics of lymphocyte subpopulation changes in the cecal tonsils of chickens infected with Salmonella enteritidis. Vet. Microbiol. 2000, 74:345-351.
    • (2000) Vet. Microbiol. , vol.74 , pp. 345-351
    • Sasai, K.1    Aita, M.2    Lillehoj, H.S.3    Miyamoto, T.4    Fukata, T.5    Baba, E.6
  • 42
    • 76049109681 scopus 로고    scopus 로고
    • Cross immunity of DNA vaccine pVAX1-cSZ2-IL-2 to Eimeria tenella, E. necatrix and E. maxima
    • Shah M.A.A., Xu L., Yan R., Song X., Li X. Cross immunity of DNA vaccine pVAX1-cSZ2-IL-2 to Eimeria tenella, E. necatrix and E. maxima. Exp. Parasitol. 2010, 124:330-333.
    • (2010) Exp. Parasitol. , vol.124 , pp. 330-333
    • Shah, M.A.A.1    Xu, L.2    Yan, R.3    Song, X.4    Li, X.5
  • 43
    • 77951091761 scopus 로고    scopus 로고
    • A recombinant DNA vaccine encoding Eimeria acervulina cSZ-2 induces immunity against experimental E. tenella infection
    • Shah M.A.A., Yan R., Song X., Xu L., Li X. A recombinant DNA vaccine encoding Eimeria acervulina cSZ-2 induces immunity against experimental E. tenella infection. Vet. Parasitol. 2009, 10.1016/j.vetpar.2009.12.035.
    • (2009) Vet. Parasitol.
    • Shah, M.A.A.1    Yan, R.2    Song, X.3    Xu, L.4    Li, X.5
  • 44
    • 0034666725 scopus 로고    scopus 로고
    • A DNA vaccine encoding a conserved Eimeria protein induces protective immunity against live Eimeria acervulina challenge
    • Song K.D., Lillehoj H.S., Choi K.D., Yun C.H., Parcells M.S., Huynh J.T., Han J.Y. A DNA vaccine encoding a conserved Eimeria protein induces protective immunity against live Eimeria acervulina challenge. Vaccine 2001, 19:243-252.
    • (2001) Vaccine , vol.19 , pp. 243-252
    • Song, K.D.1    Lillehoj, H.S.2    Choi, K.D.3    Yun, C.H.4    Parcells, M.S.5    Huynh, J.T.6    Han, J.Y.7
  • 45
    • 77955280279 scopus 로고    scopus 로고
    • Efficacy of DNA vaccines carrying Eimeria acervulina lactate dehydrogenase antigen gene against coccidiosis
    • Song H., Yan R., Xu L., Song X., Shah M.A.A., Zhu H., Li X. Efficacy of DNA vaccines carrying Eimeria acervulina lactate dehydrogenase antigen gene against coccidiosis. Exp. Parasitol. 2010, 10.1016/j.exppara.2010.05.015.
    • (2010) Exp. Parasitol.
    • Song, H.1    Yan, R.2    Xu, L.3    Song, X.4    Shah, M.A.A.5    Zhu, H.6    Li, X.7
  • 46
    • 57649219769 scopus 로고    scopus 로고
    • The optimal immunization procedure of DNA vaccine pcDNA-TA4-IL-2 of Eimeria tenella and its cross immunity to Eimeria necatrix and Eimeria acervulina
    • Song X., Xu L., Yan R., Huang X., Shah M.A.A., Li X. The optimal immunization procedure of DNA vaccine pcDNA-TA4-IL-2 of Eimeria tenella and its cross immunity to Eimeria necatrix and Eimeria acervulina. Vet. Parasitol. 2009, 159:30-36.
    • (2009) Vet. Parasitol. , vol.159 , pp. 30-36
    • Song, X.1    Xu, L.2    Yan, R.3    Huang, X.4    Shah, M.A.A.5    Li, X.6
  • 47
    • 0031570826 scopus 로고    scopus 로고
    • A cloned chicken lymphokine homologous to both mammalian IL-2 and IL-15
    • Sundick R.S., Gill-Dixon C. A cloned chicken lymphokine homologous to both mammalian IL-2 and IL-15. J. Immunol. 1997, 159:720-725.
    • (1997) J. Immunol. , vol.159 , pp. 720-725
    • Sundick, R.S.1    Gill-Dixon, C.2
  • 48
    • 33646410713 scopus 로고    scopus 로고
    • Immune responses in Eimeria acervulina infected one-day-old broilers compared to amount of Eimeria in the duodenum, measured by real-time PCR
    • Swinkels W.J.C., Post J., Cornelissen J.B., Engel B., Boersma W.J.A., Rebel J.M.J. Immune responses in Eimeria acervulina infected one-day-old broilers compared to amount of Eimeria in the duodenum, measured by real-time PCR. Vet. Parasitol. 2006, 138:223-233.
    • (2006) Vet. Parasitol. , vol.138 , pp. 223-233
    • Swinkels, W.J.C.1    Post, J.2    Cornelissen, J.B.3    Engel, B.4    Boersma, W.J.A.5    Rebel, J.M.J.6
  • 49
    • 20644463197 scopus 로고    scopus 로고
    • Molecular cloning and functional characterizations of chicken TL1A
    • Takimoto T., Takahashi K., Sato K., Akiba Y. Molecular cloning and functional characterizations of chicken TL1A. Dev. Comp. Immunol. 2005, 29:895-905.
    • (2005) Dev. Comp. Immunol. , vol.29 , pp. 895-905
    • Takimoto, T.1    Takahashi, K.2    Sato, K.3    Akiba, Y.4
  • 51
    • 0032128060 scopus 로고    scopus 로고
    • Progress in recombinant vaccine development against coccidiosis: a review and prospects into the next millennium
    • Vermeulen A.N. Progress in recombinant vaccine development against coccidiosis: a review and prospects into the next millennium. Int. J. Parasitol. 1998, 28:1121-1130.
    • (1998) Int. J. Parasitol. , vol.28 , pp. 1121-1130
    • Vermeulen, A.N.1
  • 53
    • 0028966752 scopus 로고
    • DNA-mediated immunization and the energetic immune response to hepatitis B surface antigen
    • Whalen R.G., Davis H.L. DNA-mediated immunization and the energetic immune response to hepatitis B surface antigen. Clin. Immunol. Immunopathol. 1995, 75:1-12.
    • (1995) Clin. Immunol. Immunopathol. , vol.75 , pp. 1-12
    • Whalen, R.G.1    Davis, H.L.2
  • 54
    • 50249159077 scopus 로고    scopus 로고
    • Vaccination of chickens with a chimeric DNA vaccine encoding Eimeria tenella TA4 and chicken IL-2 induces protective immunity against coccidiosis
    • Xu Q., Song X., Xu L., Yan R., Shah M.A.A., Li X. Vaccination of chickens with a chimeric DNA vaccine encoding Eimeria tenella TA4 and chicken IL-2 induces protective immunity against coccidiosis. Vet. Parasitol. 2008, 156:319-323.
    • (2008) Vet. Parasitol. , vol.156 , pp. 319-323
    • Xu, Q.1    Song, X.2    Xu, L.3    Yan, R.4    Shah, M.A.A.5    Li, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.