Leishmania infantum proteophosphoglycans regurgitated by the bite of its natural sand fly vector, Lutzomyia longipalpis, promote parasite establishment in mouse skin and skin-distant tissues

Microbes and Infection

Volumn 12, Issue 11, 2010, Pages 875-879

  Rogers, Matthew Edward ^a,b   Corware, Karina ^a   Müller, Ingrid ^a   Bates, Paul Andrew ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

Leishmania infantum; Sand fly; Transmission; Visceral leishmaniasis

Indexed keywords

GLYCAN DERIVATIVE; PROTEOPHOSPHOGLYCAN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE CARRIER; EAR; FEMALE; INSECT BITE; LEISHMANIA INFANTUM; LEISHMANIASIS; MIDGUT; MIXED INFECTION; MOUSE; NONHUMAN; PARASITE TRANSMISSION; PRIORITY JOURNAL; PROMASTIGOTE; PSYCHODIDAE; PSYCHODIDAE LONGIPALPIS; SALIVA; SKIN; SPLEEN DISEASE;

ANIMALS; DISEASE VECTORS; FEMALE; INSECT BITES AND STINGS; LEISHMANIA INFANTUM; LEISHMANIASIS, CUTANEOUS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; PROTEOGLYCANS; PROTOZOAN PROTEINS; PSYCHODIDAE; REGURGITATION, GASTRIC; SKIN;

LEISHMANIA INFANTUM; LUTZOMYIA LONGIPALPIS; MUS; PHLEBOTOMINAE;

EID: 77957751969     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2010.05.014     Document Type: Article

References (14)

1. UNDP, World Bank, WHO Leishmaniasis http://www.who.int/tdr/diseases/leish/diseaseinfo.htm.
2. Peters N.C., Egen J.G., Secundino N., Debrabant A., Kimblin N., Kamhawi S., Lawyer P., Fay M.P., Germain R.N., Sacks D.L. In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies. Science 2008, 321:970-974.
3. Kimblin N., Peters N., Debrabant A., Secundino N., Egen J., Lawyer P., Fay M.P., Kamhawi S., Sacks D. Quantification of the infectious dose of Leishmania major transmitted to the skin by single sand flies. Proc. Natl. Acad. Sci. U S A 2008, 105:10125-10130.
4. Rogers M.E., Ilg T., Nikolaev A.V., Ferguson M.A., Bates P.A. Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG. Nature 2004, 430:463-467.
5. Rohousová I., Volf P. Sand fly saliva: effects on host immune response and Leishmania transmission. Folia Parasitol. 2006, 53:161-171.
6. Rogers M.E., Chance M.L., Bates P.A. The role of promastigote secretory gel in the origin and transmission of the infective stage of Leishmania mexicana by the sandfly Lutzomyia longipalpis. Parasitology 2002, 124:495-507.
7. Rogers M.E., Bates P.A. Leishmania manipulation of sand fly feeding behavior results in enhanced transmission. PLoS Pathog. 2007, 3:e91.
8. Stierhof Y.D., Bates P.A., Jacobson R.L., Rogers M.E., Schlein Y., Handman E., Ilg T. Filamentous proteophosphoglycan secreted by Leishmania promastigotes forms gel-like three-dimensional networks that obstruct the digestive tract of infected sand fly vectors. Eur. J. Cell Biol. 1999, 78:675-689.
9. Bates P.A. Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies. Int. J. Parasitol. 2007, 37:1097-1106.
10. Rogers M.E., Dillon R.D., Choi B., Kropf P., Bates P.A., Müller I. Proteophosphoglycans regurgitated by Leishmania-infected sand flies target the L-arginine metabolism of host macrophages to promote parasite survival. PLoS Pathog. 2009, 5:e1000555.
11. Gomes R., Teixeira C., Teixeira M.J., Oliveira F., Menezes M.J., Silva C., deOliveira C.I., Miranda J.C., Elnaiem D.E., Kamhawi S., Valenzuela J.G., Brodskyn C.I. Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model. Proc. Natl. Acad. Sci. U S A 2008, 105:7845-7850.
12. Ahmed S., Colmenares M., Soong L., Goldsmith-Pestana K., Munstermann L., Molina R., McMahon-Pratt D. Intradermal infection model for pathogenesis and vaccine studies of murine visceral leishmaniasis. Infect. Immun. 2003, 71:401-410.
13. Kropf P., Fuentes J.M., Fähnrich E., Arpa L., Herath S., Weber V., Soler G., Celada A., Modolell M., Müller I. Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo. FASEB J. 2005, 19:1000-1002.
14. Munder M., Choi B.-S., Rogers M., Kropf P. L-arginine deprivation impairs Leishmania major-specific T cell responses. Eur. J. Immunol. 2009, 14:2161-2172.