Genetic damage in cultured human keratinocytes stressed by long-term exposure to areca nut extracts

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 599, Issue 1-2, 2006, Pages 66-75

  Lai, Kuo Chu ^a   Lee, Te Chang ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

8 Hydroxyguanosine; Areca nut extract; Gene mutation; Keratinocytes; Micronuclei; Reactive oxygen species

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; 8 HYDROXYDEOXYGUANOSINE; ALCOHOL; ARECA NUT EXTRACT; ARECAIDINE; ARECOLINE; BENZO[A]PYRENE; GLUTATHIONE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MUTAGENIC AGENT; REACTIVE OXYGEN METABOLITE; SAFROLE; UNCLASSIFIED DRUG;

ARTICLE; BETEL NUT; CELL CULTURE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; CYTOPATHOLOGY; GENE LOCUS; GENE MUTATION; GENETIC DAMAGE; GENOTOXICITY; HUMAN; HUMAN CELL; KERATINOCYTE; LONG TERM EXPOSURE; MICRONUCLEUS; MUTAGENESIS; MUTATION RATE; OXIDATIVE STRESS; PRIORITY JOURNAL;

APOPTOSIS; ARECA; ARECOLINE; CELL LINE; CELL PROLIFERATION; DNA DAMAGE; GLUTATHIONE; GUANOSINE; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; KERATINOCYTES; MICRONUCLEUS TESTS; MUTATION; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES;

ARECA CATECHU; MAMMALIA; PIPER BETEL;

EID: 33745900527     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2006.01.005     Document Type: Article

References (64)

1. Sharan R.N. Association of betel nut with carcinogenesis. Cancer J. 9 (1996) 13-19
2. Ko Y.C., Huang Y.L., Lee C.H., Chen M.J., Lin L.M., and Tsai C.C. Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J. Oral Pathol. Med. 24 (1995) 450-453
3. Ko Y.C., Chiang T.A., Chang S.J., and Hsieh S.F. Prevalence of betel quid chewing habit in Taiwan and related sociodemographic factors. J. Oral Pathol. Med. 21 (1992) 261-264
4. Bhide S.V., Shivapurkar N.M., Gothoskar S.V., and Ranadive K.J. Carcinogenicity of betel quid ingredients: feeding mice with aqueous extract and the polyphenol fraction of betel nut. Br. J. Cancer 40 (1979) 922-926
5. Suri K., Goldman H.M., and Wells H. Carcinogenic effect of a dimethyl sulphoxide extract of betel nut on the mucosa of the hamster buccal pouch. Nature 230 (1971) 383-384
6. IARC. Betel-quid and areca nut chewing and some areca-nut related nitrosamines, IARC. Monogr. Eval. Carcinog. Risk. Chem. Hum. 85 (2003) 11-18
7. Hoffmann D., Brunnemann K.D., Prokopczyk B., and Djordjevic M.V. Tobacco-specific N-nitrosamines and areca-derived N-nitrosamines: chemistry, biochemistry, carcinogenicity, and relevance to humans. J. Toxicol. Environ. Health 41 (1994) 1-52
8. Chen C.L., Chi C.W., Chang K.W., and Liu T.Y. Safrole-like DNA adducts in oral tissue from oral cancer patients with a betel quid chewing history. Carcinogenesis 20 (1999) 2331-2334
9. Lee-Chen S.F., Chen C.L., Ho L.Y., Hsu P.C., Chang J.T., Sun C.M., Chi C.W., and Liu T.Y. Role of oxidative DNA damage in hydroxychavicol-induced genotoxicity. Mutagenesis 11 (1996) 519-523
10. Jeng J.H., Chang M.C., and Hahn L.J. Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives. Oral Oncol. 37 (2001) 477-492
11. IARC. Betel-quid and areca nut chewing, IARC. Monogr. Eval. Carcinog. Risk. Chem. Hum. 37 (1985) 137-202
12. Jeng J.H., Hahn L.J., Lin B.R., Hsieh C.C., Chan C.P., and Chang M.C. Effects of areca nut, inflorescence Piper betle extracts and arecoline on cytotoxicity, total and unscheduled DNA synthesis in cultured gingival keratinocytes. J. Oral Pathol. Med. 28 (1999) 64-71
13. Sundqvist K., and Grafstrom R.C. Effects of areca nut on growth, differentiation and formation of DNA damage in cultured human buccal epithelial cells. Int. J. Cancer 52 (1992) 305-310
14. Sundqvist K., Liu Y., Nair J., Bartsch H., Arvidson K., and Grafstrom R.C. Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. Cancer Res. 49 (1989) 5294-5298
15. Shirname L.P., Menon M.M., Nair J., and Bhide S.V. Correlation of mutagenicity and tumorigenicity of betel quid and its ingredients. Nutr. Cancer 5 (1983) 87-91
16. Shirname L.P., Menon M.M., and Bhide S.V. Mutagenicity of betel quid and its ingredients using mammalian test systems. Carcinogenesis 5 (1984) 501-503
17. Dave B.J., Trivedi A.H., and Adhvaryu S.G. In vitro genotoxic effects of areca nut extract and arecoline. J. Cancer Res. Clin. Oncol. 118 (1992) 283-288
18. Kumpawat K., Deb S., Ray S., and Chatterjee A. Genotoxic effect of raw betel-nut extract in relation to endogenous glutathione levels and its mechanism of action in mammalian cells. Mutat. Res. 538 (2003) 1-12
19. Kumpawat K., and Chatterjee A. The usefulness of cytogenetic parameters, level of p53 protein and endogenous glutathione as intermediate end-points in raw betel-nut genotoxicity. Hum. Exp. Toxicol. 22 (2003) 363-371
20. Ranadive K.J., Gothoskar S.V., Rao A.R., Tezabwalla B.U., and Ambaye R.Y. Experimental studies on betel nut and tobacco carcinogenicity. Int. J. Cancer 17 (1976) 469-476
21. Rao A.R., and Das P. Evaluation of the carcinogenicity of different preparations of areca nut in mice. Int. J. Cancer 43 (1989) 728-732
22. Rosin M.P. The influence of pH on the convertogenic activity of plant phenolics. Mutat. Res. 135 (1984) 109-113
23. Liu T.Y., Chen C.L., and Chi C.W. Oxidative damage to DNA induced by areca nut extract. Mutat. Res. 367 (1996) 25-31
24. Chen C.L., Chi C.W., and Liu T.Y. Hydroxyl radical formation and oxidative DNA damage induced by areca quid in vivo. J. Toxicol. Environ. Health A 65 (2002) 327-336
25. Nair U.J., Nair J., Friesen M.D., Bartsch H., and Ohshima H. Ortho- and meta-tyrosine formation from phenylalanine in human saliva as a marker of hydroxyl radical generation during betel quid chewing. Carcinogenesis 16 (1995) 1195-1198
26. Nair U.J., Obe G., Friesen M., Goldberg M.T., and Bartsch H. Role of lime in the generation of reactive oxygen species from betel-quid ingredients. Environ. Health Perspect. 98 (1992) 203-205
27. Wu L.L., Chiou C.C., Chang P.Y., and Wu. J.T. Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin. Chim. Acta 339 (2004) 1-9
28. Thomas S.J., and MacLennan R. Slaked lime and betel nut cancer in Papua New Guinea. Lancet 340 (1992) 577-578
29. Jeng J.H., Wang Y.J., Chiang B.L., Lee P.H., Chan C.P., Ho Y.S., Wang T.M., Lee J.J., Hahn L.J., and Chang M.C. Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline. Carcinogenesis 24 (2003) 1301-1315
30. Chang M.C., Wu H.L., Lee J.J., Lee P.H., Chang H.H., Hahn L.J., Lin B.R., Chen Y.J., and Jeng J.H. The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation. J. Biol. Chem. 279 (2004) 50676-50683
31. Scully C., Field J.K., and Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma 3: clinico-pathological applications. Oral Oncol. 36 (2000) 404-413
32. Scully C., Field J.K., and Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma 2: chromosomal aberrations. Oral Oncol. 36 (2000) 311-327
33. Scully C., Field J.K., and Tanzawa H. Genetic aberrations in oral or head and neck squamous cell carcinoma (SCCHN). 1. Carcinogen metabolism, DNA repair and cell cycle control. Oral Oncol. 36 (2000) 256-263
34. Hofseth L.J. The adaptive imbalance to genotoxic stress: genome guardians rear their ugly heads. Carcinogenesis 25 (2004) 1787-1793
35. Karpinets T.V., and Foy B.D. Tumorigenesis: the adaptation of mammalian cells to sustained stress environment by epigenetic alterations and succeeding matched mutations. Carcinogenesis 26 (2005) 1323-1334
36. Stoler D.L., Chen N., Basik M., Kahlenberg M.S., Rodriguez-Bigas M.A., Petrelli N.J., and Anderson G.R. The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 15121-15126
37. Sieber O., Heinimann K., and Tomlinson I. Genomic stability and tumorigenesis. Semin. Cancer Biol. 15 (2005) 61-66
38. Chang M.C., Chiang C.P., Lin C.L., Lee J.J., Hahn L.J., and Jeng J.H. Cell-mediated immunity and head and neck cancer: with special emphasis on betel quid chewing habit. Oral Oncol. 41 (2005) 757-775
39. Boukamp P., Petrussevska R.T., Breitkreutz D., Hornung J., Markham A., and Fusenig N.E. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106 (1988) 761-771
40. Ho I.C., and Lee T.C. Sodium arsenite enhances copper accumulation in human lung adenocarcinoma cells. Toxicol. Sci. 47 (1999) 176-180
41. Skehan P., Storeng R., Scudiero D., Monks A., McMahon J., Vistica D., Warren J.T., Bokesch H., Kenney S., and Boyd M.R. New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst. 82 (1990) 1107-1112
42. Darzynkiewicz Z., Bruno S., Del Bino G., Gorczyca W., Hotz M.A., Lassota P., and Traganos F. Features of apoptotic cells measured by flow cytometry. Cytometry 13 (1992) 795-808
43. Fenech M., and Morley A.A. Kinetochore detection in micronuclei: an alternative method for measuring chromosome loss. Mutagenesis 4 (1989) 98-104
44. Cohn V.H., and Lyle J. A fluorometric assay for glutathione. Anal. Biochem. 14 (1966) 434-440
45. Wang C.K., Su H.Y., and Lii C.K. Chemical composition and toxicity of Taiwanese betel quid extract. Food Chem. Toxicol. 37 (1999) 135-144
46. Albertini R.J. HPRT mutations in humans: biomarkers for mechanistic studies. Mutat. Res. 489 (2001) 1-16
47. Limoli C.L., Ponnaiya B., Corcoran J.J., Giedzinski E., Kaplan M.I., Hartmann A., and Morgan W.F. Genomic instability induced by high and low LET ionizing radiation. Adv. Space Res. 25 (2000) 2107-2117
48. Chang M.C., Kuo M.Y., Hahn L.J., Hsieh C.C., Lin S.K., and Jeng J.H. Areca nut extract inhibits the growth, attachment, and matrix protein synthesis of cultured human gingival fibroblasts. J. Periodontol. 69 (1998) 1092-1097
49. Chang M.C., Ho Y.S., Lee P.H., Chan C.P., Lee J.J., Hahn L.J., Wang Y.J., and Jeng J.H. Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential. Carcinogenesis 22 (2001) 1527-1535
50. Hahn W.C., and Weinberg R.A. Rules for making human tumor cells. N. Engl. J. Med. 347 (2002) 1593-1603
51. Loeb L.A. A mutator phenotype in cancer. Cancer Res. 61 (2001) 3230-3239
52. Panigrahi G.B., and Rao A.R. Study of the genotoxicity of the total aqueous extract of betel nut and its tannin. Carcinogenesis 7 (1986) 37-39
53. Harvey M., Vogel H., Morris D., Bradley A., Bernstein A., and Donehower L.A. A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice. Nat. Genet. 9 (1995) 305-311
54. Hofseth L.J., Khan M.A., Ambrose M., Nikolayeva O., Xu-Welliver M., Kartalou M., Hussain S.P., Roth R.B., Zhou X., Mechanic L.E., Zurer I., Rotter V., Samson L.D., and Harris C.C. The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. J. Clin. Invest. 112 (2003) 1887-1894
55. Yamada N.A., and Farber R.A. Induction of a low level of microsatellite instability by overexpression of DNA polymerase beta. Cancer Res. 62 (2002) 6061-6064
56. Nair U.J., Floyd R.A., Nair J., Bussachini V., Friesen M., and Bartsch H. Formation of reactive oxygen species and of 8-hydroxydeoxyguanosine in DNA in vitro with betel quid ingredients. Chem. Biol. Interact. 63 (1987) 157-169
57. Nair U.J., Friesen M., Richard I., MacLennan R., Thomas S., and Bartsch H. Effect of lime composition on the formation of reactive oxygen species from areca nut extract in vitro. Carcinogenesis 11 (1990) 2145-2148
58. Devasagayam T.P., Tilak J.C., Boloor K.K., Sane K.S., Ghaskadbi S.S., and Lele R.D. Free radicals and antioxidants in human health: current status and future prospects. J. Assoc. Phys. Ind. 52 (2004) 794-804
59. Shibutani S., Takeshita M., and Grollman A.P. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349 (1991) 431-434
60. CohenL S.M., and Ellwein B. Genetic errors, cell proliferation, and carcinogenesis. Cancer Res. 51 (1991) 6493-6505
61. Hursting S.D., Slaga T.J., Fischer S.M., DiGiovanni J., and Phang J.M. Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenic mice. J. Natl. Cancer Inst. 91 (1999) 215-225
62. Nery R. The metabolic interconversion of arecoline and arecoline 1-oxide in the rat. Biochem. J. 122 (1971) 503-508
63. Friesen C., Kiess Y., and Debatin K.M. A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells. Cell Death Differ. 11 Suppl. 1 (2004) S73-S85
64. Hedley D., and Chow S. Glutathione and cellular resistance to anti-cancer drugs. Meth. Cell Biol. 42 Pt. B (1994) 31-44