Hypoxia in abdominal aortic aneurysm supports a role for HIF-1α and Ets-1 as drivers of matrix metalloproteinase upregulation in human aortic smooth muscle cells

Journal of Vascular Research

Volumn 48, Issue 2, 2011, Pages 163-170

  Erdozain, Olivia J ^a   Pegrum, Susan ^a   Winrow, Vivienne R ^a   Horrocks, Michael ^a,b   Stevens, Cliff R ^a  

^a University of Bath   (United Kingdom)

^b ROYAL UNITED HOSPITAL   (United Kingdom)

Author keywords

Abdominal aortic aneurysm; Ets 1 transcription factor; Hypoxia; Hypoxia inducible factor 1 ; Matrix metalloproteinase

Indexed keywords

GELATIN; GELATINASE A; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERSTITIAL COLLAGENASE; MATRILYSIN; METALLOPROTEINASE; OXYGEN; STROMELYSIN;

ABDOMINAL AORTA ANEURYSM; ARTICLE; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; HYPOXIA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; MULTIPLEX POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SMOOTH MUSCLE FIBER; TUNICA MEDIA; UPREGULATION; ZYMOGRAPHY;

ANOXIA; AORTIC ANEURYSM, ABDOMINAL; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES, SECRETED; MYOCYTES, SMOOTH MUSCLE; PROTO-ONCOGENE PROTEIN C-ETS-1; RNA, MESSENGER; UP-REGULATION;

EID: 77957748627     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000318806     Document Type: Article

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