Carbachol inhibits TNF-α-induced endothelial barrier dysfunction through alpha 7 nicotinic receptors

Acta Pharmacologica Sinica

Volumn 31, Issue 10, 2010, Pages 1389-1394

  Li, Yu Zhen ^a   Liu, Xiu Hua ^a   Rong, Fei ^a   Hu, Sen ^a   Sheng, Zhi Yong ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

alpha 7 nicotinic receptors; barrier function; carbachol; endothelium; ERK1 2; intercellular adhesion molecule 1; tumor necrosis factor

Indexed keywords

ALBUMIN; ALPHA BUNGAROTOXIN; CARBACHOL; F ACTIN; FLUORESCEIN ISOTHIOCYANATE; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINIC ALPHA 7 RECEPTOR; NICOTINIC RECEPTOR; PHALLOIDIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; IN VITRO STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

ACTINS; ANIMALS; ANTIGENS, CD; CADHERINS; CARBACHOL; CELLS, CULTURED; CHOLINERGIC AGONISTS; DOWN-REGULATION; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; INTERCELLULAR ADHESION MOLECULE-1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MICROVESSELS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 77957748513     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.165     Document Type: Article

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