Polymorphisms in catechol-O-methyltransferase and cytochrome p450 subfamily 19 genes predispose towards Madurella mycetomatis-induced mycetoma susceptibility

Medical Mycology

Volumn 48, Issue 7, 2010, Pages 959-968

  Van De Sande, Wendy W J ^a   Fahal, Ahmed ^b   Tavakol, Mehri ^a   Van Belkum, Alex ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF KHARTOUM   (Sudan)

Author keywords

DHEA; Estradiol; Ketoconazole; Mycetoma; Testosterone

Indexed keywords

AROMATASE; CATECHOL METHYLTRANSFERASE; CYTOCHROME P450 17; CYTOCHROME P450 1B1; ESTRADIOL; KETOCONAZOLE; PRASTERONE; PROGESTERONE; TESTOSTERONE;

ADOLESCENT; ADULT; AGED; ANDROGEN BLOOD LEVEL; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME POLYMORPHISM; ESTROGEN BLOOD LEVEL; FEMALE; GENE FREQUENCY; GENOTYPE; HORMONE DEFICIENCY; HORMONE DETERMINATION; HORMONE SYNTHESIS; HUMAN; IMMUNE STATUS; IN VITRO STUDY; MADURELLA MYCETOMATIS; MAJOR CLINICAL STUDY; MALE; MYCETOMA; SCHOOL CHILD; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALLELES; AROMATASE; CATECHOL O-METHYLTRANSFERASE; CHILD; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MADURELLA; MALE; MIDDLE AGED; MYCETOMA; POLYMORPHISM, SINGLE NUCLEOTIDE; SUDAN;

FUNGI; MADURELLA MYCETOMATIS;

EID: 77957747995     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.3109/13693781003636680     Document Type: Article

References (54)

1. Ahmed AO, van Leeuwen W, Fahal A, et al. Mycetoma caused by Madurella mycetomatis: a neglected infectious burden. Lancet Infect Dis 2004; 4: 566-574.
2. Ahmed A, Adelmann D, Fahal A, et al. Environmental occurrence of Madurella mycetomatis, the major agent of human eumycetoma in Sudan. J Clin Microbiol 2002; 40: 1031-1036.
3. Dieng MT, Sy MH, Diop BM, Niang SO, Ndiaye B. [Mycetoma: 130 cases]. Ann Dermatol Venereol 2003; 130: 16-19.
4. Denguezli M, Kourda M, Ghariani N, et al. [Mycetomas in central Tunisia]. Ann Dermatol Venereol 2003; 130: 515-518.
5. Maiti PK, Ray A, Bandyopadhyay S. Epidemiological aspects of myc-etoma from a retrospective study of 264 cases in West Bengal. Trop Med Int Health 2002; 7: 788-792.
6. Fahal AH. Mycetoma, Clinicopathological Monograph, 1st edn. Khartoum: Khartoum University Press; 2006.
7. Drutz DJ, Huppert M, Sun SH, McGuire WL. Human sex hormones stimulate the growth and maturation of Coccidioides immitis. Infect Immun 1981; 32: 897-907.
8. Restrepo A, Salazar ME, Cano LE, et al. Estrogens inhibit mycelium-to-yeast transformation in the fungus Paracoccidioides brasiliensis: implications for resistance of females to paracoccidioidomycosis. Infect Immun 1984; 46: 346-353.
9. Aristizabal BH, Clemons KV, Cock AM, Restrepo A, Stevens DA. Experimental Paracoccidioides brasiliensis infection in mice: infuence of the hormonal status of the host on tissue responses. Med Mycol 2002; 40: 169-178.
10. Aristizabal BH, Clemons KV, Stevens DA, Restrepo A. Morphologi-cal transition of Paracoccidioides brasiliensis conidia to yeast cells: in vivo inhibition in females. Infect Immun 1998; 66: 5587-5591.
11. Hernandez-Hernandez F, De Bievre C, Camacho-Arroyo I, et al. Sex hormone effects on Phialophora verrucosain vitro and characteriza-tion of progesterone receptors. J Med Vet Mycol 1995; 33: 235-239.
12. Butterworth M, McClellan B, Allansmith M. Inf uence of sex in im-munoglobulin levels. Nature 1967; 214: 1224-1225.
13. Klein SL. The effects of hormones on sex differences in infection: from genes to behavior. Neurosci Biobehav Rev 2000; 24: 627-638.
14. Azzi L, El-Alfy M, Labrie F. Gender differences and effects of sex steroids and dehydroepiandrosterone on androgen and oestrogen al-pha receptors in mouse sebaceous glands. Br J Dermatol 2006; 154: 21-27.
15. Punnonen R. Effect of castration and peroral estrogen therapy on the skin. Acta Obstet Gynecol Scand Suppl 1972; 21: 3-44.
16. Gilliver SC, Ashworth JJ, Ashcroft GS. The hormonal regulation of cutaneous wound healing. Clin Dermatol 2007; 25: 56-62.
17. Dunning AM, Dowsett M, Healey CS, et al. Polymorphisms associ-ated with circulating sex hormone levels in postmenopausal women. J Natl Cancer Inst 2004; 96: 936-945.
18. Rosmond R, Chagnon M, Bouchard C, Bjorntorp P. Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure. Biochem Biophys Res Commun 2002; 293:629-632.
19. Allen NE, Forrest MS, Key TJ. The association between polymor-phisms in the CYP17 and 5alpha-reductase (SRD5A2) genes and se-rum androgen concentrations in men. Cancer Epidemiol Biomarkers Prev 2001; 10: 185-189.
20. Ruiz-Sanz JI, Aurrekoetxea I, Ruiz del Agua A, Ruiz-Larrea MB. Detection of catechol-O-methyltransferase Val158Met polymorphism by a simple one-step tetra-primer amplif cation refractory mutation system-PCR. Mol Cell Probes 2007; 21: 202-207.
21. Peter I, Kelley-Hedgepeth A, Fox CS, et al. Variation in estrogen-re-lated genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels. J Clin Endocrinol Metab 2008; 93: 2779-2785.
22. Sasaki M, Tanaka Y, Kaneuchi M, Sakuragi N, Dahiya R. Alleles of polymorphic sites that correspond to hyperactive variants of CYP1B1 protein are signif cantly less frequent in Japanese as compared to American and German populations. Hum Mutat 2003; 21: 652.
23. Worda C, Sator MO, Schneeberger C, et al. Inf uence of the catechol-O-methyltransferase (COMT) codon 158 polymorphism on estrogen levels in women. Hum Reprod 2003; 18: 262-266.
24. Matheson MC, Ellis JA, Raven J, Walters EH, Abramson MJ. Asso-ciation of IL8, CXCR2 and TNF-alpha polymorphisms and airway disease. J Hum Genet 2006; 51: 196-203.
25. Ahmed AO, Mukhtar MM, Kools-Sijmons M, et al. Development of a species-specif c PCR-restriction fragment length polymorphism analysis procedure for identif cation of Madurella mycetomatis. J Clin Microbiol 1999; 37:3175-3178.
26. van de Sande WWJ, Gorkink R, Simons G, et al. Genotyping of Ma-durella mycetomatis by selective amplif cation of restriction fragments (Amplif ed Fragment Length Polymorphism) and subtype correlation with geographical origin and lesion size. J Clin Microbiol 2005; 43: 4349-4356.
27. van de Sande WWJ, Luijendijk A, Ahmed AO, Bakker-Woudenberg IA, van Belkum A. Testing of the in vitro susceptibilities of Madurella mycetomatis to six antifungal agents by using the Sensititre System in comparison with a viability-based 2, 3-Bis(2-Methoxy-4-Nitro-5-Sulfophenyl)-5-[(Phenylamino) Carbonyl]-2H-Tetrazolium Hydroxide (XTT) Assay and a Modif ed NCCLS Method. Antimicrob Agents Chemother 2005; 49: 1364-1368.
28. Ahmed AO, van de Sande WWJ, van Vianen W, et al. In vitro sus-ceptibilities of Madurella mycetomatis to itraconazole and ampho-tericin B assessed by a modif ed NCCLS method and a viability-based 2, 3-Bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino) carbonyl]-2H-tetrazolium hydroxide (XTT) assay. Antimicrob Agents Chemother 2004; 48: 2742-2746.
29. CLSI. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi; Approved Strandard. Wayne, Pennsylva-nia, USA: National Committee for Clinical Laboratory Standards; 2008.
30. Harrison PJ, Tunbridge EM. Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Neuropsy-chopharmacology 2008; 33: 3037-3045.
31. Cummings AM, Hedge JL, Laskey J. Ketoconazole impairs early pregnancy and the decidual cell response via alterations in ovarian function. Fundam Appl Toxicol 1997; 40: 238-246.
32. Harris AL, Cantwell BM, Dowsett M. High dose ketoconazole: en-docrine and therapeutic effects in postmenopausal breast cancer. Br J Cancer 1988; 58: 493-496.
33. Lionakis MS, Samonis G, Kontoyiannis DP. Endocrine and metabolic manifestations of invasive fungal infections and systemic antifungal treatment. Mayo Clin Proc 2008; 83: 1046-1060.
34. Sonino N. The use of ketoconazole as an inhibitor of steroid produc-tion. N Engl J Med 1987; 317: 812-818.
35. Effendy I, Krause W. In vivo effects of terbinaf ne and ketoconazole on testosterone plasma levels in healthy males. Dermatologica 1989; 178: 103-106.
36. De Coster R, Caers I, Haelterman C, Debroye M. Effect of a single ad-ministration of ketoconazole on total and physiologically free plasma testosterone and 17 beta-oestradiol levels in healthy male volunteers. Eur J Clin Pharmacol 1985; 29: 489-493.
37. Stover EP, Schar G, Clemons KV, Stevens DA, Feldman D. Estradiol-binding proteins from mycelial and yeast-form cultures of Paracoc-cidioides brasiliensis. Infect Immun 1986; 51: 199-203.
38. Loose DS, Stover EP, Restrepo A, Stevens DA, Feldman D. Estradiol binds to a receptor-like cytosol binding protein and initiates a biologi-cal response in Paracoccidioides brasiliensis. Proc Natl Acad Sci USA 1983; 80:7659-7663.
39. Mendez-Tovar LJ, de Bievre C, Lopez-Martinez R. Effects des hor-mones sexuelles humaines sur le development in vitro des agents d'eumycetomes. J Mycol Med 1991; 1: 141.
40. Hernandez-Hernandez F, Lopez-Martinez R, Mendez-Tovar LJ, Manzano-Gayosso P. Nocardia brasiliensis: in vitro and in vivo growth response to steroid sex hormones. Mycopathologia 1995; 132: 79-85.
41. Straub RH. The complex role of estrogens in inf ammation. Endocr Rev 2007; 28:521-574.
42. Ashcroft GS, Greenwell-Wild T, Horan MA, Wahl SM, Ferguson MW. Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inf ammatory response. Am J Pathol 1999; 155: 1137-1146.
43. Ashcroft GS, Mills SJ, Lei K, et al. Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J Clin Invest 2003; 111: 1309-1318.
44. Mathur S, Mathur RS, Dowda H, et al. Sex steroid hormones and anti-bodies to Candida albicans. Clin Exp Immunol 1978; 33: 79-87.
45. Osorio Y, Bonilla DL, Peniche AG, Melby PC, Travi BL. Pregnan-cy enhances the innate immune response in experimental cutaneous leishmaniasis through hormone-modulated nitric oxide production. J Leukoc Biol 2008; 83: 1413-1422.
46. van de Sande WWJ, Fahal A, Verbrugh H, van Belkum A. Polymor-phisms in genes involved in innate immunity predispose toward myc-etoma susceptibility. J Immunol 2007; 179: 3065-3074.
47. Shier WT, Shier AC, Xie W, Mirocha CJ. Structure-activity relation-ships for human estrogenic activity in zearalenone mycotoxins. Toxi-con 2001; 39: 1435-1438.
48. Minervini F, Giannoccaro A, Cavallini A, Visconti A. Investigations on cellular proliferation induced by zearalenone and its derivatives in relation to the estrogenic parameters. Toxicol Lett 2005; 159: 272-283.
49. Rey AD, Mahuad CV, Bozza VV, et al. Endocrine and cytokine re-sponses in humans with pulmonary tuberculosis. Brain Behav Immun 2007; 21: 171-179.
50. Leal AM, Magalhaes PK, Martinez R, Moreira AC Adrenocortical hormones and interleukin patterns in paracoccidioidomycosis. J Infect Dis 2003; 187: 124-127.
51. Tengstrand B, Carlstrom K, Fellander-Tsai L, Hafstrom I. Abnormal levels of serum dehydroepiandrosterone, estrone, and estradiol in men with rheumatoid arthritis: high correlation between serum es-tradiol and current degree of inf ammation. J Rheumatol 2003; 30: 2338-2343.
52. Auci D, Kaler L, Subramanian S, et al. A new orally bioavailable synthetic androstene inhibits collagen-induced arthritis in the mouse: androstene hormones as regulators of regulatory T cells. Ann N Y Acad Sci 2007; 1110: 630-640.
53. dos Santos CD, Toldo MP, do Prado Junior JC. Trypanosoma cruzi: the effects of dehydroepiandrosterone (DHEA) treatment during ex-perimental infection. Acta Trop 2005; 95: 109-115.
54. Hur SE, Lee S, Lee JY, et al. Polymorphisms and haplotypes of the gene encoding the estrogen-metabolizing CYP19 gene in Korean women: no association with advanced-stage endometriosis. J Hum Genet 2007; 52:703-711.