N-terminal and C-terminal heparin-binding domain polypeptides derived from fibronectin reduce adhesion and invasion of liver cancer cells

BMC Cancer

Volumn 10, Issue , 2010, Pages

  Tang, Nan Hong ^a   Chen, Yan Lin ^a   Wang, Xiao Qian ^a   Li, Xiu Jin ^a   Wu, Yong ^a   Zou, Qi Lian ^a   Chen, Yuan Zhong ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA1 INTEGRIN; BETA3 INTEGRIN; CD51 ANTIGEN; FIBRONECTIN; FOCAL ADHESION KINASE; GELATINASE B; HEPARIN BINDING PROTEIN; MATRIX METALLOPROTEINASE; POLYPEPTIDE; RECOMBINANT PROTEIN FNHC36; RECOMBINANT PROTEIN FNHN29; TRANSCRIPTION FACTOR AP 1; TYROSINE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; COLLAGEN; GLYCOPROTEIN; HEPARIN; LAMININ; MATRIGEL; PEPTIDE; PROTEOGLYCAN;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER INVASION; CARBOXY TERMINAL SEQUENCE; CARCINOMA CELL; CELL ADHESION; CELL STRAIN; CELL STRAIN MHCC97H; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LUNG METASTASIS; MALE; MOUSE; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION INITIATION; ANIMAL; CHEMISTRY; DRUG COMBINATION; LIVER TUMOR; METABOLISM; METASTASIS; NUDE MOUSE; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL LINE, TUMOR; COLLAGEN; DRUG COMBINATIONS; FIBRONECTINS; GLYCOPROTEINS; HEPARIN; HUMANS; LAMININ; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; PROTEOGLYCANS;

EID: 77957741276     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-552     Document Type: Article

References (42)

1. Niu JX, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN. The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion. Eur J Cancer Prev 2007, 16(6):517-527. 10.1097/CEJ.0b013e3280145c00, 18090124.
2. Riou P, Saffroy R, Chenailler C, Franc B, Gentile C, Rubinstein E, Resink T, Debuire B, Piatier-Tonneau D, Lemoine A. Expression of T-cadherin in tumor cells influences invasive potential of human hepatocellular carcinoma. FASEB J 2006, 20(13):2291-2301. 10.1096/fj.06-6085com, 17077306.
3. Song G, Ohashi T, Sakamoto N, Sato M. Adhesive force of human hepatoma HepG2 cells to endothelial cells and expression of E-selectin. Mol Cell Biomech 2006, 3(2):61-68.
4. Oosterling SJ, van der Bij GJ, Bögels M, ten Raa S, Post JA, Meijer GA, Beelen RH, van Egmond M. Anti-beta1 integrin antibody reduces surgery-induced adhesion of colon carcinoma cells to traumatized peritoneal surfaces. Ann Surg 2008, 247(1):85-94. 10.1097/SLA.0b013e3181588583, 18156927.
5. Nobumoto A, Nagahara K, Oomizu S, Katoh S, Nishi N, Takeshita K, Niki T, Tominaga A, Yamauchi A, Hirashima M. Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices. Glycobiology 2008, 18(9):735-744. 10.1093/glycob/cwn062, 18579572.
6. Gong W, Liu Y, Huang B, Lei Z, Wu FH, Li D, Feng ZH, Zhang GM. Recombinant CBD-HepII polypeptide of fibronectin inhibits alphavbeta3 signaling and hematogenous metastasis of tumor. Biochem Biophys Res Commun 2008, 367(1):144-149. 10.1016/j.bbrc.2007.12.110, 18162175.
7. Han S, Ritzenthaler JD, Sitaraman SV, Roman J. Fibronectin increases matrix metalloproteinase 9 expression through activation of c-Fos via extracellular-regulated kinase and phosphatidylinositol 3-kinase pathways in human lung carcinoma cells. J Biol Chem 2006, 281(40):29614-29624. 10.1074/jbc.M604013200, 16882662.
8. Liu W, Cheng S, Asa SL, Ezzat S. The melanoma-associated antigen A3 mediates fibronectin-controlled cancer progression and metastasis. Cancer Res 2008, 68(19):8104-8112. 10.1158/0008-5472.CAN-08-2132, 18829569.
9. Urtreger AJ, Werbajh SE, Verrecchia F, Mauviel A, Puricelli LI, Kornblihtt AR, Bal de Kier Joffé ED. Fibronectin is distinctly downregulated in murine mammary adenocarcinoma cells with high metastatic potential. Oncol Rep 2006, 16(6):1403-1410.
10. Gulubova M, Vlaykova T. Immunohistochemical assessment of fibronectin and tenascin and their integrin receptors alpha5beta1 and alpha9beta1 in gastric and colorectal cancers with lymph node and liver metastases. Acta Histochem 2006, 108(1):25-35. 10.1016/j.acthis.2005.12.001, 16430945.
11. Szaniawska B, Kleczkowska P, Trembacz H, Janik P, Lipkowski AW. A novel fibronectin-related structural motif that modulates cell migration. J Pept Res 2005, 66(Suppl 1):114-119.
12. Tsuchiya Y, Sawada S, Tsukada K, Saiki I. A new pseudo-peptide of Arg-Gly-Asp (RGD) inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma. Int J Oncol 2002, 20(2):319-324.
13. Liu Y, Huang B, Yuan Y, Gong W, Xiao H, Li D, Yu ZR, Wu FH, Zhang GM, Feng ZH. Inhibition of hepatocarcinoma and tumor metastasis to liver by gene therapy with recombinant CBD-HepII polypeptide of fibronectin. Int J Cancer 2007, 121(1):184-192. 10.1002/ijc.22644, 17330234.
14. Kato R, Ishikawa T, Kamiya S, Oguma F, Ueki M, Goto S, Nakamura H, Katayama T, Fukai F. A new type of antimetastatic peptide derived from fibronectin. Clin Cancer Res 2002, 8(7):2455-2462.
15. Kishore R, Samuel M, Khan MY, Hand J, Frenz DA, Newman SA. Interaction of the NH2-terminal domain of fibronectin with heparin. Role of the omega-loops of the type I modules. J Biol Chem 1997, 272(27):17078-17085. 10.1074/jbc.272.27.17078, 9202024.
16. Garcia-Pardo A, Rostagno A, Frangione B. Primary structure of human pkasma fibronectin. Characterization of a 38 kDa domain containing the C-terminal heparin-binding site (Hep III site) and a region of molecular heterogeneity. Biochem J 1987, 241(3):923-928. 1147649, 3593230.
17. Zou QL, Chen YZ, Chen XF, Wu Y, Chen P, Huang MJ. Expression of Recombinant Heparin-binding Fibronectin Polypeptide in Insect Cell/Baclovirus System and Its Bioactivities. China Biotechnology 2008, 28(6s):32-38. Chinese.
18. Tian J, Tang ZY, Ye SL, Liu YK, Lin ZY, Chen J, Xue Q. New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis. Br J Cancer 1999, 81(5):814-821. 10.1038/sj.bjc.6690769, 2374300, 10555751.
19. Fukai F, Mashimo M, Akiyama K, Goto T, Tanuma S, Katayama T. Modulation of apoptotic cell death by extracellular matrix proteins and a fibronectin-derived antiadhesive peptide. Exp Cell Res 1998, 242(1):92-99. 10.1006/excr.1998.4076, 9665806.
20. Li WC, Ye SL, Sun RX, Liu YK, Tang ZY, Kim Y, Karras JG, Zhang H. Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3. Clin Cancer Res 2006, 12(23):7140-7148. 10.1158/1078-0432.CCR-06-0484, 17145839.
21. Wang W, Wu F, Fang F, Tao Y, Yang L. Inhibition of invasion and metastasis of hepatocellular carcinoma cells via targeting RhoC in vitro and in vivo. Clin Cancer Res 2008, 14(21):6804-6812. 10.1158/1078-0432.CCR-07-4820, 18980974.
22. Iwai S, Nakanishi-Ueda T, Armstrong D, Oguchi K. Zymographical techniques for detection of matrix metalloproteinases. Methods Mol Biol 2008, 477:113-121. full_text, 19082943.
23. Sun YX, Fang M, Wang J, Cooper CR, Pienta KJ, Taichman RS. Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells. Prostate 2007, 67(1):61-73. 10.1002/pros.20500, 17034033.
24. Zheng H, Takahashi H, Murai Y, Cui Z, Nomoto K, Niwa H, Tsuneyama K, Takano Y. Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma. Anticancer Res 2006, 26(5A):3579-3583.
25. Garcia-Morales P, Minami Y, Luong E, Klausner RD, Samelson LE. Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide. Proc Natl Acad Sci USA 1990, 87(23):9255-9259. 10.1073/pnas.87.23.9255, 55143, 1701256.
26. Liu YK, Wu WZ, Wu X, Jiang Y, Zhou XD. Metastasis and recurrence of hepatocellular carcinoma--basic and clinical studies. Shanghai: Shanghai scientific and technological education public house 2003:93-104.
27. Heyder C, Gloria-Maercker E, Hatzmann W, Niggemann B, Zanker KS, Dittmar T. Role of the beta1-integrin subunit in the adhesion, extravasation and migration of T24 human bladder carcinoma cells. Clin Exp Metastasis 2005, 22(2):99-106. 10.1007/s10585-005-4335-z, 16086230.
28. Humphries MJ, Olden K, Yamada KM. A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells. Science 1986, 233(4762):467-470. 10.1126/science.3726541, 3726541.
29. Dechantsreiter MA, Planker E, Mathä B, Lohof E, Hölzemann G, Jonczyk A, Goodman SL, Kessler H. N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem 1999, 42(16):3033-3040. 10.1021/jm970832g, 10447947.
30. Peyman A, Wehner V, Knolle J, Stilz HU, Breipohl G, Scheunemann KH, Carniato D, Ruxer JM, Gourvest JF, Gadek TR, Bodary S. RGD mimetics containing a central hydantoin scaffold: alpkha(v)beta3 vs alpha(IIb)beta3 selectivity requirements. Bioorg Med Chem Lett 2000, 10(2):179-182. 10.1016/S0960-894X(99)00661-7, 10673106.
31. Wang SM, Zhu J, Pan LF, Liu YK. Inhibitory effect of dimeric beta peptide on the recurrence and metastasis of hepatocellular carcinoma in vitro and in mice. World J Gastroenterol 2008, 14(19):3054-3058. 10.3748/wjg.14.3054, 2712174, 18494058.
32. Lin KT, Yeh SH, Chen DS, Chen PJ, Jou YS. Epigenetic activation of alpha4, beta2 and beta6 integrins involved in cell migration in trichostatin A-treated Hep3B cells. J Biomed Sci 2005, 12(5):803-813. 10.1007/s11373-005-9005-2, 16132114.
33. Fu BH, Wu ZZ, Dong C. Integrin beta1 mediates hepatocellular carcinoma cells chemotaxis to laminin. Hepatobiliary Pancreat Dis Int 2004, 3(4):548-551.
34. Wu Y, Zuo J, Ji G, Saiyin H, Liu X, Yin F, Cao N, Wen Y, Li JJ, Yu L. Proapoptotic function of integrin beta(3) in human hepatocellular carcinoma cells. Clin Cancer Res 2009, 15(1):60-69. 10.1158/1078-0432.CCR-08-1028, 19118033.
35. Cowles EA, Brailey LL, Gronowicz GA. Integrin-mediated signaling regulates AP-1 transcription factors and proliferation in osteoblasts. J Biomed Mater Res 2000, 52(4):725-737. 10.1002/1097-4636(20001215)52:4<725::AID-JBM18>3.0.CO;2-O, 11033556.
36. Hamamura K, Tsuji M, Ohkawa Y, Nakashima H, Miyazaki S, Urano T, Yamamoto N, Ueda M, Furukawa K, Furukawa K. Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells. Biochim Biophys Acta 2008, 1780(3):513-519.
37. Van Slambrouck S, Grijelmo C, De Wever O, Bruyneel E, Emami S, Gespach C, Steelant WF. Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion. Int J Oncol 2007, 31(6):1501-1508.
38. Liang YL, Lei TW, Wu H, Su JM, Wang LY, Lei QY, Zha XL. S-phase delay in human hepatocellular carcinoma cells induced by overexpression of integrin beta1. World J Gastroenterol 2003, 9(8):1689-1696.
39. Corbi AL, Jensen UB, Watt FM. The alpha2 and alpha5 integrin genes:identification of transcription factors that regulate promoter activity in epidermal keratinocytes. FEBS Lett 2000, 474(2-3):201-207. 10.1016/S0014-5793(00)01591-X, 10838085.
40. Westermarck J, Kähäri VM. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 1999, 13(8):781-792.
41. Angel P, Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1991, 1072(2-3):129-157.
42. Stamenkovic I. Matrix metalloproteinases in tumor invasion and metastasis. Semin Cancer Biol 2000, 10(6):415-433. 10.1006/scbi.2000.0379, 11170864.