The role of adhesion molecules, αvβ3, αvβ5 and their ligands in the tumor cell and endothelial cell adhesion

European Journal of Cancer Prevention

Volumn 16, Issue 6, 2007, Pages 517-527

  Niu, Ji Xiao ^a   Zhang, Wen Jian ^b   Ye, Li Ya ^b   Wu, Lian Qiu ^b   Zhu, Guang Jin ^a   Yang, Zhi Hua ^c   Grau, Georges E ^d   Lou, Jin Ning ^b  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^c PEKING UNION MEDICAL COLLEGE   (China)

^d University of Sydney   (Australia)

Author keywords

v 3; v 5; Adhesion molecules; Endothelial cells; Tumor cells

Indexed keywords

ALPHAVBETA5 INTEGRIN; DEVELOPMENTAL ENDOTHELIAL LOCUS 1 PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; PROTEIN; PROTEIN ANTIBODY; PROTEIN L1; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL ADHESION; CONTROLLED STUDY; ENDOTHELIUM CELL; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIGAND BINDING; LIVER CANCER; LIVER SINUSOID; METASTASIS; PRIORITY JOURNAL; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; UPREGULATION;

CARRIER PROTEINS; CELL ADHESION; CELL ADHESION MOLECULES; CELL HYPOXIA; CELL LINE, TUMOR; CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIAL CELLS; HUMANS; INTEGRIN ALPHAVBETA3; INTEGRIN BETA CHAINS; LIGANDS; NEOPLASMS; NEURAL CELL ADHESION MOLECULE L1; RNA INTERFERENCE;

EID: 37349084516     PISSN: 09598278     EISSN: None     Source Type: Journal    
DOI: 10.1097/CEJ.0b013e3280145c00     Document Type: Article

References (37)

1. Albelda SM (2000). Role of integrins and other cell adhesion molecules in tumor progression and metastasis. Lab Invest 68:4-17.
2. Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R, et al. (2002). The embryonic angiogenic factor Del-1 accelerates tumor growth by enhancing vascular formation. Microvasc Res 64:148-161.
3. Brooks PC, Montgomery AM, Rosenfeld M, Reisfeld RA, Hu T, Klier G, et al. (1994). Integrin alphavbeta3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79:1157-1164.
4. Brummendorf T, Kenwrick S, Rathjen FG (1998). Neural cell recognition molecule L1: from cell biology to human hereditary brain malformations. Curr Opin Neurobiol 8:87-97.
5. Bussolati B, Deambrosis I, Russo S, Deregibus MC, Camussi G (2003). Altered angiogenesis and survival in human tumor-derived endothelial cells. FASEB J 17:1159-1161.
6. Carlos TM, Harlan JM (1994). Leukocyte-endothelial adhesion molecules. Blood 84:2068-2101.
7. Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, McEver RP, et al. (1998). Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 91:3527-3561.
8. Dietrich JB (2002). The adhesion molecule ICAM-1 and its regulation in relation with the blood-brain barrier. J Neuroimmunol 128:58-68.
9. Folkman J (2002). Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29:15-18.
10. Friedlander M, Theesfeld CL, Sugita M, Fruttiger M, Thomas MA, Chang S, et al. (1996). Involvement of integrins alphavbeta3 and alpha v beta 5 in ocular neovascular diseases. Proc Natl Acad Sci U S A 93:9764-9769.
11. Gasparini G, Brooks PC, Biganzoli E, Vermeulen PB, Bonoldi E, Dirix LY, et al. (1998). Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancer. Clin Cancer Res 4:2625-2634.
12. Griffioen AW, Damen CA, Martinotti S, Blijham GH, Groenewegen G (1996). Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors. Cancer Res 56:1111-1117.
13. Hall H, Djonov V, Ehrbar M, Hoechli M, Hubbell JA (2004). Heterophilic interactions between cell adhesion molecule L1 and alphavbeta3-integrin induce HUVEC process extension in vitro and angiogenesis in vivo. Angiogenesis 7:213-223.
14. Hidai C, Zupancic T, Penta K, Mikhail A, Kawana M, Quertermous EE, et al. (1998). Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. Genes Dev 12:21-33.
15. Hortsch M (1996). The L1 family of neural cell adhesion molecules: old proteins performing new tricks. Neuron 17:587-593.
16. Kowitz A, Kadmon G, Eckert M, Schirrmacher V, Schachner M, Altevogt P (1992). Expression and function of the neural cell adhesion molecule L1 in mouse leukocytes. Eur J Immunol 22:1199-1205.
17. Kroon ME, Koolwijk P, van der Vecht B, van Hinsbergh VW (2000). Urokinase receptor expression on human microvascular endothelial cells is increased by hypoxia: implications for capillary-like tube formation in a fibrin matrix. Blood 96:2775-2783.
18. Kujat R, Miragall F, Krause D, Dermietzel R, Wrobel KH (1995). Immunolocalization of the neural cell adhesion molecule L1 in nonproliferating epithelial cells of the male urogenital tract. Histochem Cell Biol 103:311-321.
19. Kumar CC (2003). Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis. Curr Drug Targets 4:123-131.
20. Kuphal S, Bauer R, Bosserhoff AK (2005). Integrin signaling in malignant melanoma. Cancer Metastasis Rev 24:195-222.
21. Linnemann D, Raz A, Bock E (1989). Differential expression of cell adhesion molecules in variants of K1735 melanoma cells differing in metastatic capacity. Int J Cancer 43:709-712.
22. Lou JN, Mili N, Decrind C, Donati Y, Kossodo S, Spiliopoulos A, et al. (1998). An improved method for isolation of microvascular endothelial cells from normal and inflamed human lung. In vitro Cell Dev Biol Anim 34:529-536.
23. McNeel DG, Eickhoff J, Lee FT, King DM, Alberti D, Thomas JP, et al. (2005). Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion. Clin Cancer Res 11:7851-7860.
24. Muller WA (1995). The role of PECAM-1 (CD31) in leukocyte emigration: studies in vitro and in vivo. J Leukoc Biol 57:523-528.
25. Penta K, Varner JA, Liaw L, Hidai C, Schatzman R, Quertermous T (1999). Del-1 induces integrin signaling and angiogenesis by ligation of alphavbeta3. J Biol Chem 274:11101-11109.
26. Reinmuth N, Liu W, Ahmad SA, Fan F, Stoeltzing O, Parikh AA, et al. (2003). Alphavbeta3 integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice. Cancer Res 63:2079-2087.
27. Ribeiro R, Lopes C, Medeiros R (2004). Leptin and prostate: implications for cancer prevention - overview of genetics and molecular interactions. Eur J Cancer Prev 13:359-368.
28. Ruegg C, Dormond O, Foletti A (2002). Suppression of tumor angiogenesis through the inhibition of integrin function and signaling in endothelial cells: which side to target? Endothelium 9:151-160.
29. Setty BN, Stuart MJ (1996). Vascular cell adhesion molecule-1 is involved in mediating hypoxia-induced sickle red blood cell adherence to endothelium: potential role in sickle cell disease. Blood 88:2311-2320.
30. Stromblad S, Becker JC, Yebra M, Brooks PC, Cheresh DA (1996). Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis. J Clin Invest 98:426-433.
31. Suzuma K, Takagi H, Otani A, Honda Y (1998). Hypoxia and vascular endothelial growth factor stimulate angiogenic integrin expression in bovine retinal microvascular endothelial cells. Invest Ophthalmol Vis Sci 39:1028-1035.
32. Thies A, Schachner M, Moll I, Berger J, Schulze HJ, Brunner G, et al. (2002). Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma. Eur J Cancer 38:1708-1716.
33. Voura EB, Ramjeesingh RA, Montgomery AM, Siu CH (2001). Involvement of integrin alpha(v)beta(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells. Mol Biol Cell 12:2699-2710.
34. Willam C, Schindler R, Frei U, Eckardt KU (1999). Increases in oxygen tension stimulate expression of ICAM-1 and VCAM-1 on human endothelial cells. Am J Physiol 276:H2044-H2052.
35. Yang H, Majno P, Morel P, Toso C, Triponez F, Oberholzer J, et al. (2002). Prostaglandin E(1) protects human liver sinusoidal endothelial cell from apoptosis induced by hypoxia reoxygenation. Microvasc Res 64:94-103.
36. Yip PM, Siu CH (2001). Cells utilize the homophilic binding site of L1 for cell-cell adhesion but L1-alphavbeta3 interaction for neurite outgrowth. J Neurochem 76:1552-1564.
37. Zund G, Uezono S, Stahl GL, Dzus AL, McGowan FX, Hickey PR, et al. (1997). Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes. Am J Physiol 273:C1571-C1580.