Spatially resolved measurement of dissolved oxygen in multistream microfluidic devices

IEEE Sensors Journal

Volumn 10, Issue 12, 2010, Pages 1813-1819

  Nock, Volker ^a   Blaikie, Richard J ^a  

^a UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

Hydrodynamic focusing; microfluidics; optical oxygen sensor; PtOEPK PS; spatial measurement

Indexed keywords

CELL BIOLOGY; CELLULAR DEVELOPMENT; COEFFICIENT OF DIFFUSION; DISSOLVED OXYGEN CONCENTRATIONS; HYDRODYNAMIC FOCUSING; IN-VITRO; MICRO-FLUIDIC DEVICES; MICROENVIRONMENTS; MICRON SCALE; MULTI-STREAM; ON CHIPS; OPTICAL OXYGEN SENSORS; PARALLEL FLOWS; PTOEPK/PS; SPATIAL MEASUREMENTS; SPATIALLY RESOLVED;

CYTOLOGY; DISSOLUTION; FLUID DYNAMICS; FOCUSING; HYDRODYNAMICS; LAMINAR FLOW; MICROCHANNELS; MICROFLUIDICS; OXYGEN SENSORS; PARALLEL FLOW; SENSORS; SPATIAL VARIABLES MEASUREMENT;

DISSOLVED OXYGEN;

EID: 77957739333     PISSN: 1530437X     EISSN: None     Source Type: Journal    
DOI: 10.1109/JSEN.2010.2049016     Document Type: Article

References (19)

1. S. Takayama, E. Ostuni, P. LeDuc, K. Naruse, D. E. Ingber, and G. M. Whitesides, "Laminar flows: Subcellular positioning of small molecules", Nature, vol. 411, pp. 1016-1016, 2001.
2. S. Takayama, E. Ostuni, P. LeDuc, K. Naruse, D. E. Ingber, and G. M. Whitesides, "Selective chemical treatment of cellular microdomains using multiple laminar streams", Chem. Biol., vol. 10, pp. 123-130, 2003.
3. H. Kaji, M. Nishizawa, and T. Matsue, "Localized chemical stimulation to micropatterned cells using multiple laminar fluid flows", Lab Chip, vol. 3, pp. 208-211, 2003.
4. B. Kuczenski, W. C. Ruder, W. C. Messner, and P. R. LeDuc, "Probing cellular dynamics with a chemical signal generator", in PLoS ONE, 2009, vol. 4, e4847.
5. S. Roy, S. Khanna, A. A. Bickerstaff, S. V. Subramanian, M. Atalay, M. Bierl, S. Pendyala, D. Levy, N. Sharma, M. Venojarvi, A. Strauch, C. G. Orosz, and C. K. Sen, "Oxygen sensing by primary cardiac fibroblasts: A key role of p21Waf1/Cip1/Sdi1", Circ. Res., vol. 92, pp. 264-271, 2003.
6. H. Zhang and G. Semenza, "The expanding universe of hypoxia", J. Mol. Med., vol. 86, pp. 739-746, 2008.
7. F. Wang, H. Wang, J. Wang, H.-Y. Wang, P. L. Rummel, S. V. Garimella, and C. Lu, "Microfluidic delivery of small molecules into mammalian cells based on hydrodynamic focusing", Biotechnol. Bioeng., vol. 100, pp. 150-158, 2008. (Pubitemid 351579025)
8. V. Nock, R. J. Blaikie, and T. David, "Patterning, integration and characterization of polymer optical oxygen sensors for microfluidic devices", Lab Chip, vol. 8, pp. 1300-1307, 2008.
9. D. B. Papkovsky, G. V. Ponomarev, W. Trettnak, and P. O'Leary, "Phosphorescent complexes of porphyrin ketones: Optical properties and application to oxygen sensing", Anal. Chem., vol. 67, pp. 4112-4117, 1995.
10. M. S. Munson, K. R. Hawkins, M. S. Hasenbank, and P. Yager, "Diffusion based analysis in a sheath flow microchannel: The sheath flow T-sensor", Lab Chip, vol. 5, pp. 856-862, 2005.
11. A. E. Kamholz, E. A. Schilling, and P. Yager, "Optical measurement of transverse molecular diffusion in a microchannel", Biophys. J., vol. 80, pp. 1967-1972, 2001.
12. D. C. Duffy, J. C. McDonald, O. J. A. Schueller, and G. M. Whitesides, "Rapid prototyping of microfluidic systems in Poly (dimethylsiloxane) ", Anal. Chem., vol. 70, pp. 4974-4984, 1998.
13. V. Nock, "Control and measurement of oxygen in microfluidic bioreactors", Ph. D. dissertation, Univ. Canterbury, Dep. Elect. Comp. Eng., Christchurch, New Zealand, 2009.
14. V. Nock, R. J. Blaikie, and T. David, "Generation and detection of laminar flow with laterally-varying oxygen concentration levels", in Proc. uTAS, San Diego, CA, 2008, pp. 299-301.
15. V. Nock and R. J. Blaikie, "Visualization and measurement of dissolved oxygen concentrations in hydrodynamic flow focusing", in Proc. 8th Ann. IEEE Conf. Sensors, Christchurch, New Zealand, 2009, pp. 1248-1251.
16. L.-L. Zhu, L.-Y. Wu, D. Yew, and M. Fan, "Effects of hypoxia on the proliferation and differentiation of NSCs", Mol. Neurobiol., vol. 31, pp. 231-242, 2005.
17. J. B. Knight, A. Vishwanath, J. P. Brody, and R. H. Austin, "Hydrodynamic focusing on a silicon chip: Mixing nanoliters in microseconds", Phys. Rev. Lett., vol. 80, p. 3863, 1998.
18. P. Han and D. M. Bartels, "Temperature dependence of oxygen diffusion in H2O and D2O", J. Phys. Chem., vol. 100, pp. 5597-5602, 1996.
19. V. Nock, R. J. Blaikie, and T. David, "Oxygen control for bioreactors and in vitro cell assays", AIP Proc., vol. 1151, pp. 67-70, 2009.