Dissolution modeling of bead formulations and predictions of bioequivalence for a highly soluble, highly permeable drug

Molecular Pharmaceutics

Volumn 7, Issue 5, 2010, Pages 1450-1457

  Sperry, David C ^a   Thomas, Steven J ^a   Lobo, Evelyn ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

absorption; bead formulation; bioequivalence; delayed release surface area; diffusion; Dissolution; enteric coating; model; particle size

Indexed keywords

HYDROCHLORIC ACID; HYDROXYPROPYLMETHYLCELLULOSE; SODIUM DIHYDROGEN PHOSPHATE; SUCROSE;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; BOUNDARY LAYER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIFFUSION COEFFICIENT; DOSE TIME EFFECT RELATION; DRUG FORMULATION; DRUG SOLUBILITY; ENTERIC COATED TABLET; HALF LIFE TIME; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATHEMATICAL MODEL; NORMAL HUMAN; PARTICLE SIZE; PREDICTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY ANALYSIS; SIMULATION; SOLID;

CHEMISTRY, PHARMACEUTICAL; HALF-LIFE; HUMANS; INTESTINAL ABSORPTION; MODELS, BIOLOGICAL; PERMEABILITY; PHARMACOKINETICS; SOLUBILITY; SURFACE PROPERTIES; TABLETS, ENTERIC-COATED; THERAPEUTIC EQUIVALENCY;

EID: 77957738362     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100118t     Document Type: Article

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