Effects of cAMP and β-adrenergic receptor antagonists on the function of peripheral T helper lymphocytes in patients with heart failure

NeuroImmunoModulation

Volumn 18, Issue 2, 2010, Pages 73-78

  Tian, Xiuqing ^a   Zhang, Lei ^a   Hou, Yinglong ^a   Xu, Wanju ^a   Dong, Yuling ^a   Liu, Jianhua ^a   Liang, Jiangjiu ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

cAMP; Carvedilol; Heart failure; Interferon ; Interleukin 10; Metoprolol; TH1; TH2

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; CYCLIC AMP; DIGITALIS GLYCOSIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GAMMA INTERFERON; INTERLEUKIN 10; METOPROLOL;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG EFFECT; FEMALE; FLOW CYTOMETRY; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RADIOIMMUNOASSAY; TH1 CELL; TH2 CELL;

ADRENERGIC BETA-ANTAGONISTS; ADULT; AGED; CARBAZOLES; CELL SEPARATION; CYCLIC AMP; FEMALE; FLOW CYTOMETRY; HEART FAILURE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; MALE; METOPROLOL; MIDDLE AGED; PROPANOLAMINES; RADIOIMMUNOASSAY; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 77957737169     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000319375     Document Type: Article

References (24)

1. Stewart S, Maclntyre K, Macleod MM: Trends in hospitalization for heart failure in Scotland 1990-1996 an epidemic that has reached its peak. Eur Heart 2001;22:209-217.
2. Brodde OE, Kretsch R, Ikezono K, Zerkowski HR, Reidemeister JC: Human β-adrenoceptors: relation of myocardial and lymphocyte beta-adrenoceptor density. Science 1986;231:1584-1585.
3. Gaqe JR, Fonarow G, Hamilton M: β-Blocker and angiotensin-converting enzyme inhibitor therapy is associated with decreased Th1/Th2 cytokine ratios and inflammatory cytokine production in patients with chronic heart failure. Neuroimmunomodulation 2004;11:173-180.
4. Tatli E, Kurum T, Aktoz M, Buyuklu M: Effects of carvedilol on right ventricular ejection fraction and cytokines levels in patients with systolic heart failure. Int J Cardiol 2008;125:273-276.
5. Ferrick DA, Schrenzel MD, Mulvania T: Differential production of interferon-γ and interleukin-4 in response to Th1-and Th2-stimulating pathogens by γδ T cells in vivo. Nature 1995;373:255-257.
6. Boyum A: Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 1968;21(suppl 97):77-89.
7. Vizi ES, Orso E, Osipenko ON: Neurochemical, electro-physiologic and immunocytochemical evidence for a noradrenergic link between the sympathetic nervous system and thymocytes. Neuroscience 1995;68:1263-1276.
8. Gagliardi MC, Sallusto F, Marinaro M: Effects of the adjuvant cholera toxin on dendritic cells: stimulatory and inhibitory signals that result in the amplification of immune responses. Int J Med Microbiol 2002;291:571-575.
9. Elenkov IJ, Wilder RL, Chrousos GP: The sympathetic nerve - an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 2000;52:595-638.
10. Liggett SB: Identification and characterization of a homogeneous population of β2-adrenergic receptors on human alveolar macrophages. Am Rev Respir Dis 1989;139:552-555.
11. Borger P, Hoekstra Y, Esselink MT, Postma DS, Zaagsma J, Vellenga E, Kauffman HF: β-Adrenoceptor-mediated inhibition of IFN-γ, IL-3, and GM-CSF mRNA accumulation in activated human T lymphocytes is solely mediated by the β2-adrenoceptor subtype. Am J Respir Cell Mol Biol 1998;19:400-407.
12. Kammer GM: The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response. Immunol Today 1988;9:222-229.
13. Montminy M: Transcriptional regulation by cyclic AMP. Annu Rev Biochem 1997;66:807-822.
14. Schillace RV, Andrews SF: The role of protein kinase A anchoring via the RII α regulatory subunit in the murine immune system. J Immunol 2005;174:6847-6853.
15. Iaccarino G, Barbato E, Cipolletta E: Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. Eur Heart J 2005;26:1752-1758.
16. Redwine LS, Mills PJ, Hong S: Cardiac-related hospitalization and/or death associated with immune dysregulation and symptoms of depression in heart failure patients. Psychosom Med 2007;69:23-29.
17. Yip HK, Youssef AA, Chang LT: Association of interleukin-10 level with increased 30-day mortality in patients with ST-segment elevation acute myocardial infarction undergoing primary coronary intervention. Circ J 2007;71:1086-1091.
18. Cheng X, Ding Y, Xia C: Atorvastatin modulates Th1/Th2 response in patients with chronic heart failure. J Card Fail 2009;15:551.
19. Yu Q, Watson RR: A role for T lymphocytes in mediating cardiac diastolic function. Am J Physiol Heart Circ Physiol 2005;289: H643-H651.
20. Reifenberg K, Lehr HA, Torzewski M: Interferon-7 induces chronic active myocarditis and cardiomyopathy in transgenic mice. Am J Pathol 2007;171:463-472.
21. Stumpf C, Lehner C, Yilmaz A: Decrease of serum levels of the antiinflammatory cytokine interleukin-10 in patients with advanced chronic heart failure. Clin Sci (Lond) 2003;105:45-50.
22. Li B, Liao YH, Huang YX: Effect of carvedilol on plasma cytokines network in patients with congestive heart failure. HK Coil Cardiol 2004;12(suppl 1): A57.
23. Metra M, Cas LD, di Lenarda A, Poole-Wilson P: β-Blockers in heart failure: are pharmacological differences clinically important? Heart Fail Rev 2004;9:123-130.
24. Most P, Eicher C, Völkers M, Pleger ST, Katus HA: Hope for a broken heart? Trends Biotechnol 2004;22:487-489.