Demonstration of disturbed activity of the lateral amygdaloid nucleus projection neurons in depressed patients by the AgNOR staining method

Journal of Affective Disorders

Volumn 126, Issue 3, 2010, Pages 402-410

  Gos, Tomasz ^a,b   Krell, Dieter ^b   Bielau, Hendrik ^b   Steiner, Johann ^b   Mawrin, Christian ^b   Trübner, Kurt ^c   Brisch, Ralf ^d   Bernstein, Hans Gert ^b   Jankowski, Zbigniew ^a   Bogerts, Bernhard ^b  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

AgNOR staining; Depression; Lateral amygdaloid nucleus; Postmortem

Indexed keywords

AMITRIPTYLINE; BIOLOGICAL MARKER; CHLORPROMAZINE; DIAZEPAM; LITHIUM; PARAFFIN; SILVER;

ADULT; AGED; AMYGDALOID NUCLEUS; ARTICLE; BIPOLAR DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSIS RELATED GROUP; DRUG EXPOSURE; FEMALE; HUMAN; HUMAN TISSUE; KARYOMETRY; LIFESPAN; LIMBIC CORTEX; MAJOR DEPRESSION; MALE; MENTAL PATIENT; MOOD DISORDER; NERVE CELL; NEUROIMAGING; PREFRONTAL CORTEX; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RIGHT HEMISPHERE; STAINING; SUICIDE;

ADULT; AGED; AMYGDALA; ANTIGENS, NUCLEAR; BIPOLAR DISORDER; DEPRESSIVE DISORDER, MAJOR; DOMINANCE, CEREBRAL; FEMALE; HUMANS; KARYOMETRY; MALE; MIDDLE AGED; NEURONS; REFERENCE VALUES; SUICIDE;

EID: 77957737143     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jad.2010.04.006     Document Type: Article

References (84)

1. H. Abe, P. Mehraein, and S. Weis A modified NOR-silver impregnation technique for amyloid plaques and neurofibrillary tangles: comparative assessment Neuropathol. Appl. Neurobiol. 20 1994 478 486
2. S.R. Alt, J.D. Turner, M.D. Klok, O.C. Meijer, E.A. Lakke, R.H. Derijk, and C.P. Muller Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed Psychoneuroendocrinology 35 2010 544 556
3. H. Barbas Specialized elements of orbitofrontal cortex in primates Ann. N. Y. Acad. Sci. 1121 2007 10 32
4. S. Berretta, H. Pantazopoulos, and N. Lange Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia Biol. Psychiatry 62 2007 884 893 (Pubitemid 47488225)
5. Y.B. Bezchlibnyk, X. Sun, J.F. Wang, G.M. MacQueen, B.S. McEwen, and L.T. Young Neuron somal size is decreased in the lateral amygdalar nucleus of subjects with bipolar disorder J. Psychiatry Neurosci. 32 2007 203 210
6. H. Bielau, C. Mawrin, D. Krell, M.W. Agelink, K. Trübner, R. Davis, T. Gos, B. Bogerts, H.G. Bernstein, and B. Baumann Differences in activation of the dorsal raphe nucleus depending on performance of suicide Brain Res. 1039 2005 43 52
7. H.P. Blumberg, E. Stern, S. Ricketts, D. Martinez, J. de Asis, T. White, J. Epstein, N. Isenberg, P.A. McBride, I. Kemperman, S. Emmerich, V. Dhawan, D. Eidelberg, J.H. Kocsis, and D.A. Silbersweig Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder Am. J. Psychiatry 156 1999 1986 1988
8. H.P. Blumberg, H.C. Leung, P. Skudlarski, C.M. Lacadie, C.A. Fredericks, B.C. Harris, D.S. Charney, J.C. Gore, J.H. Krystal, and B.S. Peterson A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices Arch. Gen. Psychiatry 60 2003 601 609
9. P. Bollini, S. Pampallona, G. Tibaldi, B. Kupelnick, and C. Munizza Effectiveness of antidepressants. Meta-analysis of dose-effect relationships in randomised clinical trials Br. J. Psychiatry 174 1999 297 303
10. M.P. Bowley, W.C. Drevets, D. Öngür, and J.L. Price Low glial numbers in the amygdala in major depressive disorder Biol. Psychiatry 52 2002 404 412
11. J. Burgdorf, and J. Panksepp The neurobiology of positive emotions Neurosci. Biobehav. Rev. 30 2006 173 187
12. U. Busto, E.M. Sellers, C.A. Naranjo, H. Cappell, M. Sanchez-Craig, and K. Sykora Withdrawal reaction after long-term therapeutic use of benzodiazepines N. Engl. J. Med. 315 1986 854 859
13. A. Büttner, S. Weis, G. Mall, C. Gall, and W. Eisenmenger The diagnostic relevance of cerebral amyloid angiopathy in the setting of forensic pathology - a report of two cases and review of the literature Leg. Med. (Tokyo) 3 2001 141 148
14. J.J. Carballo, C.P. Akamnonu, and M.A. Oquendo Neurobiology of suicidal behavior. An integration of biological and clinical findings Arch. Suicide Res. 12 2008 93 110
15. A.K. Cuellar, S.L. Johnson, and R. Winters Distinctions between bipolar and unipolar depression Clin. Psychol. Rev. 25 2005 307 339
16. H. de Wolde, J. Pruim, M.F. Mastik, J. Koudstaal, and W.M. Molenaar Proliferative activity in human brain tumors: comparison of histopathology and L-[1-(11)C]tyrosine PET J. Nucl. Med. 38 1997 1369 1374
17. M. Derenzini The AgNORs Micron 31 2000 117 120
18. W.C. Drevets Prefrontal cortical-amygdalar metabolism in major depression Ann. N.Y. Acad. Sci. 877 1999 614 637
19. W.C. Drevets Neuroimaging studies of mood disorders Biol. Psychiatry 48 2000 813 829
20. W.C. Drevets Orbitofrontal cortex function and structure in depression Ann. N. Y. Acad. Sci. 1121 2007 499 527
21. W.C. Drevets, J.L. Price, and M.L. Furey Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression Brain Struct. Funct. 213 2008 93 118
22. D. Figarella-Branger, D. Gambarelli, C. Dollo, B. Devictor, A.M. Perez-Castillo, L. Genitori, G. Lena, M. Choux, and J.F. Pellissier Infratentorial ependymomas of childhood. Correlation between histological features, immunohistological phenotype, silver nucleolar organizer region staining values and post-operative survival in 16 cases Acta Neuropathol. (Berl) 82 1991 208 216
23. N.S. Floyd, J.L. Price, A.T. Ferry, K.A. Keay, and R. Bandler Orbitomedial prefrontal cortical projections to distinct longitudinal columns of the periaqueductal gray in the rat J. Comp. Neurol. 422 2000 556 578
24. N.S. Floyd, J.L. Price, A.T. Ferry, K.A. Keay, and R. Bandler Orbitomedial prefrontal cortical projections to hypothalamus in the rat J. Comp. Neurol. 432 2001 307 328
25. L.J. Freedman, T.R. Insel, and Y. Smith Subcortical projections of area 25 (subgenual cortex) of the macaque monkey J. Comp. Neurol. 421 2000 172 188
26. L.M. Garcia-Moreno, N.M. Conejo, H.G. Pardo, M. Gomez, F.R. Martin, M.J. Alonso, and J.L. Arias Hippocampal AgNOR activity after chronic alcohol consumption and alcohol deprivation in rats Physiol. Behav. 72 2001 115 121
27. T. Gos, D. Krell, R. Brisch, H. Bielau, K. Trübner, H.G. Bernstein, and B. Bogerts The changes of AgNOR parameters of anterior cingulate pyramidal neurons are region-specific in suicidal and non-suicidal depressive patients World J. Biol. Psychiatry 8 2007 245 255
28. T. Gos, D. Krell, R. Brisch, H. Bielau, K. Trübner, J. Steiner, H.G. Bernstein, and B. Bogerts Demonstration of decreased activity of dorsal raphe nucleus neurons in depressed suicidal patients by the AgNOR staining method J. Affect. Disord. 112 2008 251 260
29. T. Gos, D. Krell, H. Bielau, J. Steiner, K. Trübner, R. Brisch, H.G. Bernstein, Z. Jankowski, and B. Bogerts Demonstration of disturbed activity of external globus pallidus projecting neurons in depressed patients by the AgNOR staining method J. Affect. Disord. 119 2009 149 155
30. T. Gos, D. Krell, H. Bielau, J. Steiner, C. Mawrin, K. Trübner, R. Brisch, H.G. Bernstein, Z. Jankowski, and B. Bogerts Demonstration of disturbed activity of orbitofrontal pyramidal neurons in depressed patients by the AgNOR staining method J. Affect. Disord. 118 2009 131 138
31. H.J.G. Gundersen, P. Bagger, T.F. Bendtsen, S.M. Evans, L. Korbo, N. Marcussen, A. Moller, K. Nielsen, J.R. Nyengaard, B. Pakkenberg, F.B. Sorensen, A. Vesterby, and M.J. West The new stereological tools, disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis AMPIS 96 1988 857 881
32. M. Hamidi, W.C. Drevets, and J.L. Price Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes Biol. Psychiatry 55 2004 563 569
33. A.R. Hariri, V.S. Mattay, A. Tessitore, F. Fera, and D.R. Weinberger Neocortical modulation of the amygdala response to fearful stimuli Biol. Psychiatry 53 2003 494 501
34. P.J. Harrison The neuropathology of primary mood disorder Brain 125 2002 1428 1449
35. M. Hayashida, T. Miyaoka, K. Tsuchie, H. Yasuda, R. Wake, A. Nishida, T. Inagaki, T. Toga, H. Nagami, T. Oda, and J. Horiguchi Hyperbilirubinemia-related behavioral and neuropathological changes in rats: a possible schizophrenia animal model Prog. Neuropsychopharmacol. Biol. Psychiatry 33 2009 581 588
36. C. Hercher, G. Turecki, and N. Mechawar Through the looking glass: examining neuroanatomical evidence for cellular alterations in major depression J. Psychiatr. Res. 43 2009 947 961
37. P.C. Holland, and M. Gallagher Amygdala-frontal interactions and reward expectancy Curr. Opin. Neurobiol. 14 2004 148 155
38. J. Janczukowicz The prognostic role of proliferation activity in human CNS tumours: the determination of AgNOR, PCNA and Ki-67 expression. Part 1: AgNOR expression in CNS tumours Folia Neuropathol. 41 2003 97 101
39. L.R. Johnson, M. Hou, A. Ponce-Alvarez, L.M. Gribelyuk, H.H. Alphs, L. Albert, B.L. Brown, J.E. LeDoux, and V. Doyère A recurrent network in the lateral amygdala: a mechanism for coincidence detection Front. Neural Circuits 2 2008 1 19
40. B.A. Jordan, B.D. Fernholz, L. Khatri, and E.B. Ziff Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons Nat. Neurosci. 10 2007 427 435
41. T.A. Klempan, C. Ernst, V. Deleva, B. Labonte, and G. Turecki Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder Biol. Psychiatry 66 2009 824 831
42. V. Krishnan, and E.J. Nestler The molecular neurobiology of depression Nature 455 2008 894 902
43. J. LeDoux The amygdala Curr. Biol. 17 2007 R868 R874
44. J. Levesque, F. Eugene, Y. Joanette, V. Paquette, B. Mensour, G. Beaudoin, J.M. Leroux, P. Bourgouin, and M. Beauregard Neural circuitry underlying voluntary suppression of sadness Biol. Psychiatry 53 2003 502 510
45. W. Lu, H. Tang, M. Fan, R. Mi, L. Wang, and J. Jia Research on nucleolar organizer regions of hippocampal neuron in Alzheimer's disease Chin. Med. J. 111 1998 282 284
46. J.K. Mai, and G. Paxinos Atlas of the Human Brain 1997 Academic Press San Diego
47. J.J. Mann Neurobiology of suicidal behaviour Nat. Rev. Neurosci. 4 2003 819 828
48. S. Maren, and G.J. Quirk Neuronal signalling of fear memory Nat. Rev. Neurosci. 5 2004 844 852
49. B.S. McEwen Mood disorders and allostatic load Biol. Psychiatry 54 2003 200 207
50. B.S. McEwen Glucocorticoids, depression, and mood disorders: structural remodeling in the brain Metabolism 54 2005 20 23
51. A.J. McGeorge, and R.L. Faul The organization of the projection from the cerebral cortex to the striatum in the rat Neuroscience 29 1989 503 537
52. H.D. Mennel, and I. Müller Morphometric investigation on nuclear and nucleolar arrangement and AgNOR content in the rat hippocampus under normal and ischemic conditions Exp. Toxicol. Pathol. 46 1994 491 501
53. J. Mitrofanis, and L. Mikuletic Organisation of the cortical projection to the zona incerta of the thalamus J. Comp. Neurol. 412 1999 173 185 (Pubitemid 29380333)
54. E.A. Murray The amygdala, reward and emotion Trends Cogn. Sci. 11 2007 489 497
55. E.J. Nestler, M. Barrot, R.J. DiLeone, A.J. Eisch, S.J. Gold, and L.M. Monteggia Neurobiology of depression Neuron 34 2002 13 25
56. A.C. Nugent, M.P. Milham, E.E. Bain, L. Mah, D.M. Cannon, S. Marrett, C.A. Zarate, D.S. Pine, J.L. Price, and W.C. Drevets Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry Neuroimage 30 2006 485 497
57. K.N. Ochsner, S.A. Bunge, J.J. Gross, and J.D. Gabrieli Rethinking feelings: an FMRI study of the cognitive regulation of emotion J. Cogn. Neurosci. 14 2002 1215 1229
58. D. Öngür, and J.L. Price The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans Cereb. Cortex 10 2000 206 219
59. C.A. Perico, C.R. Skaf, A. Yamada, F. Duran, C.A. Buchpiguel, C.C. Castro, J.C. Soares, and G.F. Busatto Relationship between regional cerebral blood flow and separate symptom clusters of major depression: a single photon emission computed tomography study using statistical parametric mapping Neurosci. Lett. 384 2005 265 270
60. P.J. Perry, and B. Alexander Sedative/hypnotic dependence: patient stabilization, tolerance testing, and withdrawal Drug Intell. Clin. Pharm. 20 1986 532 537
61. D. Ploton Structure and molecular organization of the nucleolus Zentralbl. Pathol. 140 1994 3 6
62. D. Ploton, M. Menager, P. Jeannesson, G. Himber, F. Pigeon, and J.J. Adnet Improvement in the staining and in the visualization of the argyrophilic proteins of the nucleolar organizer region at the optical level Histochem. J. 18 1986 5 14
63. D. Ploton, B. Visseaux-Coletto, J.C. Canellas, C. Bourzat, J.J. Adnet, C. Lechki, and N. Bonnet Semiautomatic quantification of silver-stained nucleolar organizer regions in tissue sections and cellular smears Anal. Quant. Cytol. Histol. 14 1992 14 23
64. M.O. Poulter, L. Du, I.C. Weaver, M. Palkovits, G. Faludi, Z. Merali, M. Szyf, and H. Anisman GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes Biol. Psychiatry 64 2008 645 652
65. J.L. Price Definition of the orbital cortex in relation to specific connections with limbic and visceral structures and other cortical regions Ann. N. Y. Acad. Sci. 1121 2007 54 71
66. A. Quiñones-Hinojosa, N. Sanai, J.S. Smith, and M.W. McDermott Techniques to assess the proliferative potential of brain tumors J. Neurooncol. 74 2005 19 30
67. A. Raine, J.R. Meloy, S. Bihrle, J. Stoddard, L. LaCasse, and M.S. Buchsbaum Reduced prefrontal and increased subcortical brain functioning assessed using positron emission tomography in predatory and affective murderers Behav. Sci. Law 16 1998 319 332
68. G. Rajkowska Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells Biol. Psychiatry 48 2000 766 777
69. I. Raska, P.J. Shaw, and D. Cmarko New insights into nucleolar architecture and activity Int. Rev. Cytol. 255 2006 177 235
70. M. Rebolledo Godoy, A.P. Rebolledo Godoy, and M. Oehmichen AgNORs during the process of wound healing. Time dependency as evaluated in vital and postmortem biopsy Int. J. Legal Med. 113 2000 244 246
71. E. Reusche Silver staining of senile plaques and neurofibrillary tangles in paraffin sections. A simple and effective method Pathol. Res. Pract. 187 1991 1045 1049
72. M.J. Rey, P. Schulz, C. Costa, P. Dick, and R. Tissot Guidelines for the dosage of neuroleptics. I: Chlorpromazine equivalents of orally administered neuroleptics Int. Clin. Psychopharmacol. 4 1989 95 104
73. E.T. Rolls The orbitofrontal cortex and reward Cereb. Cortex 10 2000 284 294
74. J. Rüschoff, H.P. Elsasser, and G. Adler Correlation of nucleolar organizer regions with secretory and regenerative process in experimental cerulein-induced pancreatitis in the rat Pancreas 11 1995 154 159
75. P. Sah, E.S. Faber, M. Lopez De Armentia, and J. Power The amygdaloid complex: anatomy and physiology Physiol. Rev. 83 2003 803 834
76. J. Savitz, and W.C. Drevets Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide Neurosci. Biobehav. Rev. 33 2009 699 771
77. L.J. Siever Neurobiology of aggression and violence Am. J. Psychiatry 165 2008 429 442
78. V. Sirri, S. Urcuqui-Inchima, P. Roussel, and D. Hernandez-Verdun Nucleolus: the fascinating nuclear body Histochem. Cell Biol. 129 2008 13 31
79. C.A. Stockmeier Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter J. Psychiatr. Res. 37 2003 357 373
80. A. Ströhle, and F. Holsboer Stress responsive neurohormones in depression and anxiety Pharmacopsychiatry 36 Suppl 3 2003 S207 S214
81. R.M. Sullivan, and A. Gratton Lateralized effects of medial prefrontal cortex lesions on neuroendocrine and autonomic stress responses in rats J. Neurosci. 19 1999 2834 2840
82. R.M. Sullivan, and A. Gratton Behavioral effects of excitotoxic lesions of ventral medial prefrontal cortex in the rat are hemisphere-dependent Brain Res. 927 2002 69 79
83. L.T. Young, Y.B. Bezchlibnyk, B. Chen, J.F. Wang, and G.M. MacQueen Amygdala cyclic adenosine monophosphate response element binding protein phosphorylation in patients with mood disorders: effects of diagnosis, suicide, and drug treatment Biol. Psychiatry 55 2004 570 577
84. D.S. Zahm, and M. Trimble The dopaminergic projection system, basal forebrain macrosystems, and conditioned stimuli CNS Spectr. 13 2008 32 40