Simultaneous release and ADME processes of poorly water-soluble drugs: Mathematical modeling

Molecular Pharmaceutics

Volumn 7, Issue 5, 2010, Pages 1488-1497

  Grassi, Gabriele ^a,b   Hasa, Dritan ^a   Voinovich, Dario ^a   Perissutti, Beatrice ^a   Dapas, Barbara ^a   Farra, Rossella ^b   Franceschinis, Erica ^c   Grassi, Mario ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

Mathematical modeling; oral administration; poorly soluble drugs

Indexed keywords

POVIDONE; VINPOCETINE;

ADULT; ARTICLE; CLINICAL ARTICLE; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; DRUG RELEASE; DRUG SOLUBILITY; GASTROINTESTINAL ABSORPTION; HUMAN; MALE; MATHEMATICAL MODEL; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; ADULT; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; HUMANS; INTESTINAL ABSORPTION; MALE; MATHEMATICAL CONCEPTS; MIDDLE AGED; MODELS, BIOLOGICAL; NANOPARTICLES; PHARMACOKINETICS; SOLUBILITY; VINCA ALKALOIDS; WATER;

EID: 77957735278     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp1001334     Document Type: Article

References (32)

1. Lee, P. I. Diffusion-Controlled Matrix Systems. In Treatise on Controlled Drug Delivery; Kydonieus, A., Ed.; Marcel Dekker Inc.: New York, Basel, Hong Kong, 1992; Chapter 3.
2. Peppas, N. A. Mathematical Models for Controlled Release Kinetics. In Medical Applications of Controlled Release: Applications and Evaluations; Langer, R. S., Wise, D. L., Eds.; CRC Press: Boca Raton, 1984; vol. II, pp 169 - 187.
3. Tapia, C.; Buckton, G.; Newton, J. M. Factors influencing the mechanism of release from sustained release matrix pellets, produced by extrusion/spheronisation Int. J. Pharm. 1993, 92, 211-218
4. Grassi, M.; Grassi, G.; Lapasin, R.; Colombo, I. Understanding drug release and adsorption mechansims: a phyisical and mathematical approach; CRC Press: Boca Raton, 2007.
5. Grassi, M.; Colombo, I.; Lapasin, R. Drug release from an ensemble of swellable crosslinked polymer particles J. Controlled Release 2000, 68, 97-113
6. Colombo, I.; Grassi, G.; Grassi, M. Drug Mechanochemical Activation J. Pharm. Sci. 2009, 98, 3961-3986
7. Debenedetti, P. G.; Tom, J. W.; Yeo, S. D. Application of supercritical fluids for the production of sustained delivery devices J. Controlled Release 1993, 24, 27-44
8. Di Muria, M.; Lamberti, G.; Titomanlio, G. Modeling the pharmacokinetics of extended release pharmaceutical systems Heat Mass Transfer 2009, 45, 579-589
9. Di Muria, M.; Lamberti, G.; Titomanlio, G. Physiologically Based Pharmacokinetics: A Simple, All Purpose Model Ind. Eng. Chem. Res. 2010, 49, 2969-2978
10. Siepmann, J.; Siepmann, F. Mathematical modeling of drug delivery Int. J. Pharm. 2009, 364, 207-212
11. Hasa, D. Attivazione meccanochimica di un composto contenente vinpocetina; Graduate thesis, University of Trieste, Department of Pharmaceutical Sciences, 2009.
12. Lorincz, C.; Szasz, K.; Kisfaludy, L. The synthesis of ethyl apovincaminate Arzneim. Forsch./Drug Res. 1976, 26, 1907-1908
13. Ribeiro, L. S. S.; Falcao, A. C.; Patricio, J. A. B.; Ferreira, D. C.; Veiga, F. J. B. Cyclodextrin multicomponent complexation and controlled release delivery strategies to optimize the oral bioavailability of vinpocetine J. Pharm. Sci. 2007, 96, 2018-2028
14. Szatmari, S. Z.; Whitehouse, P. J. Vinpocetine for cognitive impairment and dementia Cochrane Database Syst. Rev. 2003, 1, CD003119
15. Grandt, R.; Beitinger, R.; Schateltenbrand, R.; Braun, W. Vinpocetine pharmacokinetics in elderly subjects Arzneim. Forsch./Drug Res. 1989, 39, 1599-1602
16. Szakacs, T.; Veres, Z.; Vereczkey, L. In vitro-in vivo correlation of the pharmacokinetics of vinpocetine Pol. J. Pharmacol. 2001, 53, 623-628
17. Kata, M.; Lukacs, M. Enhancement of solubility of vinpocetine base with γ-cyclodextrin Pharmazie 1986, 41, 151-152
18. Vlase, L.; Bodiu, B.; Leucuta, S. E. Pharmacokinetics and comparative bioavailability of two vinpocetine tablet formulations in healthy volunteers by using the metabolite apovincaminic acid as Pharmacokinetic parameter Arzeim. Forsch./Drug Res. 2005, 55, 664-668
19. Quintavalle, U.; Voinovich, D.; Perissutti, B.; Serdoz, F.; Grassi, G.; Dal Col, A.; Grassi, M. Preparation of sustained release co-extrudates by hot-melt extrusion and mathematical modelling of in vitro/in vivo drug release profiles Eur. J. Pharm. Sci. 2008, 33, 282-293
20. Tenchov, B. G.; Yanev, T. K. Weibull distribution of particle sizes obtained by uniform random fragmentation J. Colloid Interface Sci. 1986, 111, 2-10
21. Camera-Roda, G.; Sarti, G. C. Mass transport with relaxation in polymers AIChE J. 1990, 36, 851-860
22. Patankar, S. V. Numerical Heat Transfer and Fluid Flow; Hemisphere Publishing: New York, 1986.
23. Nogami, H.; Nagai, T.; Youtsuyanagi, T. Dissolution phenomena of organic medicinals involving simultaneous phase changes Chem. Pharm. Bull. 1969, 17, 499-509
24. Peppas, N. A.; Reinhart, C. T. Solute Diffusion in Swollen Membranes. I. A New Theory J. Membr. Sci. 1983, 15, 275-287
25. Reinhart, C. T.; Peppas, N. A. Solute Diffusion in Swollen Membranes. II. Influence of Crosslinking on Diffusive Properties J. Membr. Sci. 1984, 18, 227-239
26. Grassi, M.; Lapasin, R.; Coviello, T.; Matricardi, P.; Di Meo, C.; Alhaique, F. Scleroglucan/borax/drug hydrogels: Structure characterisation by means of rheological and diffusion experiments Carbohydr. Polym. 2009, 78, 377-383
27. Brun, M.; Lallemand, A.; Quinson, J. F.; Eyraud, C. Changement d'etat liquide-solide dans les milieux poreux J. Chim. Phys. 1973, 70, 979-989
28. Zhang, M.; Efremov, M. Y.; Schiettekatte, F.; Olson, M. Y.; Kwan, A. T.; Lai, S. L.; Wisleder, T.; Greene, J. E.; Allen, L. H. Size-dependent melting point depression of nanostructures: nanocalorimetric measurements Phys. Rev. B 2000, 62, 10548-10557
29. Macheras, P.; Iliadis, A. Modeling in biopharmaceutics, pharmacokinetics and pharmacodynamics-homogeneous and heterogeneous approaches; Springer: New York, 2006; pp 113 - 117.
30. Berezhkovskiy, L. M. Determination of Mean Residence Time of Drug in Plasma and the Influence of the Initial Drug Elimination and Distribution on the Calculation of Pharmacokinetic Parameters J. Pharm. Sci. 2008, 98, 748-762
31. Ritschel, W. A. Handbook of Basic Pharmacokinetics; Drug Intelligence Publications: Hamilton, IL, 1980; 2nd ed. pp 413 - 426.
32. Amidon, G.; Lennernas, H.; Shah, V.; Crison, J. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability Pharm. Res. 1995, 12, 413-420