A multicenter, randomized, double-blind, parallel group pilot evaluation of the efficacy and safety of intravesical sodium chondroitin sulfate versus vehicle control in patients with interstitial cystitis/painful bladder syndrome

Urology

Volumn 76, Issue 4, 2010, Pages 804-809

  Nickel, J Curtis ^a   Egerdie, R Blair ^a   Steinhoff, Gary ^a   Palmer, Bruce ^a   Hanno, Philip ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROITIN SULFATE; UNCLASSIFIED DRUG; URACYST;

ADULT; ARTICLE; BREAST DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DYSURIA; FEMALE; FOLLOW UP; GASTROINTESTINAL DISEASE; HUMAN; INFECTION; INTERSTITIAL CYSTITIS; KIDNEY DISEASE; MACULAR RASH; MAJOR CLINICAL STUDY; MALE; MEDICAL INFORMATION; MULTICENTER STUDY; NAUSEA; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RASH; SKIN DISEASE; TREATMENT OUTCOME; URETHRAL PAIN; URETHRITIS; URINARY TRACT DISEASE;

ADMINISTRATION, INTRAVESICAL; ADULT; CHONDROITIN SULFATES; CYSTITIS, INTERSTITIAL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; PAIN; PILOT PROJECTS; PROSPECTIVE STUDIES; SAMPLE SIZE; TREATMENT OUTCOME;

EID: 77957730816     PISSN: 00904295     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/j.urology.2010.03.016     Document Type: Article

References (19)

1. J.C. Nickel Interstitial cystitis: A chronic pelvic pain syndrome Med Clin North Am 88 2004 467 482
2. C.L. Parsons Bladder surface glycosaminoglycans Efficient Mech Environ Adaptation. Urol 27 1986 9 14
3. R.E. Hurst Structure, function and pathology of proteoglycans and glycosaminoglycans in the urinary tract World J Urol 12 1994 3 10
4. A. Morales, L. Emerson, J.C. Nickel, and M. Lundie Intravesical hyaluronic acid in the treatment of refractory interstitial cystitis J Urol 156 1996 45 48
5. J. Emtage, A. Morales, J.P.W. Heaton, and R. Perez-Marrero Heparin in the treatment of interstitial cystitis J Urol 133 1985 168 [Abstract]
6. J.J. Bade, M. Laseur, L.T. Nieuwenburg, L.T. van der Weele, and H.J. Mensink A placebo-controlled study of intravesical Pentosanpolysulfate for the treatment of interstitial cystitis Br J Urol 79 1997 168 171
7. R.E. Hurst, J. Roy, and R.K. Min A deficit of chondroitin sulfate proteoglycans of the bladder uroepithelium in interstitial cystitis Urology 48 1996 817 821
8. R.B. Sorensen Chondroitin sulphate in the treatment of interstitial cystitis and chronic inflammatory disease of the urinary bladder Eur Urol Suppl 2 2003 16 18
9. G. Steinhoff The efficacy of chondroitin sulphate in treating interstitial cystitis Eur Urol Suppl 2 2003 14 16
10. J. Nordling, and A. van Ophoven Intravesical Glysosaminoglycan replenishment with chondroitin sulfate in chronic forms of cystitis Drug Res 58 2008 328 335
11. J.C. Nickel, B. Egerdie, J. Downey, R. Singh, A. Skehan, L. Carr, and K. Irvine-Bird A real-life multi-centre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulfate for the treatment of interstitial cystitis BJU Int 103 2008 56 60
12. P.M. Hanno, J.R. Landis, Y. Matthews-Cook, J. Kusek, and L. Nyberg Jr. Diagnosis of interstitial cystitis Revisited: lessons learned from the National Institutes of Health, interstitial cystitis database study J Urol 161 1999 553 557
13. M.P. O'Leary, G.R. Sant, F.J. Fowler, K.E. Whitmore, and J. Spolarich-Kroll The interstitial cystitis symptom index and problem index Urology 49 1997 58 63
14. R. Rosen, C. Brown, J. Heiman, S. Leiblum, C. Meston, and R. Shabsigh The female sexual function index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function J Sex Marital Ther 26 2000 191 208
15. J. Ware, M. Kosinski, and S.D. Keller A 12-1team short form health survey: construction of scales and preliminary tests of reliability and validity Med Care 34 1996 220 233
16. P.M. Hanno Re-imagining interstitial cystitis Urol Clin North Am 35 2008 91 99
17. R. Mayer, K.J. Propert, and K.M. Peters A randomized controlled trial of intravesical bacillus Calmette-Guerin for treatment refractory interstitial cystitis J Urol 173 2005 1186 1191
18. C.K. Payne, P.G. Mosbaugh, and J.B. Forrest Intravesical resiniferatoxin for the treatment of interstitial cystitis: a randomized, double-blind, placebo controlled trial J Urol 173 2005 1590 1594
19. J.C. Nickel, D. Shoskes, and K. Irvine-Bird Clinical phenotyping of women with interstitial cystitis/painful bladder syndrome (IC/PBS): A key to classification and potentially improved management J Urol 82 2009 155 160