A real-life multicentre clinical practice study to evaluate the efficacy and safety of intravesical chondroitin sulphate for the treatment of interstitial cystitis

BJU International

Volumn 103, Issue 1, 2009, Pages 56-60

  Nickel, J Curtis ^a   Egerdie, Blair ^b   Downey, Joe ^a   Singh, Rajiva ^c   Skehan, Anthony ^d   Carr, Leslie ^e   Irvine Bird, Karen ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b Urology Associates Urologic Medical Research   (Canada)

^c Sarnia General Hospital   (Canada)

^d Thunder Bay Regional Health Sciences Centre   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Chondroitin sulphate; Interstitial cystitis; Painful bladder syndrome

Indexed keywords

CHONDROITIN SULFATE; UNCLASSIFIED DRUG; URACYST;

ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; INTERSTITIAL CYSTITIS; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PRIORITY JOURNAL; SIDE EFFECT; URINARY FREQUENCY; URINARY TRACT INFECTION; URINARY URGENCY; URINE INCONTINENCE; VAGINITIS; VULVODYNIA;

ADMINISTRATION, INTRAVESICAL; ADULT; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS; CHONDROITIN SULFATES; COHORT STUDIES; CYSTITIS, INTERSTITIAL; FEMALE; GLYCOSAMINOGLYCANS; HUMANS; MIDDLE AGED; POTASSIUM; TREATMENT OUTCOME; YOUNG ADULT;

EID: 57649236108     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2008.08028.x     Document Type: Article

References (28)

1. Nickel JC. Interstitial cystitis: a chronic pelvic pain syndrome. Med Clin North Am 2004 88 : 467 81
2. Hanno PM. Re-imagining interstitial cystitis. Urol Clin North Am 2008 35 : 91 9
3. Parsons CL. Bladder surface glycosaminoglycan: efficient mechanism environmental adaptation. Urology 1986 27 (Suppl. 9 14
4. Hurst RE. Structure, function and pathology of proteoglycans and glycosaminoglycans in the urinary tract. World J Urol 1994 12 : 3 10
5. Mulholland SG, Hanno P, Parsons CL, Sant GR, Staskin DR. Pentosan polysulfate sodium for therapy of interstitial cystitis. A double-blind placebo-controlled clinical study. Urology 1990 35 : 552 8
6. Bade JJ, Laseur M, Nieuwenburg LT, van der Weele LT, Mensink HJ. A placebo-controlled study of intravesical pentosanpolysulfate for the treatment of interstitial cystitis. Br J Urol 1997 79 : 168 71
7. Emtage J, Morales A, Heaton JPW, Perez-Marrero R. Heparin in the treatment of interstitial cystitis. J Urol 1985 133 : 168A
8. Morales A, Emerson L, Nickel JC, Lundie M. Intravesical hyaluronic acid in the treatment of refractory interstitial cystitis. J Urol 1996 156 : 45 8
9. Hurst RE, Roy JB, Parsons CL. The role of glycosaminoglycans in normal bladder physiology and the pathophysiology of interstitial cystitis. In Grant GR, Interstitial Cystitis. Philadelphia : Lippincott-Raven, 1997 : 93 100
10. Hurst RE, Roy J, Min RK et al. A deficit of chondroitin sulfate proteoglycans of the bladder uroepithelium in interstitial cystitis. Urology 1996 48 : 817 21
11. Sorensen RB. Chondroitin sulphate in the treatment of interstitial cystitis and chronic inflammatory disease of the urinary bladder. Eur Urol Suppl 2003 2 : 16 8
12. Steinhoff G. The efficacy of chondroitin sulphate in treating interstitial cystitis. Eur Urol Suppl 2003 2 : 14 6
13. Hanno PM, Landis JR, Matthews-Cook Y, Kusek J, Nyberg L Jr. Diagnosis of interstitial cystitis revisited: lessons learned from the National Institutes of Health, Interstitial Cystitis Database Study. J Urol 1999 161 : 553 7
14. Parsons CL, Greenberger M, Gabal L, Bidair M, Barme G. The role of urinary potassium in the pathogenesis and diagnosis of interstitial cystitis. J Urol 1998 159 : 1862 7
15. O'Leary MP, Sant GR, Fowler FJ Jr., Whitmore KE, Spolarich-Kroll J. The interstitial cystitis symptom index and problem index. Urology 1997 49 (Suppl. 58 63
16. Mayer R, Propert KJ, Peters KM et al. A randomized controlled trial of intravesical bacillus Calmette-Guerin for treatment refractory interstitial cystitis. J Urol 2005 173 : 1186 91
17. Payne CK, Mosbaugh PG, Forrest JB et al. Intravesical resiniferatoxin for the treatment of interstitial cystitis: a randomized, double-blind, placebo controlled trial. J Urol 2005 173 : 1590 4
18. Karsenty G, Al Taweel W, Hajebrahimi S, Corcos J. Efficacy of interstitial cystitis treatments: a review. EAU-EBU Update Series 2006 4 : 47 61
19. Hwang P, Auclair B, Beechinor D, Diment M, Einarson TR. Efficacy of pentosan polysulfate in the treatment of interstitial cystitis: a meta-analysis. Urology 1997 50 : 39 43
20. Sant GR, Propert KJ, Hanno PM et al. A pilot clinical trial of oral pentosan polysulfate and oral hydroxyzine in patients with interstitial cystitis. J Urol 2003 170 : 810 5
21. Theoharides TC, Sant GR. Hydroxyzine therapy for interstitial cystitis. Urology 1997 49 (Suppl. 108 10
22. Van Ophoven A, Polupic S, Heinecke A, Hertle L. A prospective, randomized, placebo controlled, double-blind study of amitriptyline for the treatment of interstitial cystitis. J Urol 2004 172 : 533 6
23. ClinicalTrails.gov. Efficacy of Amitriptyline for Painful Bladder Syndrome (PBS). Available at: http://www.clinicaltrials.gov/ct2/show/ NCT00124306?cond=%22Cystitis%2C+Interstitial%22&rank=25. Accessed July 2008
24. Sant GR. Intravesical 50% dimethyl sulfoxide (Rimso-50) in treatment of interstitial cystitis. Urology 1987 29 (Suppl. 17 21
25. Perez-Marrero R, Emerson LE, Feltis JT. A control study of dimethyl sulfoxide in interstitial cystitis. J Urol 1988 140 : 36 9
26. Peters K, Diokno PK, Steinert B et al. The efficacy of intravesical tice strain bacillus Calmette-Guerin in the treatment of interstitial cystitis: a double-blind prospective placebo control trial. J Urol 1997 157 : 2090 4
27. Lazzeri M, Beneforti P, Spinelli M, Zanollo A, Baragli G, Turini D. Intravesical resiniferatoxin for the treatment of hypersensitive disorder: a randomized placebo controlled study. J Urol 2000 164 : 676 9
28. Hauser PJ, Doxmorov MG, Bane BL, Slobodov G, Culkin DJ, Hurst RE. Abnormal expression of differentiation related proteins and proteoglycans core proteins in the urothelium of patients with interstitial cystitis. J Urol 2008 179 : 764 9