Stacking multiple transgenes at a selected genomic site via repeated recombinase-mediated DNA cassette exchanges

Plant Physiology

Volumn 154, Issue 2, 2010, Pages 622-631

  Li, Zhongsen ^a   Moon, Bryan P ^a   Xing, Aiqiu ^a   Liu, Zhan Bin ^a   McCardell, Richard P ^a   Damude, Howard G ^a   Carl Falco, S ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORYNEBACTERIUM GLUTAMICUM; GLYCINE MAX; HORDEUM; HORDEUM VULGARE; YARROWIA LIPOLYTICA;

EID: 77957728140     PISSN: 00320889     EISSN: 15322548     Source Type: Journal    
DOI: 10.1104/pp.110.160093     Document Type: Article

References (33)

1. Cai CQ, Doyon Y, Ainley WM, Miller JC, DeKelver RC, Moehle EA, Rock JM, Lee YL, Garrison R, Schulenberg L, et al (2009) Targeted transgene integration in plant cells using designed zinc finger nucleases. Plant Mol Biol 69: 699-709
2. Cahoon EB, Shockey JM, Dietrich CR, Gidda SK, Mullen RT, Dyer JM (2007) Engineering oilseeds for sustainable production of industrial and nutritional feedstocks: solving bottlenecks in fatty acid flux. Curr Opin Plant Biol 10: 236-244
3. Chiba Y, Ishikawa M, Kijima F, Tyson RH, Kim J, Yamamoto A, Nambara E, Leustek T, Wallsgrove RM, Naito S (1999) Evidence for autoregulation of cystathionine g-synthase mRNA stability in Arabidopsis. Science 286: 1371-1374
4. Cohen S, Andreas Houben A, Segal D (2008) Extrachromosomal circular DNA derived from tandemly repeated genomic sequences in plants. Plant J 53: 1027-1034
5. Damude HG, Kinney AJ (2007) Engineering oilseed plants for a sustainable, land-based source of long chain polyunsaturated fatty acids. Lipids 42: 179-185
6. Damude HG, Kinney AJ (2008a) Enhancing plant seed oils for human nutrition. Plant Physiol 147: 962-968
7. Damude HG, Kinney AJ (2008b) Engineering oilseeds to produce nutritional fatty acids. Physiol Plant 132: 1-10
8. Falco SC, inventor. (July 4, 2006) Chimeric genes and methods for increasing the lysine and threonine content of the seeds of plants. US Patent Application No. 7071383
9. Falco SC, Guida AD, Locke MEH, inventors. (June 15, 1999) Nucleic acid fragments, chimeric genes and methods for increasing the methionine content of the seeds of plants. US Patent Application No. 591241
10. Galili G, Amir R, Hoefgen R, Hesse H (2005) Improving the levels of essential amino acids and sulfur metabolites in plants. Biol Chem 386: 817-831
11. Gao H, Smith J, Yang M, Jones S, Djukanovic V, Nicholson MG, West A, Bidney D, Falco SC, Jantz D, et al (2010) Heritable targeted mutagenesis in maize using a designed endonuclease. Plant J 61: 176-187
12. Hacham Y, Song L, Schuster G, Amir R (2007) Lysine enhances methionine content by modulating the expression of S-adenosylmethionine synthase. Plant J 51: 850-861
13. Heppard EP, Kinney AJ, Stecca KL, Miao GH (1996) Developmental and growth temperature regulation of two different microsomal v-6 desaturase genes in soybeans. Plant Physiol 110: 311-319
14. Hesse H, Kreft O, Maimann S, Zeh M, Willmitzer L, Höfgen R (2001) Approaches towards understanding methionine biosynthesis in higher plants. Amino Acids 20: 281-289
15. Hitz WD, inventor. (August 7, 2001) Nucleotide sequences of canola and soybean palmitoyl-ACP thioesterase genes and their use in the regulation of fatty acid content of the oils of soybean and canola plants. US Patent Application No. RE37317
16. Kinney AJ (2006) Metabolic engineering in plants for human health and nutrition. Curr Opin Biotechnol 17: 130-138
17. Kinney AJ, Cahoon EB, Damude HG, Hitz WD, Kolar CW, Liu ZB, inventors. (August 26, 2004) Production of very long chain polyunsaturated fatty acids in oilseed plants. US Patent Application No. WO2004071467
18. Li Z, Xing A, Moon BP, McCardell RP, Mills K, Falco SC (2009) Sitespecific integration of transgenes in soybean via recombinase-mediated DNA cassette exchange. Plant Physiol 151: 1087-1095
19. Lightner JE, Okuley JJ, Hitz WD, Kinney AJ, Yadav N, Perez Grau L, inventors. (September 12, 2006) Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants. US Patent Application No. 7105721
20. Louwerse JD, Van Lier MCM, Van der Steen DM, De Vlaam CMT, Hooykaas PJJ, Vergunst AC (2007) Stable recombinase-mediated cassette exchange in Arabidopsis using Agrobacterium tumefaciens. Plant Physiol 145: 1282-1293
21. Meyer K, Hitz WD, Yadav NS, Damude HG, inventors. (December 12, 2008) DGAT genes from Yarrowia lipolytica for increased seed storage lipid production and altered fatty acid profiles in soybean. US Patent Application No. WO2008147935
22. Nanto K, Yamada-Watanabet K, Ebinuma H (2005) Agrobacteriummediated RMCE approach for gene replacement. Plant Biotechnol J 3: 203-214
23. Ow DW (2002) Recombinase-directed plant transformation for the postgenome era. Plant Mol Biol 48: 183-200
24. Roesler K, Rao G (2000) A single disulfide bond restores thermodynamic and proteolytic stability to an extensively mutated protein. Protein Sci 9: 1642-1650
25. Shukla VK, Doyon Y, Miller JC, DeKelver RC, Moehle EA, Worden SE, Mitchell JC, Arnold NL, Gopalan S, Meng X, et al (2009) Precise genome modification in the crop species Zea mays using zinc-finger nucleases. Nature 459: 437-441
26. Sun SM, Liu Q (2004) Transgenic approaches to improve the nutritional quality of plant proteins. In Vitro Cell Dev Biol Plant 40: 155-162
27. Tao Y, Bidney D, Gordon-Kamm WJ, Lyznik LA, inventors. (January 25, 2007) Modified FRT recombination sites and methods of use. US Patent Application No. WO2007011733
28. Thu TT, Dewaele E, Trung LQ, Claeys M, Jacobs M, Angenon G (2007) Increasing lysine levels in pigeonpea (Cajanus cajan (L.) Millsp) seeds through genetic engineering. Plant Cell Tissue Organ Cult 91: 135-143
29. Townsend JA, Wright DA, Winfrey RJ, Fu F, Maeder ML, Joung JK, Voytas DF (2009) High-frequency modification of plant genes using engineered zinc-finger nucleases. Nature 459: 442-445
30. Wu G, Truksa M, Datla N, Vrinten P, Bauer J, Zank T, Cirpus P, Heinz E, Qiu X (2005) Stepwise engineering to produce high yields of very long-chain polyunsaturated fatty acids in plants. Nat Biotechnol 23: 1013-1017
31. Xing A, Moon BP, Mills KM, Falco SC, Li Z (2010) Revealing frequent alternative polyadenylation and widespread low level transcription read-through of novel plant transcription terminators. Plant Biotechnol J 8: 772-782
32. Zhu X, Galili G (2003) Increased lysine synthesis coupled with a knockout of its catabolism synergistically boosts lysine content and also transregulates the metabolism of other amino acids in Arabidopsis seeds. Plant Cell 15: 845-853
33. Zhu X, Galili G (2004) Lysine metabolism is concurrently regulated by synthesis and catabolism in both reproductive and vegetative tissues. Plant Physiol 135: 129-136