Histidine-rich glycoprotein promotes bacterial entrapment in clots and decreases mortality in a mouse model of sepsis

Blood

Volumn 116, Issue 13, 2010, Pages 2365-2372

  Shannon, Oonagh ^a   Rydengård, Victoria ^a   Schmidtchen, Artur ^a   Mörgelin, Matthias ^a   Alm, Per ^b   Sørensen, Ole E ^a   Björck, Lars ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; HISTIDINE RICH GLYCOPROTEIN; PLASMA PROTEIN; UNCLASSIFIED DRUG;

ABSCESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; BACTERICIDAL ACTIVITY; BLOOD CLOT; CONTROLLED STUDY; HOST RESISTANCE; HUMAN; INFECTION CONTROL; INFECTION SENSITIVITY; INTRACELLULAR KILLING; MORTALITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SEPSIS; STREPTOCOCCUS PYOGENES;

EID: 77957726744     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-02-271858     Document Type: Article

References (34)

1. Leung LL, Harpel PC, Nachman RL, Rabellino EM. Histidine-rich glycoprotein is present in human platelets and is released following thrombin stimulation. Blood. 1983;62(5):1016-1021.
2. Jones AL, Hulett MD, Parish CR. Histidine-rich glycoprotein: a novel adaptor protein in plasma that modulates the immune, vascular and coagulation systems. Immunol Cell Biol. 2005;83(2):106-118.
3. Juarez JC, Guan X, Shipulina NV, et al. Histidine-proline- rich glycoprotein has potent antiangiogenic activity mediated through the histidine-proline-rich domain. Cancer Res. 2002;62(18):5344-5350. (Pubitemid 35024611)
4. Chang NS, Leu RW, Rummage JA, Anderson JK, Mole JE. Regulation of macrophage Fc receptor expression and phagocytosis by histidine-rich glycoprotein. Immunology. 1992;77(4):532-538.
5. Chang NS, Leu RW, Rummage JA, Anderson JK, Mole JE. Regulation of complement functional efficiency by histidine-rich glycoprotein. Blood. 1992;79(11):2973-2980.
6. Rydengård V, Olsson AK, Mörgelin M, Schmidtchen A. Histidine-rich glycoprotein exerts antibacterial activity. FEBS J. 2007;274(2):377-389. (Pubitemid 46046648)
7. Borza DB, Morgan WT. Histidine-proline-rich glycoprotein as a plasma pH sensor: modulation of its interaction with glycosaminoglycans by pH and metals. J Biol Chem. 1998;273(10):5493-5499.
8. Tsuchida-Straeten N, Ensslen S, Schafer C, et al. Enhanced blood coagulation and fibrinolysis in mice lacking histidine-rich glycoprotein (HRG). J Thromb Haemost. 2005;3(5):865-872.
9. Rydengård V, Shannon O, Lundqvist K, et al. Histidine-rich glycoprotein protects from systemic Candida infection. PLoS Pathogens. 2008;4(8):e1000116.
10. Cunningham MW. Pathogenesis of group A streptococcal infections. Clin Microbiol Rev. 2000;13(3):470-511.
11. Tart AH, Walker MJ, Musser JM. New understanding of the group A Streptococcus pathogenesis cycle. Trends Microbiol. 2007;15(7):318-325.
12. Kwinn LA, Nizet V. How group A Streptococcus circumvents host phagocyte defenses. Future Microbiol. 2007;2(1):75.
13. Kantor FS. Fibrinogen precipitation by streptococcal M protein. J Exp Med. 1965;1:121:849-859.
14. Herwald H, Cramer H, Mörgelin M, et al. M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage. Cell. 2004;116(3):367-379. (Pubitemid 38366314)
15. Herwald H, Mörgelin M, Dahlback B, Björck L. Interactions between surface proteins of Streptococcus pyogenes and coagulation factors modulate clotting of human plasma. J Thromb Haemost. 2003;1(2):284-291.
16. Berge A, Sjöbring U. PAM, a novel plasminogen-binding protein from Streptococcus pyogenes. J Biol Chem. 1993;268(34):25417-25424.
17. Sanderson-Smith ML, Dinkla K, Cole JN, et al. M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate. FASEB J. 2008;22(8):2715-2722.
18. Shannon O, Hertzen E, Norrby-Teglund A, Mörgelin M, Sjöbring U, Björck L. Severe streptococcal infection is associated with M protein-induced platelet activation and thrombus formation. Mol Microbiol. 2007;65(5):1147-1157.
19. Åkesson P, Sjoholm AG, Björck L. Protein SIC, a novel extracellular protein of Streptococcus pyogenes interfering with complement function. J Biol Chem. 1996;271(2):1081-1088. (Pubitemid 26034969)
20. Roupé KM, Nybo M, Sjóbring U, Alberius P, Schmidtchen A, Sørensen OE. Injury is a major inducer of epidermal innate immune responses during wound healing. J Invest Dermatol. 2010;130(4):1167-1177.
21. Fernie-King BA, Seilly DJ, Davies A, Lachmann PJ. Streptococcal inhibitor of complement inhibits two additional components of the mucosal innate immune system: secretory leucocyte proteinase inhibitor and lysozyme. Infect Immun. 2002;70(9):4908-4916.
22. Frick IM, Åkesson P, Rasmussen M, Schmidtchen A, Bjórck L. SIC, a secreted protein of Streptococcus pyogenes that inactivates antibacterial peptides. J Biol Chem. 2003;278(19):16561-16566.
23. Levi M, Keller TT, van Gorp E, ten Cate H. Infection and inflammation and the coagulation system. Cardiovasc Res. 2003;60(1):26-39. (Pubitemid 38373473)
24. Leung LL. Interaction of histidine-rich glycoprotein with fibrinogen and fibrin. J Clin Invest. 1986;77(4):1305-1311.
25. Schneider LA, Korber A, Grabbe S, Dissemond J. Influence of pH on wound-healing: a new perspective for wound-therapy? Arch Dermatol Res. 2007;298(9):413-420.
26. Raju R, Weiner M, Enquist IF. Quantitation of local acidosis and hypoxia produced by infection. Am J Surg. 1976;132(1):64-66.
27. Gorodetsky R, Mou X, Blankenfeld A, Marx G. Platelet multielemental composition, lability, and subcellular localization. Am J Hematol. 1993;42(3):278-283. (Pubitemid 23079881)
28. Ashbaugh CD, Warren HB, Carey VJ, Wessels MR. Molecular analysis of the role of the group A streptococcal cysteine protease, hyaluronic acid capsule, and M protein in a murine model of human invasive soft-tissue infection. J Clin Invest. 1998;102(3):550-560.
29. Goldmann O, Chhatwal GS, Medina E. Contribution of natural killer cells to the pathogenesis of septic shock induced by Streptococcus pyogenes in mice. J Infect Dis. 2005;191(8):1280-1286.
30. Norrby-Teglund A, Pauksens K, Norgren M, Holm SE. Correlation between serum TNF alpha and IL-6 levels and severity of group A streptococcal infections. Scand J Infect Dis. 1995;27(2):125-130.
31. Norrby-Teglund A, Chatellier S, Low DE, McGeer A, Green K, Kotb M. Host variation in cytokine responses to superantigens determine the severity of invasive group A streptococcal infection. Eur J Immunol. 2000;30(11):3247-3255.
32. Sun H, Ringdahl U, Homeister JW, et al. Plasminogen is a critical host pathogenicity factor for group A streptococcal infection. Science. 2004;305(5688):1283-1286. (Pubitemid 39129231)
33. Sun H, Wang X, Degen JL, Ginsburg D. Reduced thrombin generation increases host susceptibility to group A streptococcal infection. Blood. 2009;113(6):1358-1364.
34. Cole JN, McArthur JD, McKay FC, et al. Trigger for group A streptococcal M1T1 invasive disease. FASEB J. 2006;20(10):1745-1747.