Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men

Psychosomatic Medicine

Volumn 72, Issue 7, 2010, Pages 601-607

  Williams, Redford B ^a   Surwit, Richard S ^a   Siegler, Ilene C ^a   Ashley Koch, Allison E ^a   Collins, Ann L ^a   Helms, Michael J ^a   Georgiades, Anastasia ^a   Boyle, Stephen H ^a   Brummett, Beverly H ^a   Barefoot, John C ^a   Grichnik, Katherine ^a   Stafford Smith, Mark ^a   Kuhn, Cynthia M ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

cardiovascular risk factors; central nervous system; hostility; MAOA uVNTR polymorphism; metabolic syndrome components; serotonin

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; SEROTONIN; AMINE OXIDASE (FLAVIN CONTAINING);

ADULT; ARTICLE; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; GENE FREQUENCY; GENOTYPE; HOSTILITY; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; PRIORITY JOURNAL; PSYCHOSOCIAL DISORDER; ALLELE; CLUSTER ANALYSIS; CORONARY DISEASE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; METABOLIC SYNDROME X; METABOLISM; PROMOTER REGION; RISK FACTOR;

ADULT; ALLELES; CENTRAL NERVOUS SYSTEM; CLUSTER ANALYSIS; CORONARY DISEASE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOSTILITY; HUMANS; HYDROXYINDOLEACETIC ACID; MALE; METABOLIC SYNDROME X; MONOAMINE OXIDASE; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RISK FACTORS; SEROTONIN;

EID: 77957700120     PISSN: 00333174     EISSN: 15347796     Source Type: Journal    
DOI: 10.1097/PSY.0b013e3181eb9d67     Document Type: Article

References (51)

1. Williams RB, Haney TL, Lee KL, Blumenthal JA, Kong Y. Type A behavior, hostility, and coronary atherosclerosis, Psychosom Med 1980; 42:539-49.
2. Barefoot JC, Dahlstrom WG, Williams RB. Hostility, CHD incidence, and total mortality: a 25-year follow-up study of 255 physicians. Psychosom Med 1983;45:59-63.
3. Shekelle RB, Gale M, Ostfeld AM, Paul O. Hostility, risk of coronary disease, and mortality. Psychosom Med 1983;45:219-28.
4. Dembroski T, MacDougall J, Costa P, Grandits G. Components of hostility as predictors of sudden death and myocardial infarction in the Multiple Risk Factor Intervention Trial. Psychsom Med 1989;51:514-22.
5. Chida Y, Steptoe A. The association of anger and hostility with future coronary heart disease: a meta-analytic review of prospective evidence. J Am Col Cardiology 2009;53:936-46.
6. Boyle SH, Williams RB, Mark DB, Brummett BH, Siegler IC, Barefoot JC. Hostility, age, and mortality in a sample of cardiac patients. Am J Cardiol 2005;96:64-6.
7. Boyle SH, Williams RB, Mark DB, Brummett BH, Siegler IC, Helms MJ, Barefoot JC. Hostility as a predictor of survival in patients with coronary artery disease. Psychosom Med 2004;66:629-32.
8. Williams RB, Barefoot JC, Blumenthal JA, Helms MJ, Luecken L, Pieper CF, Siegler IC, Suarez EC. Psychosocial correlates of job strain in a sample of working women. Arch Gen Psychiatry 1997;54:543-8.
9. Barefoot JC, Peterson BL, Dahlstrom WG, Siegler IC, Anderson NB, Williams RB Jr. Hostility patterns and health implications: correlates of Cook-Medley Hostility scale scores in a national survey. Health Psychol 1991;10:18-24.
10. Matthews KA, Kelsey SF, Meilahn EN, Kuller LH, Wing RR. Educational attainment and behavioral and biologic risk factors for coronary heart disease in middle-aged women. Am J Epidemiol 1989;129: 1132-44.
11. Kaplan GA. Where do shared pathways lead? Some reflections on a research agenda. Psychosom Med 1995;57:208-12.
12. Scherwitz KW, Perkins LL, Chesney MA, Hughes GH, Sidney S, Mano-lio TA. Hostility and health behaviors in young adults: the CARDIA study. Coronary Artery Risk Development in Young Adults Study. Am J Epidemiol 1992;136:136-45.
13. Siegler IC, Peterson BL, Barefoot JC, Williams RB. Hostility during late adolescence predicts coronary risk factors at midlife. Am J Epidemiol 1992;136:146-54.
14. Suarez EC, Kuhn CM, Schanberg SM, Williams RB Jr, Zimmermann EA. Neuroendocrine, cardiovascular, and emotional responses of hostile men: the role of interpersonal challenge. Psychosom Med 1998;60:78-88.
15. Markovitz JH. Hostility is associated with increased platelet activation in coronary heart disease. Psychosom Med 1998;60:586-91.
16. Musselman DL, Miller AH, Porter MR, Manatunga A, Gao F, Penna S, Pearce BD, Landry J, Glover S, McDaniel JS, Nemeroff CB. Higher than normal plasma interleukin-6 concentrations in cancer patients with depression. Am J Psychiatry 2001;158:1252-7.
17. Rothermundt M, Arolt V, Peters M, Gutbrodt H, Fenker J, Kersting A, Kirchner H. Inflammatory markers in major depression and melancholia. J Affect Disorders 2001;63:93-102.
18. Surwit RS, Williams RB, Siegler IC, Lane JD, Helms M, Applegate KL, Zucker N, Feinglos MN, McCaskill CM, Barefoot JC. Hostility, race, and glucose metabolism in nondiabetic individuals. Diabetes Care 2002;25:835-9.
19. Niaura R, Banks SM, Ward KD, Stoney CM, Spiro A 3rd, Aldwin CM, Landsberg L, Weiss ST. Hostility and the metabolic syndrome in older males: the normative aging study. Psychosom Med 2000;62:7-16.
20. Leboyer M, Bellivier F, Nosten-Bertrand M, Jouvent R, Pauls D, Mallet J. Psychiatric genetics: search for phenotypes. Trends Neurosci 1998;21:102-5.
21. Lucki I. The spectrum of behaviors influenced by serotonin. Biol Psychiatry 1998;44:151-62.
22. Ramage AG. Central cardiovasclar regulation and 5-hydroxytryptamine receptors. Brain Res Bull 2001;56:425-39.
23. Horacek J, Kuzmiakova M, Hoschi C, Andel M, Bahbonh R. The relationship between central serotonergic activity and insulin sensitivity in healthy volunteers. Psychoneuroendocrinology 1999;24:785-97.
24. Williams RB. Neurobiology, cellular and molecular biology, and psychosomatic medicine. Psychosom Med 1994;56:308-15.
25. Williams RB. Lower socioeconomic status and increased mortality. Early childhood roots and the potential for successful interventions. JAMA 1998;279:1745-6.
26. Muldoon MR, Sved AF, Flory JD, Perel JM, Matthews KA, Manuck SB. Inverse relationship between fenfluramine-induced prolactin release and blood pressure in humans. Hypertension 1998;32:972-5.
27. Muldoon MF, Mackey RH, Williams KV, Korytkowski MT, Flory JD, Manuck SB. Low centeral nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivity. J Clin Endocrinol Metab 2004;89:266-71.
28. Stanley M, Traskman-Benz L, Dorovini-Zis K. Correlations between aminergic metabolites simultaneously obtained from human CSF and brain. Life Sci 1985;37:1279-86.
29. Doudet D, Hommer D, Higley JD, Andreason PJ, Moneman R, Suomi SJ, Linnoila M. Cerebral glucose metabolism, CSF 5-HIAA levels, and aggressive behavior in rhesus monkeys. Am J Psychiatry 1995;152:1782-7.
30. Higley JD, Linnoila M. Low central nervous system serotonergic activity is traitlike and correlates with impulsive behavior. A nonhuman primate model investigating genetic and environmental influences on neurotrans-mission. Ann N Y Acad Sci 1997;29:39-56.
31. Roy A, Adinoff B, Linnoila M. Acting out hostility in normal volunteers. Negative correlation with levels of 5-HIAA in cerebrospinal fluid. Psychiatry Res 1988;24:187-94.
32. Ballenger J, Goodwin FK, Major LF, Brown GL. Alcohol and central serotonin metabolism in man. Arch Gen Psychiatry 1979;36:224-7.
33. Williams RB, Marchuk DA, Gadde KM, Barefoot JC, Grichnik K, Helms MJ, Kuhn CM, Lewis JG, Schanberg SM, Stafford-Smith M, Suarez EC, Clary GL, Svenson IK, Siegler IC. Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychop-harmacology 2003;28:533-41.
34. Valley CM, Willard HF. Genomic and epigenomic approaches to the study of X chromosome inactivation. Curr Opin Genet Dev 2006;16:240-5.
35. Burroughs AR, Visscher WA, Haney T, Efland JR, Barefoot JC, Williams RB, Siegler IC. Community recruitment process by race, gender and SES gradient: lessons learned from the Community Health and Stress Evaluation (CHASE) study experience. J Community Health 2003;28:421-37.
36. Nordin C, Lindstrom L, Wieselgren IM. Acid monoamine metabolites in the CSF of healthy controls punctured without preceding strict bedrest: a retrospective study. J Psychiatr Res 1996;30:127-33.
37. Rimmler J, McDowell G. Development of a data coordinating center (DCC): data quality control for complex disease studies. Am J Hum Genet 1998;63:240-6.
38. Sabol SZ, Hu S, Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet 1998;103:273-9.
39. Doudet D, Hommer D, Higley JD, Andreason PJ, Moneman R, Suomi SJ, Linnoila M. Cerebral glucose metabolism, CSF 5-HIAA levels, and aggressive behavior in rhesus monkeys. Am J Psychiatry 1995;152:1782-7.
40. Barefoot JC, Dodge KA, Peterson BL, Dahlstrom WG, Williams RB. The Cook-Medley hostility scale: item content and ability to predict survival. Psychosom Med 1989;51:46-57.
41. Buss AH, Perry M. The aggression questionnaire. J Pers Soc Psychol 1992;63:452-9.
42. Roy A, Adinoff B, Linnoila M. Acting out hostility in normal voluteers: negative correlation with levels of 5HIAA in cerebrospinal fluid. Psychiatry Res 1988;24:187-94.
43. Weiner D. Subtle and obvious keys for the MMPI. J Consult Clin Psychol 1948;12:164-70.
44. Beck AT, Ward CB, Mendelson M, Mock J, Erbaugh J. An inventory for Measuring Depression. Arch Gen Psychiatry 1961;4:53-61.
45. Anda R, Williamson D, Jones D, Macera C, Eaker E, Glassman A, Marks J. Depressed affect, hopelessness, and the risk of ischemic heart disease in a cohort of U.S. adults. Epidemiology 1993;4:285-94.
46. Costa PT, McCrae RR. NEO-PI-R Professional Manual. Odessa, FL: Psychological Assessment Resources; 1992.
47. Berkman L, Breslow L, Wingard D. Health practices and mortality risk. In: Berkman L, Breslow L, editors. Health and Ways of Living. The Alameda County Study. New York: Oxford University Press; 1983.
48. Cohen S, Hoberman HM. Positive events and social support as buffers of life change stress. J Appl Soc Psychol 1983;13:99-125.
49. Schier MF, Carver CS. Optimism, coping and health: assessment and implications of generalized outcome expectancies. Health Psychol 1985; 4:219-47.
50. Cohen J. Statistical Power Analysis for the Behavoral Sciences. New York: Academic Press; 1969.
51. Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ. A genomic-systems biology map for cardiovascular function. Science 2001;294:1723-6.